Publications

• Publication date : 23 April 2025 More

  Defective autophagy in CD4 T cells drives liver fibrosis via type 3 inflammation

  Nature Communications

  Authors : Al Sayegh Rola Wan Jinghong Caër Charles Azoulai Margot Maxime Gasperment Sukriti Baweja Marc-Anthony Chouillard Kandiah Janany Cadoux Mathilde Mabire Morgane Pignolet Camille Tristan Thibault-Sogorb Hammoutene Adel Paradis Valérie Saveanu Loredana Nicolle Rémy Gilgenkrantz Hélène Weiss Emmanuel Lotersztajn Sophie

• Publication date : 23 April 2025 More

  Integrin linked kinase and threonine tyrosine kinase modulate TCR signaling

  Sci Rep.

  Authors : Caillens Vivien Boisel Eva Ouksel Alycia Nugue Mathilde Evnouchidou Irini Saveanu Loredana

• Publication date : 31 March 2025 More

  Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two-sided nature of antagonistic ligands resulting from partial dissociation of Gq

  Br J Pharmacol.

  Authors : Gratio Valérie Paulina Dragan Garcia Laurine Saveanu Loredana Nicole Pascal Voisin Thierry Dorota Latek Couvineau Alain

• Publication date : 08 October 2024 More

  A new role for PI3Kγ in Fc receptor mediated cross-presentation

  Adv Sci (Weinh).

  Authors : Koumantou Despoina Aimé Cézaire Adiko Bourdely Pierre Nugue Mathilde Boedec Erwan El Benna Jamel Monteiro Renato Cosmin Saveanu Muriel Laffargue Matthias P Wymann Marc Dalod Guermonprez Pierre Saveanu Loredana

• Publication date : 08 October 2024 More

  Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs

  Adv Sci (Weinh).

  Authors : Koumantou Despoina Aimé Cézaire Adiko Bourdely Pierre Nugue Mathilde Boedec Erwan El Benna Jamel Monteiro Renato Cosmin Saveanu Muriel Laffargue Matthias P Wymann Marc Dalod Guermonprez Pierre Saveanu Loredana

• Publication date : 21 April 2024 More

  PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

  Nature Communications

  Authors : Tchen John Simon Quentin Chapart Lea Thaminy Morgane Vibhushan Shamila Saveanu Loredana Lamri Yasmine Saidoune Fanny Lebourdais-Pacreau Emeline Pellefigues Christophe Bex-Coudrat Julie Hajime KARASUYAMA Kensuke MIYAKE Juan HIDALGO Padraic G. FALLON Papo Thomas Blank Ulrich Benhamou Marc Hanouna Guillaume Sacre Karim Daugas Eric Charles Nicolas

• Publication date : 06 March 2024 More

  Identification of a Direct Role for Gut-Flora in Autoimmune Disease

  Sci Transl Med.

  Authors : Patrick J Gleeson Nicolas Benech Jonathan Chemouny Eleftheria Metallinou Laureline Berthelot Da silva Jennifer Bex-Coudrat Julie Boedec Erwan Fanny Canesi Bounaix Carine Willy Morelle Maryse Moya-Nilges John Kenny Liam O'Mahony Saveanu Loredana Bertrand Arnulf Aurélie Sannier Daugas Eric Vrtovsnik François Patricia Lepage Harry Sokol Monteiro Renato

• Publication date : 27 November 2023 More

  Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

  Cytometry A.

  Authors : Gratio Valérie Dayot Stephanie Benadda Samira Nicole Pascal Saveanu Loredana Voisin Thierry Couvineau Alain

• Publication date : 27 November 2023 More

  Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

  Cytometry A.

  Authors : Gratio Valérie Dayot Stephanie Benadda Samira Nicole Pascal Saveanu Loredana Voisin Thierry Couvineau Alain

• Publication date : 31 July 2023 More

  M1-aminopeptidase family – beyond antigen-trimming activities

  Curr Opin Immunol.

  Authors : Evnouchidou Irini Koumantou Despoina Nugue Mathilde Saveanu Loredana

• Publication date : 08 June 2023 More

  Activating FcγR function depends on endosomal-signaling platforms

  iScience.

  Authors : Benadda Samira Nugue Mathilde Koumantou Despoina Bens Marcelle Mariacristina De Luca Olivier Pellé Monteiro Renato Evnouchidou Irini Saveanu Loredana

• Publication date : 26 October 2022 More

  Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation

  Front Immunol.

  Authors : Bratti Manuela Vibhushan Shamila Cyril Longé Koumantou Despoina Gaël Ménasché Benhamou Marc Nadine Varin-Blank Blank Ulrich Saveanu Loredana Ben Mkaddem Sanae

• Publication date : 31 March 2022 More

  The role of endocytic trafficking in antigen T cell receptor activation

  Biomed J.

  Authors : Evnouchidou Irini Caillens Vivien Koumantou Despoina Saveanu Loredana

• Publication date : 19 October 2020 More

  The Role of Insulin Regulated Aminopeptidase in Endocytic Trafficking and Receptor Signaling in Immune Cells

  Front Mol Biosci.

  Authors : Delphyne Descamps Evnouchidou Irini Caillens Vivien Carole Drajac Sabine Riffault Peter van Endert Saveanu Loredana

• Publication date : 01 May 2020 More

  New players in the activation of T Lymphocytes

  Nature Communications

  Authors : Evnouchidou Irini Pascal Chappert Benadda Samira Andres Zucchetti Mirjana Weimershaus Bens Marcelle Caillens Vivien Despoina Koumantou Lotersztajn Sophie Peter van Endert Jean Davoust Guermonprez Pierre Claire Hivroz David A. Gross Saveanu Loredana

• Publication date : 01 May 2020 More

  IRAP-dependent endosomal T cell receptor signalling is essential for T cell responses

  Nat Commun.

  Authors : Evnouchidou Irini Pascal Chappert Benadda Samira Andres Zucchetti Mirjana Weimershaus Bens Marcelle Caillens Vivien Koumantou Despoina Lotersztajn Sophie Peter van Endert Jean Davoust Guermonprez Pierre Claire Hivroz David A Gross Saveanu Loredana

• Publication date : 14 April 2020 More

  LC3-associated phagocytosis protects against inflammation and liver fibrosis via immunoreceptor inhibitory signaling.

  Sci Transl Med

  Authors : Wan Jinghong Weiss Emmanuel Ben Mkaddem Sanae Mabire Morgane Pierre-Marie Choinier Olivia Picq Tristan Thibault-Sogorb Pushpa Hegde Dorsa Pishvaie Bens Marcelle Linda Broer Gilgenkrantz Hélène Moreau Richard Saveanu Loredana Patrice Codogno Monteiro Renato Lotersztajn Sophie

• Publication date : 01 August 2019 More

  Is there a place and role for endocytic TCR signaling?

  Immunol Rev.

  Authors : Saveanu Loredana Zucchetti AE Evnouchidou Irini Ardouin L Hivroz C

• Publication date : 19 March 2017 More

  IRAP+ endosomes restrict TLR9 activation and signaling

  Nat Immunol.

  Authors : Babdor J Descamps D Adiko AC Tohmé M Maschalidi S Evnouchidou Irini Vasconcellos LR De Luca M Mauvais FX Garfa-Traore M Brinkmann MM Chignard M Manoury B Saveanu Loredana

• Publication date : 16 July 2015 More

  Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets

  Front Immunol.

  Authors : Gutiérrez-Martínez E Planès R Anselmi G Reynolds M Menezes S Adiko AC Saveanu Loredana Guermonprez Pierre

• Publication date : 01 June 2015 More

  Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation

  Front Immunol.

  Authors : Adiko AC Babdor J Gutiérrez-Martínez E Guermonprez Pierre Saveanu Loredana