Loredana SAVEANU & Samira BENADDA

Faculty of Medicine Xavier Bichat, Paris: “Role of endosomes in the activation of Fc receptors for immunoglobulins (FcyR)”.

Immunology Fellowship

Loredana SAVEANU, a doctor-educator, is an immunologist researcher at Inserm at the Xavier Bichat Faculty of Medicine. She has been research team leader for this project since 2015 at the Inflammation Research Center.

Samira BENADDA has been an engineer at Inserm for a dozen years and is responsible for a cellular imaging platform at the Inflammation Research Center. Since 2015, she has been conducting this research project in Dr. Saveanu’s team as part of a doctorate.

The CSR Behring Endowment Fund project for research is based on preliminary results that show that the Fc receptor, RFc gamma 1 or CD64, does not only signal to the membrane but also at the endosomal level, and especially in endosomes that contain the aminopeptidase IRAP (Insulin Responsive AminoPeptidase). The first objective of this project is to understand by which endocytic pathway the Fc receptor arrives in the IRAP endosomes. The second objective is to know the importance in vivo of this signaling at the endosomal level during activation at the Fc receptor, in particular by antibody-dependent cytotoxicity models. In the long term, this research would optimize monoclonal antibody-based therapies or use endosomal proteins as biomarkers to predict the efficacy of these therapies. This project involves the “APreT: Presentation of T-Cell Antigen” team at the Inflammation Research Center.

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