Molecular and Clinical Features of Hepatocellular Carcinoma in Patients with HBV-HDV Infection

Authors

Federico Costante,

Leonardo Stella,

Francesco Santopaolo,

Antonio Gasbarrini,

Maurizio Pompili,

Asselah Tarik,

Francesca Romana Ponziani,

Abstract

Hepatitis D virus (HDV) infection affects more than 10 million people worldwide, with an estimated prevalence of nearly 4.5% among HBsAg-positive individuals. Epidemiological studies have shown a significant increase in the prevalence of hepatocellular carcinoma (HCC) in patients with chronic HDV infection compared to those with chronic hepatitis B virus (HBV) mono-infection. Despite the clinical findings, data on molecular oncogenic mechanisms are limited and fragmentary. Moreover, the role of HDV in promoting the development of HCC has so far been controversial, because it is difficult to weigh the respective contributions of the two viruses. In this review, we focused on the direct oncogenic action of HDV, its role in modifying the tumor microenvironment, and the genetic signature of HDV-related HCC, comparing these features with HBV-related HCC.

Other publications

Hepatitis-B virus: replication cycle, targets, and antiviral approaches

Curr Opin Virol.

Publication date :

08 Sep 2023

Authors :

Nour Nasser,

Pierre Tonnerre ,

Mansouri Abdellah,

Asselah Tarik,

Find out more

Hepatitis D double reflex testing of all hepatitis B carriers in low-HBV- and high-HBV/HDV-prevalence countries

J Hepatol.

Publication date :

31 Jul 2023

Authors :

Homie A Razavi,

Maria Buti,

Norah A Terrault,

Stefan Zeuzem,

Cihan Yurdaydin,

Junko Tanaka,

Alessio Aghemo,

Ulus S Akarca,

Nasser M Al Masri,

Abduljaleel M Alalwan,

Soo Aleman,

Abdullah S Alghamdi,

Saad Alghamdi,

Waleed K Al-Hamoudi,

Abdulrahman A Aljumah,

Ibrahim H Altraif,

Asselah Tarik,

Ziv Ben-Ari,

Thomas Berg,

Mia J Biondi,

Sarah Blach,

Wornei S M Braga,

Carlos E Brandão-Mello,

Maurizia R Brunetto,

Joaquin Cabezas,

Hugo Cheinquer,

Pei-Jer Chen,

Myeong-Eun Cheon,

Wan-Long Chuang,

Carla S Coffin,

Nicola Coppola,

Antonio Craxi,

Javier Crespo,

Victor De Ledinghen,

Ann-Sofi Duberg,

Ohad Etzion,

Maria Lucia G Ferraz,

Paulo R A Ferreira,

Xavier Forns,

Graham R Foster,

Giovanni B Gaeta,

Ivane Gamkrelidze,

Javier García-Samaniego,

Liliana S Gheorghe,

Pierre M Gholam,

Robert G Gish,

Jeffrey Glenn,

Julian Hercun,

Yao-Chun Hsu,

Ching-Chih Hu,

Jee-Fu Huang,

Naveed Janjua,

Jidong Jia,

Martin Kåberg,

Kelly D E Kaita,

Habiba Kamal,

Jia-Horng Kao,

Loreta A Kondili,

Martin Lagging,

Pablo Lázaro,

Jeffrey V Lazarus,

Mei-Hsuan Lee,

Young-Suk Lim,

Paul J Marotta,

Maria-Cristina Navas,

Marcelo C M Naveira,

Mauricio Orrego,

Carla Osiowy,

Calvin Q Pan,

Mário G Pessoa,

Giovanni Raimondo,

Alnoor Ramji,

Devin M Razavi-Shearer,

Kathryn Razavi-Shearer,

Cielo Y Ríos-Hincapié,

Manuel Rodríguez,

William M C Rosenberg,

Dominique M Roulot,

Stephen D Ryder,

Rifaat Safadi,

Faisal M Sanai,

Teresa A Santantonio,

Christoph Sarrazin,

Daniel Shouval,

Frank Tacke,

Tammo L Tergast ,

Juan Miguel Villalobos-Salcedo,

Alexis S Voeller,

Hwai-I Yang,

Ming-Lung Yu,

Eli Zuckerman,

Polaris Observatory,

Find out more

Hepatitis D Virus Infection

N Engl J Med.

Publication date :

05 Jul 2023

Authors :

Asselah Tarik,

Mario Rizzetto,

Find out more

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology.

Publication date :

31 Mar 2023

Authors :

Loureiro Dimitri,

Tout Issam Alex,

Narguet Stéphanie,

Bed Cheikh Mohamed,

Morgane Roinard,

Ahmad Sleiman,

Boyer Nathalie,

Pons-Kerjean Nathalie,

Castelnau Corinne,

Nathalie Giuly,

Dorothy Tonui,

Vassili Soumelis,

El Benna Jamel,

Patrick Soussan,

Moreau Richard,

Paradis Valérie,

Mansouri Abdellah,

Asselah Tarik,

Find out more