Publications

• Publication date : 28 September 2025 More

  Predictive value of metabolic state on PanNET response to mTOR inhibitors

  Endocr Relat Cancer

  Authors : Cros Jérome Margot Bucau Matthieu Tihy Maxime Palazzo Pierre Bourgoin Anais Chassac Albuquerque Miguel Sauvanet Alain Dokmak Safi Dioguardi Burgio Marco Paradis Valérie Olivia Hentic Ruszniewski Philippe De Mestier Louis Rebours Vinciane Couvelard Anne

• Publication date : 09 April 2025 More

  Protective role of oleic acid against palmitic acid-induced pancreatic fibrosis

  J Transl Med.

  Authors : Frendi Sonia Anaïs Chassac Véron Killian Raffenne Jérome Nicolle Rémy Albuquerque Miguel Paradis Valérie Couvelard Anne Cros Jérome Rebours Vinciane

• Publication date : 10 February 2025 More

  Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach

  J Pathol.

  Authors : Hilmi Marc Flore Delecourt Raffenne Jérome Bourega Taib Nelson Dusetti Juan Iovanna Yuna Blum Magali Richard Cindy Neuzillet Couvelard Anne Matthieu Tihy De Mestier Louis Rebours Vinciane Nicolle Rémy Cros Jérome

• Publication date : 05 September 2024 More

  Prognostic impact of the tumour microenvironment in intrahepatic cholangiocarcinoma: identification of a peritumoural fibro-immune interface

  Virchows Arch.

  Authors : Gwladys Lubuela Beaufrère Aurélie Albuquerque Miguel Camille Pignollet Nicolle Rémy Lesurtel Mickaël Bouattour Mohamed Cros Jérome Paradis Valérie

• Publication date : 18 March 2024 More

  Role of the fatty pancreatic infiltration in pancreatic oncogenesis

  Sci Rep.

  Authors : Frendi Sonia Chloé Martineau Cazier Hélène Nicolle Rémy Anaïs Chassac Albuquerque Miguel Raffenne Jérome Le Faouder Julie Paradis Valérie Cros Jérome Couvelard Anne Rebours Vinciane

• Publication date : 30 November 2023 More

  The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy

  Lancet Gastroenterol Hepatol.

  Authors : Hilmi Marc Matthieu Delaye Milena Muzzolini Nicolle Rémy Cros Jérome Hammel Pascal Victoire Cardot-Ruffino Cindy Neuzillet

• Publication date : 13 November 2023 More

  Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial

  J Clin Oncol.

  Authors : Nicolle Rémy Jean-Baptiste Bachet Alexandre Harlé Juan Iovanna Hammel Pascal Rebours Vinciane Anthony Turpin Meher Ben Abdelghani Alice Wei Emmanuel Mitry Anthony Lopez James Biagi Eric François Pascal Artru Aurélien Lambert Daniel J Renouf Laure Monard Marjorie Mauduit Nelson Dusetti Thierry Conroy Cros Jérome

• Publication date : 12 June 2023 More

  Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma

  Nat Commun.

  Authors : Charlie Saillard Flore Delecourt Benoit Schmauch Olivier Moindrot Magali Svrcek Armelle Bardier-Dupas Jean Francois Emile Mira Ayadi Rebours Vinciane De Mestier Louis Hammel Pascal Cindy Neuzillet Jean Baptiste Bachet Juan Iovanna Nelson Dusetti Yuna Blum Magali Richard Yasmina Kermezli Paradis Valérie Mikhail Zaslavskiy Pierre Courtiol Aurelie Kamoun Nicolle Rémy Cros Jérome

• Publication date : 31 August 2022 More

  Molecular deciphering of primary liver neuroendocrine neoplasms confirms their distinct existence with foregut-like profile

  J Pathol.

  Authors : De Mestier Louis Nicolle Rémy Poté Nicolas Rebours Vinciane Cauchy François Olivia Hentic Frédérique Maire Ronot Maxime Lebtahi Rachida Sauvanet Alain Paradis Valérie Ruszniewski Philippe Couvelard Anne Cros Jérome

• Publication date : 04 January 2022 More

  PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

  BioRXiv

  Authors : C. Saillard F. Delecourt B. Schmauch O. Moindrot M. Svrcek A. Bardier-Dupas J-F. Emile M. Ayadi V. Rebours L. de Mestier P. Hammel C. Neuzillet J-B. Bachet J. Iovanna N. Dusetti Y. Blum M. Richard Y. Kermezli Paradis Valérie M. Zaslavskiy P. Courtiol A. Kamoun Nicolle Rémy Cros Jérome

• Publication date : 17 March 2021 More

  Tumour and stroma RNA signatures predict more accurately distant recurrence than clinicopathological factors in resected pancreatic adenocarcinoma

  Eur J Cancer .

  Authors : Hilmi Marc Cros Jérome Francesco Puleo Jeremy Augustin Jean-Francois Emile Magali Svrcek Hammel Pascal Tatjana Arsenijevic Jean-Luc Van Laethem Jean-Baptiste Bachet Nicolle Rémy

• Publication date : 10 March 2021 More

  Pancreatic Ductal Adenocarcinoma Arising in Young and Old Patients Displays Similar Molecular Features

  Cancers (Basel) .

  Authors : Raffenne Jérome Fernando A Martin Rémy Nicolle Marina Konta Yuna Blum Jérôme Torrisani Francesco Puleo Jean Baptiste Bachet Magali Svrcek Armel Bardier-Dupas Jean Francois Emile Peter Demetter Miroslav Radman Jean Luc Van Laethem Hammel Pascal Rebours Vinciane Paradis Valérie Couvelard Anne Cros Jérome

• Publication date : 10 November 2020 More

  A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma

  Annals of Oncology.

  Authors : Nicolle Rémy O. Gayet P. Duconseil C. Vanbrugghe J. Roques M. Bigonnet Y. Blum N. Elarouci L. Armenoult M. Ayadi A. de Reyniès F. Puleo J. Augustin J.F. Emile M. Svrcek T. Arsenijevic P. Hammel M. Giovannini P. Grandval L. Dahan V. Moutardier M. Gilabert J.L. Van Laethem J.B. Bachet Cros Jérome J. Iovanna N.J. Dusetti

• Publication date : 02 July 2020 More

  Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

  EBioMedicine.

  Authors : Nicolle Rémy Yuna Blum Pauline Duconseil Charles Vanbrugghe Nicolas Brandone Flora Poizat Julie Roques Martin Bigonnet Odile Gayet Marion Rubis Nabila Elarouci Lucile Armenoult Mira Ayadi Aurélien de Reyniès Marc Giovannini Philippe Grandval Stephane Garcia Cindy Canivet Cros Jérome Barbara Bournet Louis Buscail BACAP Consortium Vincent Moutardier Marine Gilabert Juan Iovanna Nelson Dusetti

• Publication date : 12 January 2020 More

  The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma

  Liver Int.

  Authors : Poté Nicolas Cros Jérome Laouirem Samira Raffenne Jérome Negrão M Albuquerque Miguel Bedossa Pierre Godinho Ferreira M Ait Si Ali S Fior R Paradis Valérie

• Publication date : 17 November 2019 More

  hENT1 Testing in Pancreatic Ductal Adenocarcinoma: Are We Ready? A Multimodal Evaluation of hENT1 Status

  Cancers (Basel).

  Authors : Raffenne Jérome Nicolle R Puleo F Le Corre D Boyez C Marechal R Emile JF Demetter P Bardier A Laurent-Puig P De Mestier Louis Paradis Valérie Couvelard Anne VanLathem JL MacKey JR Bachet JB Svrcek M Cros Jérome

• Publication date : 30 April 2019 More

  Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

  J Pathol.

  Authors : Cindy Neuzillet Annemilaï Tijeras-Raballand Chanthirika Ragulan Cros Jérome Yatish Patil Matthieu Martinet Mert Erkan Jörg Kleeff Jeremy Wilson Minoti Apte Marie Tosolini Abigail S Wilson Francesca R Delvecchio Corinne Bousquet Paradis Valérie Hammel Pascal Anguraj Sadanandam Hemant M Kocher

• Publication date : 31 March 2019 More

  Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome.

  Oncogene.

  Authors : Laouirem Samira Sannier A Norkowski E Cauchy F Doblas Sabrina Rautou Pierre-Emmanuel Albuquerque Miguel Garteiser Philippe Sognigbé L Raffenne Jérome Van Beers Bernard Soubrane Olivier Bedossa Pierre Cros Jérome Paradis Valérie

• Publication date : 20 January 2019 More

  Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset

  Cancers (Basel).

  Authors : Nicolle Rémy Raffenne Jérome Paradis Valérie Couvelard Anne Aurelien de Reynies Yuna Blum Cros Jérome

• Publication date : 31 December 2018 More

  Proteomic Landscape of Cholangiocarcinomas Reveals Three Different Subgroups According to Their Localization and the Aspect of Non-Tumor Liver.

  Proteomics Clin Appl.

  Authors : Le Faouder Julie Gigante E Léger T Albuquerque Miguel Beaufrère A Soubrane Olivier Dokmak S Camadro JM Cros Jérome Paradis Valérie

• Publication date : 31 March 2018 More

  Contribution of virtual biopsy to the screening of microvascular invasion in hepatocellular carcinoma: A pilot study

  Liver Int.

  Authors : Poté Nicolas Cauchy François Albuquerque Miguel Cros Jérome Soubrane Olivier Bedossa Pierre Paradis Valérie

• Publication date : 08 January 2018 More

  In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma.

  Oncotarget.

  Authors : Dayot Stephanie Speisky D Couvelard Anne Bourgoin P Gratio Valérie Cros Jérome Rebours Vinciane Sauvanet Alain Bedossa Pierre Paradis Valérie Ruszniewski Philippe Couvineau Alain Voisin Thierry