Presentation

The scientific axis “Immunology, Signaling and Cellular Dynamics” focuses on deciphering the cellular and molecular mechanisms involving immune cells in physiological and immunopathological processes. Immune dysregulation and the resulting local or systemic inflammation are involved in a large number of chronic diseases and also promote the development of tumors. The study of these dysregulations and their mechanisms allows us to better understand the occurrence of these diseases, the contribution of the different immune players in their development, to identify therapeutic targets and also to design innovative approaches such as immunotherapies or cellular therapies. We study the interactions of immune cells with each other and/or with stromal cells and the consequences of these interactions in terms of signaling and production of pro- and/or anti-inflammatory mediators. Our axis highlights the immunopathological processes underlying various pathologies such as certain autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, mixed connective tissue disease, Gougerot-Sjögren’s disease, etc.), anti-tumor immunity and the development of fibrosing diseases (renal, pulmonary, intestinal or hepatic), particularly in the context of hematological and/or dysimmune pathologies.

In collaboration with the two other axes of the center, our transdisciplinary approaches in close connection with the clinical services of Bichat hospital (Nephrology, Internal Medicine, Pneumology, Rheumatology, Gastroenterology, etc.) allow us to carry out fundamental, translational and clinical studies in order to identify innovative therapeutic strategies in the interest of patients suffering from these chronic inflammatory diseases.