Auteurs

Rémy Nicolle,
Jean-Baptiste Bachet,
Alexandre Harlé,
Juan Iovanna,
Pascal Hammel,
Vinciane Rebours,
Anthony Turpin,
Meher Ben Abdelghani,
Alice Wei,
Emmanuel Mitry,
Anthony Lopez,
James Biagi,
Eric François,
Pascal Artru,
Aurélien Lambert,
Daniel J Renouf,
Laure Monard,
Marjorie Mauduit,
Nelson Dusetti,
Thierry Conroy,
Jérome Cros,
 
This study evaluates the value of a transcriptomic signature, GemPred, to predict gemcitabine sensitivity in patients with resected pancreatic ductal adenocarcinoma (PDAC). This signature provides evidence of the possibility to uncover and apply clinically phenotyping tools for personalized medicine.
 
The study demonstrated that patients classified as GemPred+, indicating a high likelihood of gemcitabine response, experienced significantly better disease-free and cancer-specific survival compared to those categorized as GemPred–. GemPred+ patients exhibited similar survival outcomes regardless of whether they received gemcitabine or a more aggressive chemotherapy regimen.
 
These findings highlight the potential of GemPred and more generally the transcriptome to guides patient treatment decisions, enabling to select the most effective and least toxic therapy for each individual patient. 

Autres publications

Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach

J Pathol.
11 Fév 2025
Auteurs :
Marc Hilmi,
Flore Delecourt,
Jérome Raffenne,
Taib Bourega,
Nelson Dusetti,
Juan Iovanna,
Yuna Blum,
Magali Richard,
Cindy Neuzillet,
Anne Couvelard,
Matthieu Tihy,
Mestier Louis De,
Vinciane Rebours,
Rémy Nicolle,
Jérome Cros,
En savoir +

The genomic and transcriptomic landscape of metastastic urothelial cancer

Nat Commun.
04 Oct 2024
Auteurs :
Yohann Loriot,
Maud Kamal,
Laurene Syx,
Rémy Nicolle,
Celia Dupain,
Naoual Mensourri,
Igor Duquesne,
Pernelle Lavaud,
Claudio Nicotra,
Maud Ngocamus,
Ludovic Lacroix,
Lambros Tselikas,
Gilles Crehange,
Luc Friboulet,
Zahra Castel-Ajgal,
Yann Neuzillet,
Edith Borcoman,
Philippe Beuzeboc,
Grégoire Marret,
Tom Gutman,
Jennifer Wong,
Francois Radvanyi,
Sylvain Dureau,
Jean-Yves Scoazec,
Nicolas Servant,
Yves Allory,
Benjamin Besse,
Fabrice Andre,
Christophe Le Tourneau,
Christophe Massard,
Ivan Bieche,
En savoir +

The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy

Lancet Gastroenterol Hepatol.
01 Déc 2023
Auteurs :
Marc Hilmi,
Matthieu Delaye,
Milena Muzzolini,
Rémy Nicolle,
Jérome Cros,
Pascal Hammel,
Victoire Cardot-Ruffino,
Cindy Neuzillet,
En savoir +

PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

BioRXiv
05 Jan 2022
Auteurs :
[:fr]C. Saillard[:],
[:fr]F. Delecourt[:],
[:fr]B. Schmauch[:],
[:fr]O. Moindrot[:],
[:fr]M. Svrcek[:],
[:fr]A. Bardier-Dupas[:],
[:fr]J-F. Emile[:],
[:fr]M. Ayadi[:],
[:fr]V. Rebours[:],
[:fr]L. de Mestier[:],
[:fr]P. Hammel[:],
[:fr]C. Neuzillet[:],
[:fr]J-B. Bachet[:],
[:fr]J. Iovanna[:],
[:fr]N. Dusetti[:],
[:fr]Y. Blum[:],
[:fr]M. Richard[:],
[:fr]Y. Kermezli[:],
Valérie Paradis,
[:fr]M. Zaslavskiy[:],
[:fr]P. Courtiol[:],
[:fr]A. Kamoun[:],
Rémy Nicolle,
Jérome Cros,
En savoir +