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Physiopathology and treatment of viral hepatitis (VHEP)

Team Asselah

Department Hepato-Gastroenterology Department

 

Leader(s)

 

Line-up

Team Leader(s)

 

Presentation

The Team Project

Hepatitis B virus (HBV) infection remains a major global health concern as over 257 million individuals are estimated to be carriers of hepatitis B ‘surface’ antigen (HBsAg), the hallmark of chronic HBV infection (CHB). CHB has potential adverse outcomes, including cirrhosis, hepatic decompensation, and hepatocellular carcinoma.

The Hepatology team from Hospital Beaujon is a worldwide leader in clinical trials and has been successful in drug development for chronic hepatitis C, for which the team has been involved as a coordinator/principal investigator in several clinical trials. In particular the team coordinated major international clinical trials on HCV Genotype 4 infection.

The team project is currently working on HBV physiopathology and for strategies to achieve HBV cure. The team is involved as a coordinator/principal investigator in several clinical trials on drugs in development to fight against HBV infection. The team fields of research include also chronic liver diseases, translational medicine and treatment of HBV and HCV infections with new direct-acting antivirals.

The development of antibodies against HBsAg is a hallmark of the resolution of acute infection and is a therapeutic goal for the functional recovery of CHB. CHB causes exhaustion of virus-specific T cells, but its impact on humoral immunity has been poorly studied. The identification of T and B cell response mechanisms will provide a better understanding of their role in seroconversion of HBsAg.

Thanks to the expertise of Dr Abdellah Mansouri, the team has also a project on mitochondrial involvement in the pathophysiology of viral hepatitis. Mitochondria play important role in cellular antiviral defense because they serve as the platform for innate immune signaling and for inflammasome formation. The mitochondrial unfolded protein response (UPRmt, a recently discovered protein quality control pathway that resolves the mitochondrial stress by retrograde signaling to the nucleus) is characterized by transcriptional activation of innate immune and proinflammatory genes. Mitophagy and UPRmt may thus act as a negative modulator of mitochondrial antiviral protein (MAVS)-mediated innate immune signaling and may unravel how HBV or HCV usurp mitochondrial dysfunction to cripple the interferon synthesis, interferon responsive genes expression and cellular antiviral response. One of the objectives of the Team is thus to demonstrate viral involvement in mitochondrial dynamics (biogenesis, fission, fusion, mitophagy), function/dysfunction, oxidative stress and UPRmt. These studies may highlight the novel role of mitochondrial stresses in antiviral signaling and in the responses to the treatments. 

 

 

Landmark publications

  • Publication date : 06 June 2024 More

    Bulevirtide Combined with Pegylated Interferon for Chronic Hepatitis D
    New England Journal of Medecine

    Authors : Asselah Tarik Vladimir Chulanov Pietro Lampertico Heiner Wedemeyer Adrian Streinu-Cercel Victor Pântea Stefan Lazar Gheorghe Placinta George S Gherlan Pavel Bogomolov Tatyana Stepanova Viacheslav Morozov Vladimir Syutkin Olga Sagalova Dmitry Manuilov Renee-Claude Mercier Lei Ye Ben L Da Grace Chee Audrey H Lau Anu Osinusi Marc Bourliere Vlad Ratziu Stanislas Pol Marie-Noëlle Hilleret Fabien Zoulim Samuel Didier

  • Publication date : 09 September 2023 More

    Hepatitis-B virus: replication cycle, targets, and antiviral approaches
    Curr Opin Virol.

    Authors : Nour Nasser Pierre Tonnerre Mansouri Abdellah Asselah Tarik

  • Publication date : 01 August 2023 More

    Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries
    J Hepatol.

    Authors : Homie A Razavi Maria Buti Norah A Terrault Stefan Zeuzem Cihan Yurdaydin Junko Tanaka Alessio Aghemo Ulus S Akarca Nasser M Al Masri Abduljaleel M Alalwan Soo Aleman Abdullah S Alghamdi Saad Alghamdi Waleed K Al-Hamoudi Abdulrahman A Aljumah Ibrahim H Altraif Asselah Tarik Ziv Ben-Ari Thomas Berg Mia J Biondi Sarah Blach Wornei S M Braga Carlos E Brandão-Mello Maurizia R Brunetto Joaquin Cabezas Hugo Cheinquer Pei-Jer Chen Myeong-Eun Cheon Wan-Long Chuang Carla S Coffin Nicola Coppola Antonio Craxi Javier Crespo Victor De Ledinghen Ann-Sofi Duberg Ohad Etzion Maria Lucia G Ferraz Paulo R A Ferreira Xavier Forns Graham R Foster Giovanni B Gaeta Ivane Gamkrelidze Javier García-Samaniego Liliana S Gheorghe Pierre M Gholam Robert G Gish Jeffrey Glenn Julian Hercun Yao-Chun Hsu Ching-Chih Hu Jee-Fu Huang Naveed Janjua Jidong Jia Martin Kåberg Kelly D E Kaita Habiba Kamal Jia-Horng Kao Loreta A Kondili Martin Lagging Pablo Lázaro Jeffrey V Lazarus Mei-Hsuan Lee Young-Suk Lim Paul J Marotta Maria-Cristina Navas Marcelo C M Naveira Mauricio Orrego Carla Osiowy Calvin Q Pan Mário G Pessoa Giovanni Raimondo Alnoor Ramji Devin M Razavi-Shearer Kathryn Razavi-Shearer Cielo Y Ríos-Hincapié Manuel Rodríguez William M C Rosenberg Dominique M Roulot Stephen D Ryder Rifaat Safadi Faisal M Sanai Teresa A Santantonio Christoph Sarrazin Daniel Shouval Frank Tacke Tammo L Tergast Juan Miguel Villalobos-Salcedo Alexis S Voeller Hwai-I Yang Ming-Lung Yu Eli Zuckerman Polaris Observatory

  • Publication date : 06 July 2023 More

    Hepatitis D Virus Infection
    N Engl J Med.

    Authors : Asselah Tarik Mario Rizzetto

  • Publication date : 25 April 2023 More

    Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection
    J Hepatocell Carcinoma.

    Authors : Federico Costante Leonardo Stella Francesco Santopaolo Antonio Gasbarrini Maurizio Pompili Asselah Tarik Francesca Romana Ponziani

  • Publication date : 01 April 2023 More

    Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis
    Hepatology.

    Authors : Loureiro Dimitri Tout Issam Alex Narguet Stéphanie Bed Cheikh Mohamed Morgane Roinard Ahmad Sleiman Boyer Nathalie Pons-Kerjean Nathalie Castelnau Corinne Nathalie Giuly Dorothy Tonui Vassili Soumelis El Benna Jamel Patrick Soussan Moreau Richard Paradis Valérie Mansouri Abdellah Asselah Tarik

  • Publication date : 01 January 2023 More

    Hepatitis D virus: Improving virological knowledge to develop new treatments
    Antiviral Res.

    Authors : Pierre Khalfi Patrick T Kennedy Karim Majzoub Asselah Tarik

  • Publication date : 14 December 2022 More

    miRNAs as Potential Biomarkers for Viral Hepatitis B and C
    Viruses.

    Authors : Loureiro Dimitri Tout Issam Alex Narguet Stéphanie MENASRIA BENAZZOUZ Sabrina Mansouri Abdellah Asselah Tarik

  • Publication date : 24 November 2022 More

    Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection
    N Engl J Med.

    Authors : Man-Fung Yuen Seng-Gee Lim Robert Plesniak Keiji Tsuji Harry L A Janssen Cristina Pojoga Adrian Gadano Corneliu P Popescu Tatyana Stepanova Asselah Tarik Gheorghe Diaconescu Hyung Joon Yim Jeong Heo Ewa Janczewska Alexander Wong Nevin Idriz Michio Imamura Giuliano Rizzardini Koichi Takaguchi Pietro Andreone Manuela Arbune Jinlin Hou Sung Jae Park Andrei Vata Jennifer Cremer Robert Elston Tamara Lukić Geoff Quinn Lauren Maynard Stuart Kendrick Helene Plein Fiona Campbell Melanie Paff Dickens Theodore B-Clear Study Group

  • Publication date : 01 February 2022 More

    Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease
    Am J Gastroenterol.

    Authors : Patrice Cacoub Asselah Tarik

  • Publication date : 01 November 2021 More

    The Changing Demographics of Hepatitis B Virus Infection
    Clin Liver Dis.

    Authors : Tout Issam Alex Loureiro Dimitri Asselah Tarik

  • Publication date : 01 July 2021 More

    Early virological response in six patients with hepatitis D virus infection and compensated cirrhosis treated with Bulevirtide in real-life
    Liver Int.

    Authors : Asselah Tarik Loureiro Dimitri Fréderic Le Gal Narguet Stéphanie Ségolène Brichler Bouton Valérie Abazid Malek Boyer Nathalie Nathalie Giuly Athenais Gerber Tout Issam Alex Sarah Maylin Bed Cheikh Mohamed Marcellin Patrick Castelnau Corinne Emmanuel Gordien Mansouri Abdellah

  • Publication date : 01 June 2021 More

    New therapies for hepatitis delta virus infection
    Liver Int.

    Authors : Loureiro Dimitri Castelnau Corinne Tout Issam Alex Boyer Nathalie Narguet Stéphanie MENASRIA BENAZZOUZ Sabrina Louis Zeina Pons-Kerjean Nathalie Nathalie Giuly Marcellin Patrick Mansouri Abdellah Asselah Tarik

  • Publication date : 07 October 2020 More

    COVID-19: discovery, diagnostics and drug development
    Journal of Hepatology

    Authors : Asselah Tarik David Durantel Eric Pasmant George Lau Raymond F. Schinazi

  • Publication date : 01 August 2020 More

    Hepatitis B surface antigen seroclearance: Immune mechanisms, clinical impact, importance for drug development
    J Hepatol .

    Authors : Tout Issam Alex Loureiro Dimitri Mansouri Abdellah Vassili Soumelis Boyer Nathalie Asselah Tarik

  • Publication date : 01 November 2019 More

    Targets and future direct-acting antiviral approaches to achieve hepatitis B virus cure
    Lancet Gastroenterol Hepatol

    Authors : Asselah Tarik Loureiro Dimitri Boyer Nathalie Mansouri Abdellah

  • Publication date : 01 January 2019 More

    Efficacy and safety of glecaprevir/pibrentasvir in patients with chronic hepatitis C virus genotype 5 or 6 infection (ENDURANCE-5,6): an open-label, multicentre, phase 3b trial
    Lancet Gastroenterol Hepatol

    Authors : Asselah Tarik Samuel S Lee Betty B Yao Tuan Nguyen Florence Wong Adam Mahomed Seng Gee Lim Armand Abergel Joe Sasadeusz Edward Gane Neddie Zadeikis Gretja Schnell Zhenzhen Zhang Ariel Porcalla Federico J Mensa Kinh Nguyen

  • Publication date : 01 September 2018 More

    Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases
    Gastroenterology .

    Authors : Mansouri Abdellah Charles-Henry Gattolliat Asselah Tarik

  • Publication date : 01 April 2018 More

    Eliminating hepatitis C within low-income countries – The need to cure genotypes 4, 5, 6
    J Hepatol

    Authors : Asselah Tarik Tarek Hassanein Imam Waked Mansouri Abdellah Geoffrey Dusheiko Edward Gane

  • Publication date : 01 March 2018 More

    Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis
    Clin Gastroenterol Hepatol

    Authors : Asselah Tarik Kris V Kowdley Neddie Zadeikis Stanley Wang Tarek Hassanein Yves Horsmans Massimo Colombo Filipe Calinas Humberto Aguilar Victor de Ledinghen Parvez S Mantry Christophe Hezode Rui Tato Marinho Kosh Agarwal Frederik Nevens Magdy Elkhashab Jens Kort Ran Liu Teresa I Ng Preethi Krishnan Chih-Wei Lin Federico J Mensa

  • Publication date : 01 February 2018 More

    Treatment of hepatitis C virus infection with direct-acting antiviral agents: 100% cure?
    Liver Int .

    Authors : Asselah Tarik Marcellin Patrick Raymond F Schinazi

  • Publication date : 01 February 2018 More

    Towards HBV curative therapies
    Liver Int.

    Authors : Raymond F. Schinazi Maryam Ehteshami Leda Bassit Asselah Tarik

  • Publication date : 12 October 2016 More

    MicroRNA-based diagnostic tools for advanced fibrosis and cirrhosis in patients with chronic hepatitis B and C
    Scientific Reports

    Authors : Kevin Appourchaux Dokmak Safi Matthieu Resche-Rigon Treton Xavier Martine Lapalus Charles-Henry Gattolliat Emmanuelle Porchet Michelle Martinot-Peignoux Boyer Nathalie Michel Vidaud Bedossa Pierre Marcellin Patrick Ivan Bièche Emilie Estrabaud Asselah Tarik

  • Publication date : 01 June 2014 More

    Reduction of MicroRNA 122 Expression in IFNL3 CT/TT Carriers and during Progression of Fibrosis in Patients with Chronic Hepatitis C
    J Virol

    Authors : Estrabaud E Lapalus M Broët P Appourchaux K Muynck SD Lada O Martinot-Peignoux M Bièche I Valla Dominique Bedossa Pierre Marcellin Patrick Vidaud M Asselah Tarik

 
 

Site de référence pour les Appels à Projets


Les dernières publications marquantes

  • Publication date : 07 June 2024 More

    The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites
    Int Immunopharmacol.

    Authors : Tarek Boussetta Houssam Raad Bedouhene Samia Arabi-Derkawi Riad Gougerot-Pocidalo Marie-Anne Gilles Hayem Dang Pham My-Chan El Benna Jamel

  • Publication date : 02 May 2024 More

    BTK drives neutrophil activation for sterilizing antifungal immunity
    J Clin Invest.

    Authors : Jigar V Desai Marissa A Zarakas Andrew L Wishart Mark Roschewski Mariano A Aufiero Ágnes Donkó Gustaf Wigerblad Neta Shlezinger Markus Plate Matthew R James Jean K Lim Gulbu Uzel Jenna Re Bergerson Ivan Fuss Robert A Cramer Luis M Franco Emily S Clark Wasif N Khan Daisuke Yamanaka Georgios Chamilos El Benna Jamel Mariana J Kaplan Louis M Staudt Thomas L Leto Steven M Holland Wyndham H Wilson Tobias M Hohl Michail S Lionakis

  • Publication date : 01 May 2024 More

    Food additive emulsifiers and the risk of type 2 diabetes: analysis of data from the NutriNet-Santé prospective cohort study
    Lancet Diabetes Endocrinol.

    Authors : Clara Salame Guillaume Javaux Laury Sellem Viennois Emilie Fabien Szabo de Edelenyi Cédric Agaësse Alexandre De Sa Inge Huybrechts Fabrice Pierre Xavier Coumoul Chantal Julia Emmanuelle Kesse-Guyot Benjamin Allès Léopold K Fezeu Serge Hercberg Mélanie Deschasaux-Tanguy Emmanuel Cosson Sopio Tatulashvili Benoit Chassaing Bernard Srour Mathilde Touvier