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Team Rautou 2021

Vessels in liver diseases (Atip-Avenir)

Team Rautou

Department Hepato-Gastroenterology Department

 

Leader

 

Line-up

 

Presentation

Our team is working on the role of vessels in liver disease. We are interested in rare vascular liver diseases (Budd-Chiari syndrome, extrahepatic vein thrombosis and porto-sinusoidal vascular diseases), nonalcoholic steatohepatitis and cirrhosis.

Current research directions :

  • Liver sinusoidal endothelial cells in the progression of liver diseases
  • Extracellular vesicles in liver diseases
  • Porto-sinusoidal vascular disease

  • Liver sinusoidal endothelial cells in the progression of liver diseases

Recent advances indicate that intestinal and visceral adipose tissues play a key role in liver diseases. This suggests that substances are released by these tissues, influencing liver function. Liver endothelial cells are among the first cells to encounter blood from intestinal and visceral fat tissues. They are an active interface between blood and other hepatic cells. However, the role of liver endothelial cells in liver diseases is paradoxically very poorly understood. Our team has therefore set itself the objective of highlighting the involvement of liver endothelial cells in non-alcoholic steatohepatitis and cirrhosis.

  • Extracellular vesicles in liver diseases

Extracellular vesicles are membrane-bound vesicles released by cells into the extracellular space. They include apoptotic bodies, microvesicles, also previously known as microparticles, and exosomes. Extracellular vesicles are able to transmit information from one cell to another. We are currently determining the role of extracellular vesicles in progression and complications of liver diseases. To do so, we analyze their roles in intercellular communication between the liver and other organs, as well as among the liver itself. Extracellular vesicles can also be used as biomarkers. We have already demonstrated that hepatocyte microvesicles can predict the course of patients with cirrhosis. We are now validating these results in large cohorts of patients. To finish, we are developing new detection strategies of extracellular vesicles of other origins to predict more accuratly the evolution of liver diseases.

  • Porto-sinusoidal vascular disease

Previously called non-cirrhotic portal hypertension or nodular regenerative hyperplasia, is a rare disease characterized by alterations in the portal veins and/or sinusoids leading in some patients to portal hypertension and its complications. We are studying the pathophysiology of this disease as well as the future of patients with this disease.

 

Landmark publications

  • Publication date : 01 March 2020 More

    A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis
    J Hepatol.

    Autors : Hammoutene Adel Biquard Louise Juliette Lasselin Marouane Kheloufi Tanguy Marion Anne-Clémence Vion Jules Mérian Nathalie Colnot Xavier Loyer Alain Tedgui Patrice Codogno Lotersztajn Sophie Paradis Valérie Chantal M Boulanger Rautou Pierre-Emmanuel

  • Publication date : 01 June 2019 More

    Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease.
    J Hepatol.

    Autors : Hammoutene Adel Rautou Pierre-Emmanuel

  • Publication date : 01 October 2018 More

    Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis.
    Hepatology

    Autors : Payancé A Silva-Junior G Bissonnette J Tanguy Marion Pasquet B Levi C Roux O Nekachtali O Baiges A Hernández-Gea V Laouénan C Lebrec D ALBUQUERQUE Miguel Paradis Valérie Moreau Richard Valla Dominique Durand François Boulanger CM Garcia-Pagan JC Rautou Pierre-Emmanuel

  • Publication date : 01 August 2017 More

    A prospective study of the utility of plasma biomarkers to diagnose alcoholic hepatitis.
    Hepatology.

    Autors : Bissonnette J Altamirano J Devue C Roux O Payancé A Lebrec D Bedossa Pierre Valla Dominique Durand François Ait-Oufella H Sancho-Bru P Caballeria J Ginès P Boulanger CM Bataller R Rautou Pierre-Emmanuel

  • Publication date : 04 January 2017 More

    Liver sinusoidal endothelial cells: physiology and role in liver diseases
    J Hepatol.

    Autors : Poisson Johanne Lemoinne S Boulanger C Durand François Moreau Richard Valla Dominique Rautou Pierre-Emmanuel

  • Publication date : 15 January 2016 More

    Hepatocyte Tissue Factor Contributes to the Hypercoagulable State in a Mouse Model of Chronic Liver Injury.
    J Hepatol.

    Autors : Rautou Pierre-Emmanuel Tatsumi K Antoniak S Owens AP Sparkenbaugh E Holle LA Wolberg AS Kopec AK Pawlinski R Luyendyk JP Mackman N Poisson Johanne Lemoinne S Boulanger C Durand François Moreau Richard Valla Dominique Rautou Pierre-Emmanuel

  • Publication date : 14 June 2014 More

    The emerging roles of microvesicles in liver diseases.
    Nat Rev Gastro Hepat

    Autors : Lemoinne S Thabut D Housset C Moreau Richard Valla Dominique Boulanger CM Rautou Pierre-Emmanuel

  • Publication date : 30 March 2012 More

    Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis.
    Gastroenterology.

    Autors : Rautou Pierre-Emmanuel Bresson J Sainte-Marie Y Vion AC Paradis Valérie Renard JM Devue C Heymes C Letteron Philippe Elkrief Laure Lebrec D Valla Dominique Tedgui A Moreau Richard Boulanger CM

 
 

Site de référence pour les Appels à Projets


Les dernières publications marquantes

  • Publication date : 17 January 2023 More

    ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes
    PNAS

    Autors : Asma Tlili Pintard Coralie Hurtado-Nedelec Maria Margarita Liu Dan Viviana Marzaioli Thieblemont Nathalie Dang Pham My-Chan El Benna Jamel

  • Publication date : 30 November 2022 More

    Comparative Analysis of a Locally Resampling MR Elastography Reconstruction Algorithm in Liver Fibrosis
    JMRI

    Autors : Page Gwenael JULEA Felicia Paradis Valérie Vilgrain Valérie Valla Dominique Van Beers Bernard Garteiser Philippe

  • Publication date : 03 November 2022 More

    JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm
    Nature Communications.

    Autors : Rida Al-Rifai Marie Vandestienne Jean-Rémi Lavillegrand Tristan Mirault Julie Cornebise Poisson Johanne Ludivine Laurans Bruno Esposito Chloé James Olivier Mansier Pierre Hirsch Fabrizia Favale Rayan Braik Camille Knosp Jose Vilar Giuseppe Rizzo Alma Zernecke Antoine-Emmanuel Saliba Alain Tedgui Maxime Lacroix Lionel Arrive Ziad Mallat Soraya Taleb Marc Diedisheim Clément Cochain Rautou Pierre-Emmanuel Hafid Ait-Oufella