Team composition
The team’s project is to understand the mechanisms involved in the development of renal fibrosis, in particular as a consequence of the deposition of monoclonal immunoglobulins. Indeed, some rare diseases, grouped under the term monoclonal gammopathies of renal significance, are the consequence of the deposition of monoclonal immunoglobulins in the kidney. These Ig are secreted by a B clone, generally non-cancerous, but the damage to organs can be dramatic, causing renal failure for example.
In our team, funded by the Fondation Recherche Médicale (FRM), we are particularly interested in the role of senescence in Randall-type monoclonal immunoglobulin depot disease (MIDD). The aim of this project is to gain a better understanding of the mechanisms of organ damage downstream of monoclonal Ig. In the longer term, since the lesions observed in MIDD mimic those of diabetic nephropathy, we will assess whether the mechanisms identified in MIDD could provide a better understanding of the development of lesions in diabetic nephropathy.