Publications

• Publication date : 28 September 2025 More

  Predictive value of metabolic state on PanNET response to mTOR inhibitors

  Endocr Relat Cancer

  Authors : Cros Jérome Margot Bucau Matthieu Tihy Maxime Palazzo Pierre Bourgoin Anais Chassac Albuquerque Miguel Sauvanet Alain Dokmak Safi Dioguardi Burgio Marco Paradis Valérie Olivia Hentic Ruszniewski Philippe De Mestier Louis Rebours Vinciane Couvelard Anne

• Publication date : 01 June 2025 More

  Revisiting hepatic small vessel neoplasms and anastomosing hemangiomas as a unique capillary liver neoplasm: a 25-case series with pathomolecular correlations

  Mod Pathol.

  Authors : Beaufrère Aurélie Astrid Laurent-Bellue Antoinette Lemoine Agnès Bourillon Nathalie Sturm Pierre Gosset Virginie Cahn Vilgrain Valérie Maité Lewin Paradis Valérie Catherine Guettier

• Publication date : 30 April 2025 More

  Hepatocellular carcinoma: Histological and molecular classifications

  Annales de Pathologie

  Authors : Beaufrère Aurélie Paradis Valérie

• Publication date : 23 April 2025 More

  Defective autophagy in CD4 T cells drives liver fibrosis via type 3 inflammation

  Nature Communications

  Authors : Al Sayegh Rola Wan Jinghong Caër Charles Azoulai Margot Maxime Gasperment Sukriti Baweja Marc-Anthony Chouillard Kandiah Janany Cadoux Mathilde Mabire Morgane Pignolet Camille Tristan Thibault-Sogorb Hammoutene Adel Paradis Valérie Saveanu Loredana Nicolle Rémy Gilgenkrantz Hélène Weiss Emmanuel Lotersztajn Sophie

• Publication date : 09 April 2025 More

  Protective role of oleic acid against palmitic acid-induced pancreatic fibrosis

  J Transl Med.

  Authors : Frendi Sonia Anaïs Chassac Véron Killian Raffenne Jérome Nicolle Rémy Albuquerque Miguel Paradis Valérie Couvelard Anne Cros Jérome Rebours Vinciane

• Publication date : 21 February 2025 More

  Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment

  JHEP Rep.

  Authors : Rautou Pierre-Emmanuel Shivani Chotkoe Biquard Louise Guillaume Wettstein Denise van der Graaff Yao Liu Joris De Man Christophe Casteleyn Sofie Thys Winnok H De Vos Bedossa Pierre Michael P Cooreman Martine Baudin Jean-Louis Abitbol Philippe Huot-Marchand Lucile Dzen Albuquerque Miguel Pierre Broqua Jean-Louis Junien Luisa Vonghia Manal F Abdelmalek Wilhelmus J Kwanten Paradis Valérie Sven M Francque

• Publication date : 16 February 2025 More

  Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment

  JHEP Reports

  Authors : Rautou Pierre-Emmanuel Shivani Chotkoe Biquard Louise Guillaume Wettstein Denise Van der Graaff Yao Liu Joris De Man Christophe Casteleyn Sofie Thys Winnok H. De Vos Bedossa Pierre Michael P. Cooreman Martine Baudin JeanLouis Abitbol Philippe Huot-Marchand Lucile Dzen Albuquerque Miguel Pierre Broqua Jean-Louis Junien Luisa Vonghia Manal F. Abdelmalek Wilhelmus J. Kwanten Paradis Valérie Sven M. Francque

• Publication date : 12 October 2024 More

  Entamoeba muris mitigates metabolic consequences of high-fat diet in mice

  Gut Microbes.

  Authors : Roy Maryline Dumay Anne Sandrine Adiba Sylvana Rozes Seiki Kobayashi Paradis Valérie Catherine Postic Dominique Rainteau Ogier-Denis Eric Le Gall Maude Meinzer Ulrich Viennois Emilie Casado-Bedmar Maite Alexis Mosca Hugot Jean-Pierre

• Publication date : 30 September 2024 More

  Orexins mitigate obesity-associated dysfunctions in mice

  Obesity (Silver Spring).

  Authors : Anne Blais Isabelle Denis Mireille Andriamihaja Gratio Valérie Gaelle Champeil-Potokar Laouirem Samira Anais Chassac Couvelard Anne Paradis Valérie Voisin Thierry Anne-Marie Davila Couvineau Alain

• Publication date : 05 September 2024 More

  Prognostic impact of the tumour microenvironment in intrahepatic cholangiocarcinoma: identification of a peritumoural fibro-immune interface

  Virchows Arch.

  Authors : Gwladys Lubuela Beaufrère Aurélie Albuquerque Miguel Camille Pignollet Nicolle Rémy Lesurtel Mickaël Bouattour Mohamed Cros Jérome Paradis Valérie

• Publication date : 18 March 2024 More

  Role of the fatty pancreatic infiltration in pancreatic oncogenesis

  Sci Rep.

  Authors : Frendi Sonia Chloé Martineau Cazier Hélène Nicolle Rémy Anaïs Chassac Albuquerque Miguel Raffenne Jérome Le Faouder Julie Paradis Valérie Cros Jérome Couvelard Anne Rebours Vinciane

• Publication date : 29 February 2024 More

  Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease is associated with heterogeneous pattern of fat infiltration in skeletal muscles

  Eur Radiol.

  Authors : Maxime Nachit Dioguardi Burgio Marco Abyzov Anton Garteiser Philippe Paradis Valérie Vilgrain Valérie Isabelle Leclercq Van Beers Bernard

• Publication date : 31 January 2024 More

  Artificial intelligence-assisted digital pathology for non-alcoholic steatohepatitis: current status and future directions

  J Hepatol

  Authors : Vlad Ratziu Marcus Hompesch Mathieu Petitjean Cindy Serdjebi Janani S Iyer Anil V Parwani Dean Tai Elisabetta Bugianesi Kenneth Cusi Scott L Friedman Eric Lawitz Manuel Romero-Gómez Detlef Schuppan Rohit Loomba Paradis Valérie Cynthia Behling Arun J Sanyal

• Publication date : 29 October 2023 More

  Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations

  Histopathology.

  Authors : Beaufrère Aurélie Paisley Sarah Ibrahima Ba Laouirem Samira Priori Victoria Cazier Hélène Loëtitia Favre Cauchy François Lesurtel Mickaël Julien Calderaro Kannengiesser Caroline Paradis Valérie

• Publication date : 30 September 2023 More

  Pathological overview of steatohepatitic hepatocellular carcinoma in a surgical series

  Histopathology.

  Authors : Loïc Trapani Beaufrère Aurélie Christian Hobeika Tatiana Codjia Albuquerque Miguel Mohamed Bouattour Lesurtel Mickaël Cauchy François Paradis Valérie

• Publication date : 11 July 2023 More

  A new NRF2 activator for the treatment of human metabolic dysfunction-associated fatty liver disease

  JHEP Rep.

  Authors : Hammoutene Adel Laouirem Samira Albuquerque Miguel Nathalie Colnot Brzustowski Angelique Valla Dominique Nicolas Provost Philippe Delerive Paradis Valérie QUID-NASH Research Group

• Publication date : 12 June 2023 More

  Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma

  Nat Commun.

  Authors : Charlie Saillard Flore Delecourt Benoit Schmauch Olivier Moindrot Magali Svrcek Armelle Bardier-Dupas Jean Francois Emile Mira Ayadi Rebours Vinciane De Mestier Louis Hammel Pascal Cindy Neuzillet Jean Baptiste Bachet Juan Iovanna Nelson Dusetti Yuna Blum Magali Richard Yasmina Kermezli Paradis Valérie Mikhail Zaslavskiy Pierre Courtiol Aurelie Kamoun Nicolle Rémy Cros Jérome

• Publication date : 08 June 2023 More

  Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis

  J Hepatol

  Authors : Elkrief Laure Nathalie Ganne-Carrié Manceau Hana Tanguy Marion Shantha Ram Valainathan Alix Riescher-Tuczkiewicz Biquard Louise Nathalie Barget Cendrine Chaffaut Alexandre Louvet Paradis Valérie Marianne Ziol Rikke Bæk Malene Møller Jørgensen Guillaume Van Niel Pierre-Michael Coly Hammoutene Adel Fanny Dujardin Katell Peoc'h Thierry Poynard Sylvie Chevret Rautou Pierre-Emmanuel CIRRAL group

• Publication date : 22 May 2023 More

  Cell metabolism-based therapy for liver fibrosis, repair and hepatocellular carcinoma

  Hepatology.

  Authors : Gilgenkrantz Hélène Paradis Valérie Lotersztajn Sophie

• Publication date : 15 May 2023 More

  Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

  JHEP Rep.

  Authors : Allaire Manon Al Sayegh Rola Mabire Morgane Hammoutene Adel Matthieu Siebert Caër Charles Cadoux Mathilde Wan Jinghong Habib Aida Le Gall Maude Pierre de la Grange Hervé Guillou Catherine Postic Paradis Valérie Lotersztajn Sophie Gilgenkrantz Hélène

• Publication date : 31 March 2023 More

  MALDI Imaging, a Powerful Multiplex Approach to Decipher Intratumoral Heterogeneity: Combined Hepato-Cholangiocarcinomas as Proof of Concept

  Cancers.

  Authors : Elia Gigante Cazier Hélène Albuquerque Miguel Laouirem Samira Beaufrère Aurélie Paradis Valérie

• Publication date : 31 March 2023 More

  Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

  Hepatology.

  Authors : Loureiro Dimitri Tout Issam Alex Narguet Stéphanie Bed Cheikh Mohamed Morgane Roinard Ahmad Sleiman Boyer Nathalie Pons-Kerjean Nathalie Castelnau Corinne Nathalie Giuly Dorothy Tonui Vassili Soumelis El Benna Jamel Patrick Soussan Moreau Richard Paradis Valérie Mansouri Abdellah Asselah Tarik

• Publication date : 31 March 2023 More

  MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

  Nature Commun.

  Authors : Mabire Morgane Pushpa Hegde Hammoutene Adel Wan Jinghong Caër Charles Al Sayegh Rola Cadoux Mathilde Weiss Emmanuel Tristan Thibault-Sogorb Olivier Lantz Michèle Goodhardt Paradis Valérie Pierre de la Grange Gilgenkrantz Hélène Lotersztajn Sophie

• Publication date : 31 January 2023 More

  Pathogenesis of primary liver carcinomas

  J Hepatol.

  Authors : Paradis Valérie Jessica Zucman-Rossi

• Publication date : 02 January 2023 More

  Management of splanchnic vein thrombosis

  JHEP Rep.

  Authors : Elkrief Laure Audrey Payancé Plessier Aurélie Louis d'Alteroche Ronot Maxime Paradis Valérie Valla Dominique Rautou Pierre-Emmanuel

• Publication date : 15 December 2022 More

  Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice

  JHep Reports

  Authors : Klaus Seedorf Csaba Weber Cedric Vinson Sylvie Berger Laurent-Michel Vuillard Arpad Kiss Stephanie Creusot Olivier Broux Anne Geant Catherine Ilic Karine Lemaitre Johann Richard Hammoutene Adel Julien Mahieux Virginie Martigny Didier Durand Fabien Melchiore Miklos Nyerges Paradis Valérie Nicolas Provost Valérie Duvivier Philippe Delerive

• Publication date : 29 November 2022 More

  Comparative Analysis of a Locally Resampling MR Elastography Reconstruction Algorithm in Liver Fibrosis

  JMRI

  Authors : Page Gwenael JULEA Felicia Paradis Valérie Vilgrain Valérie Valla Dominique Van Beers Bernard Garteiser Philippe

• Publication date : 31 August 2022 More

  Molecular deciphering of primary liver neuroendocrine neoplasms confirms their distinct existence with foregut-like profile

  J Pathol.

  Authors : De Mestier Louis Nicolle Rémy Poté Nicolas Rebours Vinciane Cauchy François Olivia Hentic Frédérique Maire Ronot Maxime Lebtahi Rachida Sauvanet Alain Paradis Valérie Ruszniewski Philippe Couvelard Anne Cros Jérome

• Publication date : 31 July 2022 More

  Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: A case-control study

  Hepatology.

  Authors : Shantha Ram Valainathan Sartoris Riccardo Elkrief Laure Marta Magaz Fabian Betancourt Silvia Pellegrino Arianna Nivolli Dioguardi Burgio Marco Yves Flattet Sylvain Terraz Nicolas Drilhon Marie Lazareth Julia Herrou Onorina Bruno Audrey Payance Plessier Aurélie Durand François Ronot Maxime Dominique-Charles Valla Paradis Valérie Juan Carlos Garcia-Pagan Vilgrain Valérie Rautou Pierre-Emmanuel

• Publication date : 24 July 2022 More

  Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

  Dev Cell.

  Authors : Romain Donne Maëva Saroul-Ainama Pierre Cordier Hammoutene Adel Christelle Kabore Mira Stadler Ivan Nemazanyy Isabelle Galy-Fauroux Mounia Herrag Tobias Riedl Marie Chansel-Da Cruz Stefano Caruso Stéphanie Bonnafous Rupert Öllinger Roland Rad Kristian Unger Albert Tran Jean-Pierre Couty Philippe Gual Paradis Valérie Séverine Celton-Morizur Mathias Heikenwalder Patrick Revy Chantal Desdouets

• Publication date : 30 March 2022 More

  Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs

  J Clin Exp Hepatol.

  Authors : Valérie Duvivier Stéphanie Creusot Olivier Broux Aurélie Helbert Ludovic Lesage Kevin Moreau Nicolas Lesueur Lindsay Gerard Karine Lemaitre Nicolas Provost Edwige-Ludiwyne Hubert Tania Baltauss Nathalie De Preville Julia Geronimi Lucie Adoux Franck Letourneur Hammoutene Adel Valla Dominique Paradis Valérie Philippe Delerive

• Publication date : 10 February 2022 More

  Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

  PLoS One.

  Authors : Patricia Sansilvestri Morel Valerie Duvivier Florence Bertin Nicolas Provost Hammoutene Adel Edwige-Ludiwyne Hubert Arantxa Gonzalez Isabelle Tupinon-Mathieu Paradis Valérie Philippe Delerive

• Publication date : 31 January 2022 More

  Gene expression signature as a surrogate marker of microvascular invasion on routine hepatocellular carcinoma biopsies

  J Hepatol.

  Authors : Beaufrère Aurélie Stefano Caruso Julien Calderaro Poté Nicolas Jean-Charles Bijot Gabielle Couchy Cauchy François Vilgrain Valérie Jessica Zucman-Rossi Paradis Valérie

• Publication date : 28 January 2022 More

  Contrast-enhanced CT and liver surface nodularity for the diagnosis of porto-sinusoidal vascular disorder: a case-control study

  Hepatology.

  Authors : Shantha Ram Valainathan Riccardo Sartoris Elkrief Laure Marta Magaz Fabian Betancourt Silvia Pellegrino Arianna Nivolli Dioguardi Burgio Marco Yves Flattet Sylvain Terraz Nicolas Drilhon Marie Lazareth Julia Herrou Onorina Bruno Audrey Payance Plessier Aurélie Durand François Ronot Maxime Valla Dominique Paradis Valérie Juan Carlos Garcia-Pagan Vilgrain Valérie Rautou Pierre-Emmanuel

• Publication date : 04 January 2022 More

  PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

  BioRXiv

  Authors : C. Saillard F. Delecourt B. Schmauch O. Moindrot M. Svrcek A. Bardier-Dupas J-F. Emile M. Ayadi V. Rebours L. de Mestier P. Hammel C. Neuzillet J-B. Bachet J. Iovanna N. Dusetti Y. Blum M. Richard Y. Kermezli Paradis Valérie M. Zaslavskiy P. Courtiol A. Kamoun Nicolle Rémy Cros Jérome

• Publication date : 30 June 2021 More

  Transarterial chemoembolisation enhances programmed death-1 and programmed death-ligand 1 expression in hepatocellular carcinoma

  Histopathology.

  Authors : Ahmed Montasser Beaufrère Aurélie Cauchy François Mohamed Bouattour Soubrane Olivier Albuquerque Miguel Paradis Valérie

• Publication date : 28 June 2021 More

  Long-term outcomes following resection of hepatocellular adenomas with small foci of malignant transformation or malignant adenomas

  JHEP Rep.

  Authors : Sophie Chopinet Cauchy François Christian Hobeika Beaufrère Aurélie Poté Nicolas Farges Olivier Dokmak Safi Mohamed Bouattour Ronot Maxime Vilgrain Valérie Paradis Valérie Soubrane Olivier

• Publication date : 10 March 2021 More

  Pancreatic Ductal Adenocarcinoma Arising in Young and Old Patients Displays Similar Molecular Features

  Cancers (Basel) .

  Authors : Raffenne Jérome Fernando A Martin Rémy Nicolle Marina Konta Yuna Blum Jérôme Torrisani Francesco Puleo Jean Baptiste Bachet Magali Svrcek Armel Bardier-Dupas Jean Francois Emile Peter Demetter Miroslav Radman Jean Luc Van Laethem Hammel Pascal Rebours Vinciane Paradis Valérie Couvelard Anne Cros Jérome

• Publication date : 20 December 2020 More

  Liver stiffness by transient elastography to detect porto-sinusoidal vascular liver disease with portal hypertension

  Hepatology

  Authors : Elkrief Laure Marie Lazareth Sylvie Chevret Paradis Valérie Marta Magaz Lorraine Blaise Laura Rubbia-Brandt Moga Lucile Durand François Audrey Payancé Plessier Aurélie Cendrine Chaffaut Valla Dominique Marion Malphettes Alba Diaz Jean-Charles Nault Pierre Nahon Etienne Audureau Vlad Ratziu Castera Laurent Juan-Carlos Garcia Pagan Nathalie Ganne-Carrie Rautou Pierre-Emmanuel ANRS CO12 CirVir group

• Publication date : 27 August 2020 More

  Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma

  Modern Pathology.

  Authors : Guedj Nathalie Lorraine Blaise Cauchy François Albuquerque Miguel Soubrane Olivier Paradis Valérie

• Publication date : 23 August 2020 More

  New insights into the pathophysiology and clinical care of rare primary liver cancers

  JHEP Rep.

  Authors : Elia Gigante Paradis Valérie Ronot Maxime Cauchy François Soubrane Olivier Nathalie Ganne-Carrié Jean-Charles Nault

• Publication date : 31 March 2020 More

  Quantification of hepatic steatosis with ultrasound: promising role of attenuation imaging coefficient in a biopsy-proven cohort

  Eur Radiol.

  Authors : Dioguardi Burgio Marco Ronot Maxime Edouard Reizine Rautou Pierre-Emmanuel Castera Laurent Paradis Valérie Garteiser Philippe Van Beers Bernard Vilgrain Valérie

• Publication date : 31 March 2020 More

  Comparison of pulsed and oscillating gradient diffusion-weighted MRI for characterizing hepatocellular nodules in liver cirrhosis: ex vivo study in a rat model

  J Magn Reson Imaging.

  Authors : Mathilde Wagner Doblas Sabrina Poté Nicolas Simon A Lambert Ronot Maxime Garteiser Philippe Paradis Valérie Vilgrain Valérie Van Beers Bernard

• Publication date : 29 February 2020 More

  A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis

  J Hepatol.

  Authors : Hammoutene Adel Biquard Louise Juliette Lasselin Marouane Kheloufi Tanguy Marion Anne-Clémence Vion Jules Mérian Nathalie Colnot Xavier Loyer Alain Tedgui Patrice Codogno Lotersztajn Sophie Paradis Valérie Chantal M Boulanger Rautou Pierre-Emmanuel

• Publication date : 12 January 2020 More

  The histone acetyltransferase hMOF promotes vascular invasion in hepatocellular carcinoma

  Liver Int.

  Authors : Poté Nicolas Cros Jérome Laouirem Samira Raffenne Jérome Negrão M Albuquerque Miguel Bedossa Pierre Godinho Ferreira M Ait Si Ali S Fior R Paradis Valérie

• Publication date : 30 December 2019 More

  Combining imaging and tumour biopsy improves the diagnosis of combined hepatocellular-cholangiocarcinoma

  Liver Int.

  Authors : Gigante E Ronot Maxime Bertin C Ciolina M Bouattour M Dondero F Cauchy F Soubrane Olivier Paradis Valérie

• Publication date : 18 December 2019 More

  Metabolic syndrome and hepatic surgery

  J Visc Surg. 2019 Dec 19. pii: S1878-7886(19)30180-8. doi: 10.1016/j.jviscsurg.2019.11.004

  Authors : Hobeika C Ronot Maxime Beaufrere A Paradis Valérie Soubrane Olivier Cauchy F

• Publication date : 17 November 2019 More

  hENT1 Testing in Pancreatic Ductal Adenocarcinoma: Are We Ready? A Multimodal Evaluation of hENT1 Status

  Cancers (Basel).

  Authors : Raffenne Jérome Nicolle R Puleo F Le Corre D Boyez C Marechal R Emile JF Demetter P Bardier A Laurent-Puig P De Mestier Louis Paradis Valérie Couvelard Anne VanLathem JL MacKey JR Bachet JB Svrcek M Cros Jérome

• Publication date : 30 April 2019 More

  Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

  J Pathol.

  Authors : Cindy Neuzillet Annemilaï Tijeras-Raballand Chanthirika Ragulan Cros Jérome Yatish Patil Matthieu Martinet Mert Erkan Jörg Kleeff Jeremy Wilson Minoti Apte Marie Tosolini Abigail S Wilson Francesca R Delvecchio Corinne Bousquet Paradis Valérie Hammel Pascal Anguraj Sadanandam Hemant M Kocher

• Publication date : 31 March 2019 More

  Endothelial fatty liver binding protein 4: a new targetable mediator in hepatocellular carcinoma related to metabolic syndrome.

  Oncogene.

  Authors : Laouirem Samira Sannier A Norkowski E Cauchy F Doblas Sabrina Rautou Pierre-Emmanuel Albuquerque Miguel Garteiser Philippe Sognigbé L Raffenne Jérome Van Beers Bernard Soubrane Olivier Bedossa Pierre Cros Jérome Paradis Valérie

• Publication date : 20 January 2019 More

  Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset

  Cancers (Basel).

  Authors : Nicolle Rémy Raffenne Jérome Paradis Valérie Couvelard Anne Aurelien de Reynies Yuna Blum Cros Jérome

• Publication date : 31 December 2018 More

  Proteomic Landscape of Cholangiocarcinomas Reveals Three Different Subgroups According to Their Localization and the Aspect of Non-Tumor Liver.

  Proteomics Clin Appl.

  Authors : Le Faouder Julie Gigante E Léger T Albuquerque Miguel Beaufrère A Soubrane Olivier Dokmak S Camadro JM Cros Jérome Paradis Valérie

• Publication date : 01 October 2018 More

  Obesity-induced pancreatopathy in rats is reversible after bariatric surgery

  Sci Rep

  Authors : Rebours Vinciane Garteiser Philippe Ribeiro-Parenti Lara Cavin JB Doblas Sabrina Page Gwenael Bado André Couvineau Alain Ruszniewski Philippe Paradis Valérie Le Gall Maude Van Beers Bernard Couvelard Anne

• Publication date : 30 September 2018 More

  Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis.

  Hepatology

  Authors : Payancé A Silva-Junior G Bissonnette J Tanguy Marion Pasquet B Levi C Roux O Nekachtali O Baiges A Hernández-Gea V Laouénan C Lebrec D Albuquerque Miguel Paradis Valérie Moreau Richard Valla Dominique Durand François Boulanger CM Garcia-Pagan JC Rautou Pierre-Emmanuel

• Publication date : 30 June 2018 More

  Recurrent attacks of acute hepatic porphyria: major role of the chronic inflammatory response in the liver.

  J Intern Med.

  Authors : Martin-Schmitt Caroline Lenglet H Yu A Delaby C Benecke A Lefebvre Thibaud Letteron Philippe Paradis Valérie Wahlin S Sandberg S Harper P Sardh E Sandvik AK Hov JR Aarsand AK Chiche L Bazille C Scoazec JY To-Figueras J Carrascal M Abian J Mirmiran Arienne Deybach Jean-Charles Puy Hervé Peoch'h Katell Manceau Hana Gouya Laurent

• Publication date : 31 May 2018 More

  Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

  Nat Commun.

  Authors : Hegde P Weiss Emmanuel Paradis Valérie Wan Jinghong Mabire Morgane Sukriti S Rautou Pierre-Emmanuel Albuquerque Miguel Picq O Gupta AC Ferrere G Gilgenkrantz Hélène Kiaf B Toubal A Beaudoin L Letteron Philippe Moreau Richard Lehuen A Lotersztajn Sophie

• Publication date : 31 March 2018 More

  Contribution of virtual biopsy to the screening of microvascular invasion in hepatocellular carcinoma: A pilot study

  Liver Int.

  Authors : Poté Nicolas Cauchy François Albuquerque Miguel Cros Jérome Soubrane Olivier Bedossa Pierre Paradis Valérie

• Publication date : 08 January 2018 More

  In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma.

  Oncotarget.

  Authors : Dayot Stephanie Speisky D Couvelard Anne Bourgoin P Gratio Valérie Cros Jérome Rebours Vinciane Sauvanet Alain Bedossa Pierre Paradis Valérie Ruszniewski Philippe Couvineau Alain Voisin Thierry

• Publication date : 27 April 2017 More

  Hepatic Fibrosis, Inflammation, and Steatosis: Influence on the MR Viscoelastic and Diffusion Parameters in Patients with Chronic Liver Disease

  Radiology

  Authors : Leitão HS Doblas Sabrina Garteiser Philippe d'Assignies G Paradis Valérie Mouri F Geraldes CF Ronot Maxime Van Beers Bernard

• Publication date : 14 November 2016 More

  Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression

  Gut. 2016 Nov;65(11):1882-1894

  Authors : Loyer X Paradis Valérie Hénique C Vion AC Colnot N Guerin CL Devue C On S Scetbun J Romain M Paul JL Rothenberg ME Marcellin Patrick Durand François Bedossa Pierre Prip-Buus C Baugé E Staels B Boulanger CM Tedgui A Rautou Pierre-Emmanuel

• Publication date : 31 July 2016 More

  Hepatic fat fraction and visceral adipose tissue fatty acid composition in mice: Quantification with 7.0T MRI

  Magn Reson Med

  Authors : Leporq B Lambert SA Ronot Maxime Boucenna I Colinart P Cauchy F Vilgrain Valérie Paradis Valérie Van Beers Bernard

• Publication date : 31 January 2015 More

  Advanced fibrosis: correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver

  Radiology

  Authors : Lagadec M Doblas Sabrina Giraudeau C Ronot Maxime Lambert SA Fasseu M Paradis Valérie Moreau Richard Pastor CM Vilgrain Valérie Daire Jean-Luc Van Beers Bernard

• Publication date : 09 April 2014 More

  Viscoelastic parameters for quantifying liver fibrosis: three-dimensional multifrequency MR elastography study on thin liver rat slices

  PLOS One, 2014;9(4):e94679

  Authors : Ronot Maxime Lambert SA Wagner M Garteiser Philippe Doblas Sabrina Albuquerque Miguel Paradis Valérie Vilgrain Valérie Sinkus R Van Beers Bernard

• Publication date : 29 September 2013 More

  Hypoxia pathways and cellular stress activate pancreatic stellate cells: development of an organotypic culture model of thick slices of normal human pancreas

  PLoS One, 2013;8:e76229

  Authors : Rebours Vinciane Albuquerque Miguel Sauvanet Alain Ruszniewski Philippe Levy Philippe Paradis Valérie Bedossa Pierre Couvelard Anne

• Publication date : 29 July 2013 More

  Imaging mass spectrometry reveals modified forms of histone H4 as new biomarkers of microvascular invasion in hepatocellular carcinomas

  Hepatology, 2013;58:983-94

  Authors : Poté Nicolas Alexandrov T Le Faouder Julie Laouirem Samira Léger T Mebarki M Belghiti Jacques Camadro JM Bedossa Pierre Paradis Valérie

• Publication date : 31 August 2012 More

  Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome

  Gut, 2013;62:911-9.

  Authors : Paradis Valérie Albuquerque Miguel Mebarki M Hernandez L Zalinski S Quentin S Belghiti Jacques Soulier J Bedossa Pierre

• Publication date : 31 July 2012 More

  Diffusion-weighted MR imaging for the regional characterization of liver tumors

  Radiology, 2012;264(2):464-472

  Authors : Wagner Mathilde Doblas Sabrina Daire Jean-Luc Paradis Valérie Haddad Nathalie Leitão Helena Garteiser Philippe Vilgrain Valérie Sinkus Ralph Van Beers Bernard

• Publication date : 29 March 2012 More

  Abnormal Plasma Microparticles Impair Vasoconstrictor Responses in Patients with Cirrhosis.

  Gastroenterology.

  Authors : Rautou Pierre-Emmanuel Bresson J Sainte-Marie Y Vion AC Paradis Valérie Renard JM Devue C Heymes C Letteron Philippe Elkrief Laure Lebrec D Valla Dominique Tedgui A Moreau Richard Boulanger CM

• Publication date : 30 April 2011 More

  Aberrant expression of OX1 receptors for orexins in colon cancers and liver metastases: an openable gate to apoptosis

  Cancer Res

  Authors : Voisin Thierry El Firar A Fasseu M Rouyer-Fessard C Descatoire V Walker Francine Paradis Valérie Bedossa Pierre Henin D Lehy T Laburthe M