The scientific focus on “Pathophysiology of Inflammatory & Fibrotic Diseases” aims to decipher the inflammatory and fibrosing mechanisms underlying chronic diseases affecting various organs, including the lungs, liver, kidneys, and intestines. Inflammation and fibrosis are major physiological and/or pathological responses involved in many chronic diseases. A thorough understanding of these mechanisms is therefore essential for identifying new therapeutic targets.
Our work focuses on identifying the common characteristics of inflammatory mechanisms within immune, endothelial, epithelial, and fibroblastic cells, highlighting the cellular and molecular interactions that contribute to disease progression. By exploring these processes in contexts as varied as viral hepatitis, inflammatory and fibrosing lung diseases, gastrointestinal disorders, and cancers, we aim to develop innovative approaches to modulate inflammation and limit fibrosis.
This research area benefits from the multidisciplinary expertise of all its research teams, each bringing a complementary perspective to the study of these diseases. Our researchers combine fundamental, translational, and clinical approaches to better understand the mechanisms involved and thus advance knowledge. Our goal is to propose therapeutic strategies tailored to the specific characteristics of each organ and improve the management of patients with these chronic conditions.
