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The Nephrology, Immunology and Hematology (NIH) department comprises five teams (ApreT, BMI, GLOMI, HIROS, PNI). Our research focuses on the study of inflammatory mechanisms involved in the development of chronic inflammatory and autoimmune diseases.
The diseases studied in the NIH department include kidney diseases, various inflammatory diseases of immune origin (lupus, arthritis, allergies, infections, etc.), hematological diseases (hemochromatosis, iron deficiency disorders), and certain cancers.
Our general objectives are to study the infiltrating or resident cellular players (basophils, mast cells, phagocytes, lymphocytes, dendritic cells, etc.), the cellular and molecular mechanisms (genetic factors, receptors, trafficking, signaling), as well as the role of inflammatory mediators and humoral factors that participate in the initiation, progression, or resolution of the processes involved in these diseases.
The close interaction between the NIH department teams and clinicians The Paris North University Hospitals also allows us to integrate our projects with strong translational research. Our work also aims to develop therapeutic approaches, particularly in collaboration with partner start-ups (Inatherys).
Our research teams actively participate in several national and international research networks (EMBRN; EPNET) and are involved in various Investments for the Future programs: Labex (Laboratories of Excellence), Inflamex, GR-Ex, and DHU (University Hospital Department) FIRE.
The NIH department is involved in a specific joint Master 1 and 2 program between the University of Paris and Paris 13 Sorbonne Paris Nord University on inflammation and inflammatory diseases (IMI Master) and welcomes students into its teams for their practical internships.
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The NIH department comprises seven teams, including two ATIP/Avenir teams.
Our research focuses on the study of inflammatory mechanisms involved in kidney diseases, inflammatory diseases of immune origin (lupus, arthritis, infections, GVHD), or hematological origin (heme and iron).
Our research focuses on the study of inflammatory mechanisms involved in kidney diseases, inflammatory diseases of immune origin (lupus, arthritis, infections, GVHD), or hematological origin (heme and iron).
The main research areas developed concern:
We study cellular and molecular mechanisms (genetic factors, receptors and signaling, etc.), and cellular actors (tissue and immunological cells), with a particular focus on those of the innate immune response and the role of inflammatory mediators and released humoral factors.
Our research teams actively participate in several national and international research networks (EMBRN, www.embrn.eu; IIGANN, www.iigann.com; EPNET, www.porphyria-europe.com) and are involved in various Investments for the Future programs (Inflamex, www.inflamex.fr; GR-Ex, http://www.labex-grex.com) and the university hospital department. (DHU FIRE, www.dhufire.org).
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