Leader
-
Asselah Tarik
- 01 40 87 55 21
- tarik.Asselah@bjn.aphp.fr
The Team Project
Hepatitis B virus (HBV) infection remains a major global health concern as over 257 million individuals are estimated to be carriers of hepatitis B ‘surface’ antigen (HBsAg), the hallmark of chronic HBV infection (CHB). CHB has potential adverse outcomes, including cirrhosis, hepatic decompensation, and hepatocellular carcinoma.
The Hepatology team from Hospital Beaujon is a worldwide leader in clinical trials and has been successful in drug development for chronic hepatitis C, for which the team has been involved as a coordinator/principal investigator in several clinical trials. In particular the team coordinated major international clinical trials on HCV Genotype 4 infection.
The team project is currently working on HBV physiopathology and for strategies to achieve HBV cure. The team is involved as a coordinator/principal investigator in several clinical trials on drugs in development to fight against HBV infection. The team fields of research include also chronic liver diseases, translational medicine and treatment of HBV and HCV infections with new direct-acting antivirals.
The development of antibodies against HBsAg is a hallmark of the resolution of acute infection and is a therapeutic goal for the functional recovery of CHB. CHB causes exhaustion of virus-specific T cells, but its impact on humoral immunity has been poorly studied. The identification of T and B cell response mechanisms will provide a better understanding of their role in seroconversion of HBsAg.
Thanks to the expertise of Dr Abdellah Mansouri, the team has also a project on mitochondrial involvement in the pathophysiology of viral hepatitis. Mitochondria play important role in cellular antiviral defense because they serve as the platform for innate immune signaling and for inflammasome formation. The mitochondrial unfolded protein response (UPRmt, a recently discovered protein quality control pathway that resolves the mitochondrial stress by retrograde signaling to the nucleus) is characterized by transcriptional activation of innate immune and proinflammatory genes. Mitophagy and UPRmt may thus act as a negative modulator of mitochondrial antiviral protein (MAVS)-mediated innate immune signaling and may unravel how HBV or HCV usurp mitochondrial dysfunction to cripple the interferon synthesis, interferon responsive genes expression and cellular antiviral response. One of the objectives of the Team is thus to demonstrate viral involvement in mitochondrial dynamics (biogenesis, fission, fusion, mitophagy), function/dysfunction, oxidative stress and UPRmt. These studies may highlight the novel role of mitochondrial stresses in antiviral signaling and in the responses to the treatments.
Publication date : 09 September 2023 More
Autors : Nour Nasser Pierre Tonnerre Mansouri Abdellah Asselah Tarik
Publication date : 01 August 2023 More
Autors : Homie A Razavi Maria Buti Norah A Terrault Stefan Zeuzem Cihan Yurdaydin Junko Tanaka Alessio Aghemo Ulus S Akarca Nasser M Al Masri Abduljaleel M Alalwan Soo Aleman Abdullah S Alghamdi Saad Alghamdi Waleed K Al-Hamoudi Abdulrahman A Aljumah Ibrahim H Altraif Asselah Tarik Ziv Ben-Ari Thomas Berg Mia J Biondi Sarah Blach Wornei S M Braga Carlos E Brandão-Mello Maurizia R Brunetto Joaquin Cabezas Hugo Cheinquer Pei-Jer Chen Myeong-Eun Cheon Wan-Long Chuang Carla S Coffin Nicola Coppola Antonio Craxi Javier Crespo Victor De Ledinghen Ann-Sofi Duberg Ohad Etzion Maria Lucia G Ferraz Paulo R A Ferreira Xavier Forns Graham R Foster Giovanni B Gaeta Ivane Gamkrelidze Javier García-Samaniego Liliana S Gheorghe Pierre M Gholam Robert G Gish Jeffrey Glenn Julian Hercun Yao-Chun Hsu Ching-Chih Hu Jee-Fu Huang Naveed Janjua Jidong Jia Martin Kåberg Kelly D E Kaita Habiba Kamal Jia-Horng Kao Loreta A Kondili Martin Lagging Pablo Lázaro Jeffrey V Lazarus Mei-Hsuan Lee Young-Suk Lim Paul J Marotta Maria-Cristina Navas Marcelo C M Naveira Mauricio Orrego Carla Osiowy Calvin Q Pan Mário G Pessoa Giovanni Raimondo Alnoor Ramji Devin M Razavi-Shearer Kathryn Razavi-Shearer Cielo Y Ríos-Hincapié Manuel Rodríguez William M C Rosenberg Dominique M Roulot Stephen D Ryder Rifaat Safadi Faisal M Sanai Teresa A Santantonio Christoph Sarrazin Daniel Shouval Frank Tacke Tammo L Tergast Juan Miguel Villalobos-Salcedo Alexis S Voeller Hwai-I Yang Ming-Lung Yu Eli Zuckerman Polaris Observatory
Publication date : 06 July 2023 More
Autors : Asselah Tarik Mario Rizzetto
Publication date : 25 April 2023 More
Autors : Federico Costante Leonardo Stella Francesco Santopaolo Antonio Gasbarrini Maurizio Pompili Asselah Tarik Francesca Romana Ponziani
Publication date : 01 April 2023 More
Autors : Loureiro Dimitri Tout Issam Alex Narguet Stéphanie Bed Cheikh Mohamed Morgane Roinard Ahmad Sleiman Boyer Nathalie Pons-Kerjean Nathalie Castelnau Corinne Nathalie Giuly Dorothy Tonui Vassili Soumelis El Benna Jamel Patrick Soussan Moreau Richard Paradis Valérie Mansouri Abdellah Asselah Tarik
Publication date : 01 January 2023 More
Autors : Pierre Khalfi Patrick T Kennedy Karim Majzoub Asselah Tarik
Publication date : 14 December 2022 More
Autors : Loureiro Dimitri Tout Issam Alex Narguet Stéphanie MENASRIA BENAZZOUZ Sabrina Mansouri Abdellah Asselah Tarik
Publication date : 24 November 2022 More
Autors : Man-Fung Yuen Seng-Gee Lim Robert Plesniak Keiji Tsuji Harry L A Janssen Cristina Pojoga Adrian Gadano Corneliu P Popescu Tatyana Stepanova Asselah Tarik Gheorghe Diaconescu Hyung Joon Yim Jeong Heo Ewa Janczewska Alexander Wong Nevin Idriz Michio Imamura Giuliano Rizzardini Koichi Takaguchi Pietro Andreone Manuela Arbune Jinlin Hou Sung Jae Park Andrei Vata Jennifer Cremer Robert Elston Tamara Lukić Geoff Quinn Lauren Maynard Stuart Kendrick Helene Plein Fiona Campbell Melanie Paff Dickens Theodore B-Clear Study Group
Publication date : 01 February 2022 More
Autors : Patrice Cacoub Asselah Tarik
Publication date : 01 November 2021 More
Autors : Tout Issam Alex Loureiro Dimitri Asselah Tarik
Publication date : 01 July 2021 More
Autors : Asselah Tarik Loureiro Dimitri Fréderic Le Gal Narguet Stéphanie Ségolène Brichler Bouton Valérie Abazid Malek Boyer Nathalie Nathalie Giuly Athenais Gerber Tout Issam Alex Sarah Maylin Bed Cheikh Mohamed Marcellin Patrick Castelnau Corinne Emmanuel Gordien Mansouri Abdellah
Publication date : 01 June 2021 More
Autors : Loureiro Dimitri Castelnau Corinne Tout Issam Alex Boyer Nathalie Narguet Stéphanie MENASRIA BENAZZOUZ Sabrina Louis Zeina Pons-Kerjean Nathalie Nathalie Giuly Marcellin Patrick Mansouri Abdellah Asselah Tarik
Publication date : 07 October 2020 More
Autors : Asselah Tarik David Durantel Eric Pasmant George Lau Raymond F. Schinazi
Publication date : 01 August 2020 More
Autors : Tout Issam Alex Loureiro Dimitri Mansouri Abdellah Vassili Soumelis Boyer Nathalie Asselah Tarik
Publication date : 01 November 2019 More
Autors : Asselah Tarik Loureiro Dimitri Boyer Nathalie Mansouri Abdellah
Publication date : 01 January 2019 More
Autors : Asselah Tarik Samuel S Lee Betty B Yao Tuan Nguyen Florence Wong Adam Mahomed Seng Gee Lim Armand Abergel Joe Sasadeusz Edward Gane Neddie Zadeikis Gretja Schnell Zhenzhen Zhang Ariel Porcalla Federico J Mensa Kinh Nguyen
Publication date : 01 September 2018 More
Autors : Mansouri Abdellah Charles-Henry Gattolliat Asselah Tarik
Publication date : 01 April 2018 More
Autors : Asselah Tarik Tarek Hassanein Imam Waked Mansouri Abdellah Geoffrey Dusheiko Edward Gane
Publication date : 01 March 2018 More
Autors : Asselah Tarik Kris V Kowdley Neddie Zadeikis Stanley Wang Tarek Hassanein Yves Horsmans Massimo Colombo Filipe Calinas Humberto Aguilar Victor de Ledinghen Parvez S Mantry Christophe Hezode Rui Tato Marinho Kosh Agarwal Frederik Nevens Magdy Elkhashab Jens Kort Ran Liu Teresa I Ng Preethi Krishnan Chih-Wei Lin Federico J Mensa
Publication date : 01 February 2018 More
Autors : Asselah Tarik Marcellin Patrick Raymond F Schinazi
Publication date : 01 February 2018 More
Autors : Raymond F. Schinazi Maryam Ehteshami Leda Bassit Asselah Tarik
Publication date : 12 October 2016 More
Autors : Kevin Appourchaux Dokmak Safi Matthieu Resche-Rigon Treton Xavier Martine Lapalus Charles-Henry Gattolliat Emmanuelle Porchet Michelle Martinot-Peignoux Boyer Nathalie Michel Vidaud Bedossa Pierre Marcellin Patrick Ivan Bièche Emilie Estrabaud Asselah Tarik
Publication date : 26 March 2014 More
Autors : Estrabaud E Lapalus M Broët P Appourchaux K Muynck SD Lada O Martinot-Peignoux M Bièche I Valla Dominique Bedossa Pierre Marcellin Patrick Vidaud M Asselah Tarik