Leader(s)

• 

  De Chaisemartin Luc

  • 01 40 25 85 21
  • luc.de-chaisemartin@aphp.fr
• 

  Launay Pierre

  • 01 57 27 77 47
  • pierre.launay@inserm.fr

Presentation

The main objective of the InnaLUNG team is to address clinical complications related to inflammatory lung diseases from the perspective of innate immunity. Our goal is to decipher the inflammatory pathways involved to identify new therapeutic targets and diagnostic/prognostic markers in two pathologies: severe asthma and primary graft dysfunction.

In severe asthma, acute exacerbations account for the majority of the disease-associated morbidity and mortality. Through multi-omics immunoprofiling studies, we aim to determine the contribution of innate immunity to exacerbation susceptibility in severe asthma, with the objective of identifying potential targets for diagnosis or therapeutic intervention. The physiological relevance of these targets will be validated in two murine models of different pathophysiological mechanisms.

In lung transplantation (LT), we will investigate early postoperative inflammatory mechanisms to identify the key cells and molecules involved in primary graft dysfunction. Alongside exploratory translational studies, we will establish a human ex vivo lung transplantation model using grafts disqualified for therapeutic transplantation, connected to an ex vivo ventilation and perfusion machine (XVIVO®). Additionally, we will develop an orthotopic murine transplantation model to further explore the role of innate immunity in host-graft interactions. This combination of approaches will enable us to precisely understand the early inflammatory events in lung inflammation and the associated innate immunity parameters. This knowledge will allow us to consider patient stratification strategies based on their immune status, coupled with innovative therapeutic interventions, ultimately aiming to improve the management and reduce the morbidity and mortality associated with these pathologies.

These resolutely translational themes align with the central focus of the unit, which is research on inflammation in human pathology, particularly within the major axis “Pathophysiology of inflammatory and fibrotic diseases.”