The Inflammation Research Center brings together about 250 researchers, lecturer-researchers, hospital-university staff, technical agents (ITA), doctoral students, post-docs and trainees with the objective of establishing in France a Center of Excellence which links the basic research with translational and clinical research in inflammatory diseases.
The IRC hosts 12 teams labeled INSERM, University of Paris and CNRS and works closely with the APHP to ensure an application approach to research.
The IRC is a major player in the laboratory of excellence “Institute of Inflammatory Diseases” (Inflamex) coordinated by R. Monteiro, DHU Unity (led by D.Valla) and DHU Fire (co-coordinated by B. Crestani, G Steg & E. Daugas)
The Center provides researchers and engineers from around the world with 5 scientific platforms and 10 technical platforms, and also offers services in the field of proteomics, recombinant protein constitution, electron microscopy, biochemistry and immunoassay. imaging of the small animal.
The activity of the center is conducted mainly on the campus of the Bichat Hospital, within the Paris Diderot University. The sites of Beaujon and Robert Debré complete all the premises of the IRC, which now has more than 4,000 m2.
The objectives of the IRC are:
- to understand fundamentally the basics of inflammatory processes and development fibrosis
- to identify new pathophysiological mechanisms of inflammatory diseases
- identify biomarkers associated with diseases and develop new imaging tools
- to create new preclinical animal models allowing proof of concept (POC) for the study of inflammatory diseases
- the search for new therapeutic approaches.
The IRC is organized into two scientific departments:
- Department of Hepato-Gastroenterology (HGE)
- Department of Nephro-Immuno-Hematology (NIH)
The IRC Instances
Council of the Center
The Center Council discusses and rules on all aspects of the overall scientific strategy, organization and modalities of the inner life of the Center.
It examines any proposal to welcome new teams and any major internal restructuring of the teams.
It includes the director, the assistant director, the secretary general, and the manager (s) of each research team. All the staff is represented by elected representatives of the different categories:
- Representatives elected as Researchers and Researcher-Professors: Marc Benhamou, Anne Dumay (Alternate: Isabelle Chantret)
- Representatives elected from the ITA / BIATSS: Valérie Gratio, Pascal Nicole and Sandrine Olivré
(substitutes: Jennifer Da Silva, Marion Tanguy and Pascale Toprieux)
- Representative elected Student & Post-doc: Manon Allaire
- Permanent guests: platform managers and H & S engineer
Led by Richard Moreau, the IRC’s Ethics and Scientific Integrity Committee is a body that responds to the French and European prerogatives concerning the integrity of scientific results.
Its role is to ensure the veracity of the results obtained and to alert the Management Committee of the Center (CODIR) in the case of suspicion by a third party of the lack of veracity of the results. Integrity refers to the integrity referents designated by the authorities (INSERM, CNRS, APHP, Academics).
Led by Marc Benhamou, the doctoral student support committee accompanies and listens to young IRC researchers during their thesis period.
The Inflammation Research Center (IRC) decides to establish a Committee of Ethics and Scientific Integrity (CEIS), an advisory body whose mission is to answer any question of ethics and scientific integrity. raised in the center and brought to his attention. It aims in particular to prevent any aggravation of a conflict situation on these plans and to resolve them as soon as possible.
Rules of procedure of the CEIS:
- Art 1: The CEIS is made up of five members of the IRC volunteered and whose appointment is validated in council of Center. It includes at least one ITA and respects gender parity as much as possible. He has a coordinator in his midst. The duration of his mandate is that of the quinquennium of the Unit. The list of members is confirmed annually by the Council of the center and updated in case of replacement of one of the members. Depending on the needs and circumstances, the CEIS may appoint one or two experts from outside the IRC for the duration of a mediation.
- Art 2: The CEIS can be seized at any time by any staff of the CRI and thus can also self-poll a question.
- Art 3: The CEIS seized of a question informs the committee of direction of the CRI.
- Art 4: The members of the CEIS in conflict of interest in the context of a referral are excluded from the committee. Conflicts of interest are considered to be: a publication or patent that is less than five years old or in the process of being submitted, or that is underway or in the process of being submitted, in common with one of the protagonists of the conflict.
- Art 5: At the end of its mission, the CEIS reports on its findings through a report submitted to the IRC management committee and to the protagonists involved in the ethical issue or scientific integrity posed. Internal discussions at CEIS are and remain confidential. The report has advisory value and can be brought to the attention of the IRC.