[:en]
Abstract
In recent years, there have been major advances in our understanding of the mechanisms underlying fibrosis progression and regression, and how coordinated interactions between parenchymal and non-parenchymal cells impact on the fibrogenic process. Recent studies have highlighted that metabolic reprogramming of parenchymal cells, immune cells (immunometabolism) and hepatic stellate cells is required to support the energetic and anabolic demands of phenotypic changes and effector functions. In this review, we summarise how targeting cell-intrinsic metabolic modifications of the main fibrogenic cell actors may impact on fibrosis progression and we discuss the antifibrogenic potential of metabolically targeted interventions.
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Other publications
01 Jul 2021
Authors :
Moreau Richard,
[:fr]Bin Gao[:],
[:fr]Maria Papp[:],
[:fr]Rafael Bañares[:],
[:fr]Patrick S Kamath[:],
Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF
[:fr]Front Immunol.[:]
05 Feb 2021
Authors :
Weiss Emmanuel,
Pierre de la Grange,
Mylène Defaye,
Juan José Lozano,
Ferrán Aguilar,
Pushpa Hegde,
Ariane Jolly,
Moga Lucile,
Sukriti Sukriti,
Banwari Agarwal,
Haqeeqat Gurm,
Tanguy Marion,
Poisson Johanne,
Joan Clària,
Paer-Selim Abback,
Perianin Axel,
Gautam Mehta,
Rajiv Jalan,
Francoz Claire,
Rautou Pierre-Emmanuel,
Lotersztajn Sophie,
Vicente Arroyo,
Durand François,
Moreau Richard,
LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling.
Sci Transl Med
15 Apr 2020
Authors :
Wan Jinghong,
Weiss Emmanuel,
Ben Mkaddem Sanae,
Mabire Morgane,
[:en]Pierre-Marie Choinier[:],
[:en] Olivia Picq[:],
[:en]Tristan Thibault-Sogorb[:],
[:en]Pushpa Hegde[:],
[:en]Dorsa Pishvaie[:],
Bens Marcelle,
[:en]Linda Broer[:],
Gilgenkrantz Hélène,
Moreau Richard,
Saveanu Loredana,
[:en]Patrice Codogno[:],
Monteiro Renato,
Lotersztajn Sophie,