Publications marquantes (équipe)

Defective autophagy in CD4 T cells drives liver fibrosis via type 3 inflammation
Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity
jeudi 20 février 2025

Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells
mercredi 19 février 2025

PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability
mercredi 19 février 2025

Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome
mercredi 19 février 2025

Macrophage Implication in IPF: Updates on Immune, Epigenetic, and Metabolic Pathways
mercredi 19 février 2025

CXCL6 in idiopathic pulmonary fibrosis: a novel mediator in the complex epithelial-mesenchymal crosstalk
mercredi 19 février 2025

Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function
mercredi 19 février 2025

Updates on the controversial roles of regulatory lymphoid cells in idiopathic pulmonary fibrosis
vendredi 10 janvier 2025

Augmentation des cas de scorbut chez les enfants en France depuis la pandémie de Covid
mercredi 23 octobre 2024

Les amibes sont nos amies.
jeudi 12 septembre 2024

Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation
mardi 9 juillet 2024

L’association du bulevirtide à l’interféron-pegylé comme traitement de durée définie pour l’hépatite chronique Delta
mercredi 15 mai 2024

WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease
mercredi 15 mai 2024

Erythrocytosis associated with IgA nephropathy
mercredi 15 mai 2024

Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1
mercredi 15 mai 2024

Chronic Myelomonocytic Leukemia Patients With Lysozyme Nephropathy and Renal Infiltration Display Markers of Severe Disease
mercredi 15 mai 2024

Monoclonal gammopathy of unknown significance in kidney transplanted patients: novel insights into long-term outcomes
mercredi 15 mai 2024

Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study
mercredi 15 mai 2024

Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management
mardi 7 mai 2024

Les basophiles, par leur expression de PD-L1 et de l’IL-4, promeuvent l’accumulation pathogénique des cellules T auxiliaires folliculaires dans le lupus.
mardi 2 avril 2024

Rôle direct de la flore intestinale dans l’auto-immunité mis en évidence par les médecins
dimanche 10 décembre 2023

Imaging flow cytometry of tumoroids: A new method for studying GPCR expression
dimanche 10 décembre 2023

Pathological overview of steatohepatitic hepatocellular carcinoma in a surgical series
dimanche 10 décembre 2023

Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations
dimanche 10 décembre 2023

Editorial: A year in review: discussions in molecular and structural endocrinology
dimanche 10 décembre 2023

A new NRF2 activator for the treatment of human metabolic dysfunction-associated fatty liver disease
dimanche 10 décembre 2023

Pathogenesis of primary liver carcinomas
samedi 9 décembre 2023

The Orexin receptors: Structural and anti-tumoral properties
samedi 9 décembre 2023

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease
vendredi 9 décembre 2023

Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis
jeudi 23 novembre 2023

Acute-on-Chronic Liver Failure
jeudi 23 novembre 2023

Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration
jeudi 23 novembre 2023

Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)
mercredi 8 novembre 2023

Pathogenic accumulation of T follicular helper cells in lupus disease depends on PD-L1 and IL-4 expressing basophils
mercredi 8 novembre 2023

Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases
mercredi 25 octobre 2023

M1-aminopeptidase family – beyond antigen-trimming activities
lundi 16 octobre 2023

Role of adherent and invasive Escherichia coli in Crohn’s disease: lessons from the postoperative recurrence model
lundi 16 octobre 2023

Increased Incidence of Pediatric Uveitis Associated with the COVID-19 Pandemic Occurring Before COVID-19 Vaccine Implementation: A Time-Series Analysis
lundi 16 octobre 2023

Calculating the fraction of Kawasaki disease potentially attributable to seasonal pathogens: a time series analysis
lundi 16 octobre 2023

Extracellular vesicles as biomarkers in liver diseases: A clinician’s point of view
vendredi 13 octobre 2023

Le TNFα bloque la voie anti-inflammatoire de l’interleukine-10 par l’intermédiaire de l’axe NOX2-Lyn-SHP-1 dans les monocytes humains.
vendredi 22 septembre 2023

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries
vendredi 22 septembre 2023

The Changing Demographics of Hepatitis B Virus Infection
vendredi 22 septembre 2023

Hepatitis D virus: Improving virological knowledge to develop new treatments
vendredi 22 septembre 2023

Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection
vendredi 22 septembre 2023

miRNAs as Potential Biomarkers for Viral Hepatitis B and C
vendredi 22 septembre 2023

Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease
vendredi 22 septembre 2023

Early virological response in six patients with hepatitis D virus infection and compensated cirrhosis treated with Bulevirtide in real-life
vendredi 22 septembre 2023

New therapies for hepatitis delta virus infection
vendredi 22 septembre 2023

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection
vendredi 22 septembre 2023

Hepatitis-B virus: replication cycle, targets, and antiviral approaches
vendredi 22 septembre 2023

Hepatitis D Virus Infection
jeudi 14 septembre 2023

Activating FcγR function depends on endosomal-signaling platforms
mercredi 13 septembre 2023

Food additive emulsifiers and risk of cardiovascular disease in the NutriNet-Santé cohort: prospective cohort study
mercredi 2 août 2023

Acinar-to-Ductal Metaplasia (ADM): On the Road to Pancreatic Intraepithelial Neoplasia (PanIN) and Pancreatic Cancer
jeudi 13 juillet 2023

Efficiency of Orexin-A for Inflammatory Flare and Mucosal Healing in Experimental Colitis: Comparison with the Anti-TNF Alpha Infliximab
vendredi 30 juin 2023

Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis
jeudi 29 juin 2023

The Effect of Sex-Specific Differences on IL-10−/− Mouse Colitis Phenotype and Microbiota
jeudi 15 juin 2023

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis
jeudi 15 juin 2023

Cell metabolism-based therapy for liver fibrosis, repair and hepatocellular carcinoma
jeudi 11 mai 2023

MALDI Imaging, a Powerful Multiplex Approach to Decipher Intratumoral Heterogeneity: Combined Hepato-Cholangiocarcinomas as Proof of Concept
vendredi 7 avril 2023

MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
jeudi 9 mars 2023

Basophils contribute to pristane-induced Lupus-like nephritis model
jeudi 9 mars 2023

Basophil involvement in lupus nephritis: a basis for innovation in daily care
jeudi 9 mars 2023

IgE in the Pathogenesis of SLE: From Pathogenic Role to Therapeutic Target
jeudi 9 mars 2023

Effects of BAFF Neutralization on Atherosclerosis Associated With Systemic Lupus Erythematosus
jeudi 9 mars 2023

The high affinity IgE receptor: a signaling update
jeudi 9 mars 2023

Basophils and IgE contribute to mixed connective tissue disease development
jeudi 9 mars 2023

SARS-CoV-2 infection among inpatients with systemic lupus erythematosus in France: a nationwide epidemiological study
jeudi 9 mars 2023

Autoimmunity, IgE and FcεRI-bearing cells
jeudi 9 mars 2023

AMG853, A Bispecific Prostaglandin D2 Receptor 1 and 2 Antagonist, Dampens Basophil Activation and Related Lupus-Like Nephritis Activity in Lyn-Deficient Mice
jeudi 9 mars 2023

CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development
jeudi 9 mars 2023

Systemic lupus erythematosus flare following SARS-CoV2 infection: the implication of IFNα and anti-IFNα autoantibodies
jeudi 9 mars 2023

Weaning of maintenance immunosuppressive therapy in lupus nephritis (WIN-Lupus): results of a multicentre randomised controlled trial
jeudi 9 mars 2023

Rab44 regulates murine mast cell-driven anaphylaxis through kinesin-1-dependent secretory granule translocation
jeudi 9 mars 2023

Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation
jeudi 9 mars 2023

Basophils and IgE in autoimmunity: Mechanisms and therapeutic targets
jeudi 9 mars 2023

Impact of BNT162b2 mRNA anti-SARS-CoV-2 vaccine on interferon-alpha production by plasmacytoid dendritic cells and autoreactive T cells in patients with systemic lupus erythematosus: The COVALUS project
jeudi 2 mars 2023

Analysis of the Efficacy and the Long-term Metabolic and Nutritional Status of Sleeve Gastrectomy with Transit Bipartition Compared to Roux-en-Y Gastric Bypass in Obese Rats
jeudi 2 mars 2023

Shortening the Biliopancreatic Limb Length of One Anastomosis Gastric Bypass Maintains Glucose Homeostasis Improvement with Limited Weight Loss
jeudi 26 janvier 2023

Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice
jeudi 26 janvier 2023

Molecular deciphering of primary liver neuroendocrine neoplasms confirms their distinct existence with foregut-like profile
jeudi 26 janvier 2023

Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
jeudi 26 janvier 2023

Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression
jeudi 26 janvier 2023

Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs
jeudi 26 janvier 2023

Gene expression signature as a surrogate marker of microvascular invasion on routine hepatocellular carcinoma biopsies
jeudi 26 janvier 2023

Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions
jeudi 26 janvier 2023

Transarterial chemoembolisation enhances programmed death-1 and programmed death-ligand 1 expression in hepatocellular carcinoma
jeudi 26 janvier 2023

Long-term outcomes following resection of hepatocellular adenomas with small foci of malignant transformation or malignant adenomas
jeudi 26 janvier 2023

Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma
jeudi 26 janvier 2023

New insights into the pathophysiology and clinical care of rare primary liver cancers
jeudi 26 janvier 2023

A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis
jeudi 26 janvier 2023

Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma
jeudi 26 janvier 2023

Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset
jeudi 26 janvier 2023

The role of endocytic trafficking in antigen T cell receptor activation
jeudi 26 janvier 2023

Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches
jeudi 26 janvier 2023

IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses
jeudi 26 janvier 2023

The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells
jeudi 19 janvier 2023

Impaired respiratory burst contributes to infections in PKCδ-deficient patients
jeudi 19 janvier 2023

Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis
jeudi 19 janvier 2023

Apocynin prevents GM-CSF-induced-ERK1/2 activation and -neutrophil survival independently of its inhibitory effect on the phagocyte NADPH oxidase NOX2
jeudi 19 janvier 2023

CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival
jeudi 19 janvier 2023

Metformin Inhibits ROS Production by Human M2 Macrophages via the Activation of AMPK
lundi 16 janvier 2023

ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes
mercredi 11 janvier 2023

Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF
mercredi 11 janvier 2023

Targeting cell-intrinsic metabolism for antifibrotic therapy
lundi 28 novembre 2022

The Appendix Orchestrates T-Cell Mediated Immunosurveillance in Colitis-Associated Cancer
mercredi 10 août 2022

PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides
mercredi 10 août 2022

A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma
mercredi 10 août 2022

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer
mercredi 16 mars 2022

Tumor Solid Stress: Assessment with MR Elastography under Compression of Patient-Derived Hepatocellular Carcinomas and Cholangiocarcinomas Xenografted in Mice
mercredi 16 mars 2022

Comparison of pulsed and oscillating gradient diffusion-weighted MRI for characterizing hepatocellular nodules in liver cirrhosis: ex vivo study in a rat model
mercredi 16 mars 2022

Quantification of hepatic steatosis with ultrasound: promising role of attenuation imaging coefficient in a biopsy-proven cohort
lundi 14 février 2022

Prevention and treatment of nutritional complications after bariatric surgery
lundi 14 février 2022

Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study.
jeudi 10 février 2022

Impaired p47phox phosphorylation in neutrophils from p67phox-deficient chronic granulomatous disease patients
lundi 24 janvier 2022

Protein Kinase CK2 acts as a molecular brake to control NADPH oxidase 1 activation and colon inflammation
jeudi 13 janvier 2022

CD62L on blood basophils: a first pre-treatment predictor of remission in severe lupus nephritis
vendredi 16 juillet 2021

Pancreatic Ductal Adenocarcinoma Arising in Young and Old Patients Displays Similar Molecular Features
lundi 31 mai 2021

Inherited glycosylphosphatidylinositol defects cause the rare Emm-negative blood phenotype and developmental disorders
jeudi 6 mai 2021

Tumour and stroma RNA signatures predict more accurately distant recurrence than clinicopathological factors in resected pancreatic adenocarcinoma
lundi 15 février 2021

Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass
lundi 15 février 2021

Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells
vendredi 29 janvier 2021

Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment
mardi 19 janvier 2021

Mast Cell Chymase and Kidney Disease
jeudi 22 octobre 2020

Dietary Emulsifiers Directly Impact AdherentInvasive E. coli Gene Expression to Drive Chronic Intestinal Inflammation
jeudi 8 octobre 2020

COVID-19: découverte, diagnostic et développement de médicaments
vendredi 18 septembre 2020

LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling.
vendredi 18 septembre 2020

The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils
jeudi 20 août 2020

Hepatitis B surface antigen seroclearance: Immune mechanisms, clinical impact, importance for drug development
jeudi 20 août 2020

Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 or 6 infection (ENDURANCE-5,6): an open-label, multicentre, phase 3b trial
jeudi 20 août 2020

Targets and future direct-acting antiviral approaches to achieve hepatitis B virus cure
jeudi 20 août 2020

Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases
jeudi 20 août 2020

Towards HBV curative therapies
jeudi 20 août 2020

Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure?
jeudi 20 août 2020

Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis
mercredi 19 août 2020

Eliminating hepatitis C within low-income countries – The need to cure genotypes 4, 5, 6
mercredi 19 août 2020

MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C
mardi 28 juillet 2020

Short Bowel Syndrome: A Paradigm for Intestinal Adaptation to Nutrition?
vendredi 24 juillet 2020

Nod2 Protects the Gut From Experimental Colitis Spreading to Small Intestine
mercredi 24 juin 2020

Immune-checkpoint inhibitor anti-PD1 aggravates colitis-associated colorectal cancer without enhancing intestinal inflammation
mardi 16 juin 2020

Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model
mardi 4 février 2020

Gastric bypass specifically impairs liver parameters as compared with sleeve gastrectomy, independently of evolution of metabolic disorders.
mardi 4 février 2020

Intestinal plasticity in response to nutrition and gastrointestinal surgery.
mardi 4 février 2020

Effect of different bariatric surgeries on dietary protein bioavailability in rats
lundi 3 février 2020

Combining imaging and tumour biopsy improves the diagnosis of combined hepatocellular-cholangiocarcinoma
lundi 3 février 2020

The dual role of ROS-generating NADPH oxidases in gastrointestinal inflammation and therapeutic perspectives.

Les dernières publications marquantes

Date de publication : 06 octobre 2025 En savoir +

Blockade of mTOR ameliorates IgA nephropathy by correcting CD89 and CD71 dysfunctions in humanized mice

PLoS One.

Auteurs : Cambier Alexandra Da silva Jennifer Bex-Coudrat Julie Canesi Fanny Lison Lachize Neanne Aurélie Sannier Hélène Mathieu Boedec Erwan Amandine Badie Monteiro Renato
Date de publication : 03 octobre 2025 En savoir +

Silybum marianum seeds mitigate pro-inflammatory functions of human neutrophils and alleviate ulcerative colitis in rats

Inflammopharmacology.

Auteurs : Kouki Ahmed Riadh Marrouchi Abdelaziz Souli Salwa Bouabdallah Ferjani Wafa Dang Pham My-Chan Amadou Dicko El Benna Jamel Mossadok Ben-Attia
Date de publication : 28 septembre 2025 En savoir +

Predictive value of metabolic state on PanNET response to mTOR inhibitors

Endocr Relat Cancer

Auteurs : Cros Jérome Margot Bucau Matthieu Tihy Maxime Palazzo Pierre Bourgoin Anais Chassac Albuquerque Miguel Sauvanet Alain Dokmak Safi Dioguardi Burgio Marco Paradis Valérie Olivia Hentic Ruszniewski Philippe De Mestier Louis Rebours Vinciane Couvelard Anne

Contacts utiles

Accès rapide

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