Leader
-
Rautou Pierre-Emmanuel
- 01 40 87 52 83
- pierre-emmanuel.rautou@inserm.fr
Our team is working on the role of vessels in liver disease. We are interested in rare vascular liver diseases (Budd-Chiari syndrome, extrahepatic vein thrombosis and porto-sinusoidal vascular diseases), nonalcoholic steatohepatitis and cirrhosis.
Recent advances indicate that intestinal and visceral adipose tissues play a key role in liver diseases. This suggests that substances are released by these tissues, influencing liver function. Liver endothelial cells are among the first cells to encounter blood from intestinal and visceral fat tissues. They are an active interface between blood and other hepatic cells. However, the role of liver endothelial cells in liver diseases is paradoxically very poorly understood. Our team has therefore set itself the objective of highlighting the involvement of liver endothelial cells in non-alcoholic steatohepatitis and cirrhosis.
Extracellular vesicles are membrane-bound vesicles released by cells into the extracellular space. They include apoptotic bodies, microvesicles, also previously known as microparticles, and exosomes. Extracellular vesicles are able to transmit information from one cell to another. We are currently determining the role of extracellular vesicles in progression and complications of liver diseases. To do so, we analyze their roles in intercellular communication between the liver and other organs, as well as among the liver itself. Extracellular vesicles can also be used as biomarkers. We have already demonstrated that hepatocyte microvesicles can predict the course of patients with cirrhosis. We are now validating these results in large cohorts of patients. To finish, we are developing new detection strategies of extracellular vesicles of other origins to predict more accuratly the evolution of liver diseases.
Previously called non-cirrhotic portal hypertension or nodular regenerative hyperplasia, is a rare disease characterized by alterations in the portal veins and/or sinusoids leading in some patients to portal hypertension and its complications. We are studying the pathophysiology of this disease as well as the future of patients with this disease.
Publication date : 01 March 2020 More
Autors : Hammoutene Adel Biquard Louise Juliette Lasselin Marouane Kheloufi Tanguy Marion Anne-Clémence Vion Jules Mérian Nathalie Colnot Xavier Loyer Alain Tedgui Patrice Codogno Lotersztajn Sophie Paradis Valérie Chantal M Boulanger Rautou Pierre-Emmanuel
Publication date : 01 June 2019 More
Autors : Hammoutene Adel Rautou Pierre-Emmanuel
Publication date : 01 October 2018 More
Autors : Payancé A Silva-Junior G Bissonnette J Tanguy Marion Pasquet B Levi C Roux O Nekachtali O Baiges A Hernández-Gea V Laouénan C Lebrec D ALBUQUERQUE Miguel Paradis Valérie Moreau Richard Valla Dominique Durand François Boulanger CM Garcia-Pagan JC Rautou Pierre-Emmanuel
Publication date : 01 August 2017 More
Autors : Bissonnette J Altamirano J Devue C Roux O Payancé A Lebrec D Bedossa Pierre Valla Dominique Durand François Ait-Oufella H Sancho-Bru P Caballeria J Ginès P Boulanger CM Bataller R Rautou Pierre-Emmanuel
Publication date : 04 January 2017 More
Autors : Poisson Johanne Lemoinne S Boulanger C Durand François Moreau Richard Valla Dominique Rautou Pierre-Emmanuel
Publication date : 15 January 2016 More
Autors : Rautou Pierre-Emmanuel Tatsumi K Antoniak S Owens AP Sparkenbaugh E Holle LA Wolberg AS Kopec AK Pawlinski R Luyendyk JP Mackman N Poisson Johanne Lemoinne S Boulanger C Durand François Moreau Richard Valla Dominique Rautou Pierre-Emmanuel
Publication date : 14 June 2014 More
Autors : Lemoinne S Thabut D Housset C Moreau Richard Valla Dominique Boulanger CM Rautou Pierre-Emmanuel
Publication date : 30 March 2012 More
Autors : Rautou Pierre-Emmanuel Bresson J Sainte-Marie Y Vion AC Paradis Valérie Renard JM Devue C Heymes C Letteron Philippe Elkrief Laure Lebrec D Valla Dominique Tedgui A Moreau Richard Boulanger CM