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Translational Genomics of pancreatic Neoplasia Heterogeneity (GeNeHetX)
Team Nicolle
Scientific axes : Oncogenic inflammation & tumor development axis
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Team Leader(s)
Researcher(s)
Presentation
GeNeHetX is an ATIP-AVENIR team (class of 2022) whose objective is to characterize the inter and intra patient heterogeneity of pancreatic tumors. The work of the team is focused on two main axes. The first one aims at describing the histological and molecular heterogeneity at work in pancreatic adenocarcinomas. These particularly fibrous and aggressive tumors form a tissue with a complex architecture. The use of tools resulting from recent developments in the field of artificial intelligence combined with spatialized molecular profiling methods allows us to understand the organization of these complex tissues and to decipher the role of each cell type. This first axis of modeling morpho-molecular heterogeneity is fundamental for the other objective of the team which is to develop clinical tools, and in particular molecular signatures, for clinical decision support. This translational aspect of the research aims at transferring phenotypic description tools (RNA theranostic signatures in particular) for personalized medicine.
Landmark publications
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Publication date : 04 January 2022 More
PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides
BioRXiv
Authors : C. Saillard F. Delecourt B. Schmauch O. Moindrot M. Svrcek A. Bardier-Dupas J-F. Emile M. Ayadi V. Rebours L. de Mestier P. Hammel C. Neuzillet J-B. Bachet J. Iovanna N. Dusetti Y. Blum M. Richard Y. Kermezli Paradis Valérie M. Zaslavskiy P. Courtiol A. Kamoun Nicolle Rémy Cros Jérome
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Publication date : 17 March 2021 More
Tumour and stroma RNA signatures predict more accurately distant recurrence than clinicopathological factors in resected pancreatic adenocarcinoma
Eur J Cancer .
Authors : Hilmi Marc Cros Jérome Francesco Puleo Jeremy Augustin Jean-Francois Emile Magali Svrcek Hammel Pascal Tatjana Arsenijevic Jean-Luc Van Laethem Jean-Baptiste Bachet Nicolle Rémy
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Publication date : 10 November 2020 More
A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma
Annals of Oncology.
Authors : Nicolle Rémy O. Gayet P. Duconseil C. Vanbrugghe J. Roques M. Bigonnet Y. Blum N. Elarouci L. Armenoult M. Ayadi A. de Reyniès F. Puleo J. Augustin J.F. Emile M. Svrcek T. Arsenijevic P. Hammel M. Giovannini P. Grandval L. Dahan V. Moutardier M. Gilabert J.L. Van Laethem J.B. Bachet Cros Jérome J. Iovanna N.J. Dusetti
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Publication date : 02 July 2020 More
Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer
EBioMedicine.
Authors : Nicolle Rémy Yuna Blum Pauline Duconseil Charles Vanbrugghe Nicolas Brandone Flora Poizat Julie Roques Martin Bigonnet Odile Gayet Marion Rubis Nabila Elarouci Lucile Armenoult Mira Ayadi Aurélien de Reyniès Marc Giovannini Philippe Grandval Stephane Garcia Cindy Canivet Cros Jérome Barbara Bournet Louis Buscail BACAP Consortium Vincent Moutardier Marine Gilabert Juan Iovanna Nelson Dusetti