Presentation

The scientific focus area “Pathophysiology of Inflammatory & Fibrotic Diseases” aims to decipher the underlying inflammatory and fibrotic mechanisms of chronic diseases affecting various organs, including the lungs, liver, kidneys, and intestines. Inflammation and fibrosis are major physiological and/or pathological responses involved in numerous chronic diseases. A deep understanding of these processes is therefore essential to identify new therapeutic targets.

Our research focuses on identifying common features of inflammatory mechanisms within immune, endothelial, epithelial, and fibroblastic cells, highlighting the cellular and molecular interactions that contribute to disease progression. By exploring these processes in diverse contexts such as viral hepatitis, inflammatory and fibrotic lung diseases, gastrointestinal disorders, and cancers, we aim to develop innovative approaches to modulate inflammation and limit fibrosis.

This research axis benefits from the multidisciplinary expertise of all our research teams, each bringing a complementary perspective to the study of these diseases. Our researchers combine fundamental, translational, and clinical approaches to gain a better understanding of the mechanisms involved and advance scientific knowledge. Our goal is to propose therapeutic strategies tailored to the specificities of each organ and improve the management of patients suffering from these chronic diseases.