⚠️ This content is not available in English.

Authors

Ribeiro-Parenti Lara,
[:en]Anne-Charlotte Jarry[:],
[:en]Jean-Baptiste Cavin[:],
Willemetz Alexandra,
Le Beyec Le Bihan Johanne,
[:en]Aurélie Sannier[:],
Benadda Samira,
Pelletier Anne-Laure,
[:en]Muriel Hourseau[:],
[:en]Thibaut Léger[:],
[:en]Bastien Morlet[:],
Couvelard Anne,
[:en]Younes Anini[:],
Msika Simon,
Marmuse Jean-Pierre,
Ledoux Séverine,
Le Gall Maude,
Bado André,

[:en]

Abstract

Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.

[:]

Other publications

Analysis of the Efficacy and the Long-term Metabolic and Nutritional Status of Sleeve Gastrectomy with Transit Bipartition Compared to Roux-en-Y Gastric Bypass in Obese Rats

Obes Surg.
01 Feb 2023
Authors :
Baratte Clément,
Willemetz Alexandra,
Ribeiro-Parenti Lara,
Claire Carette,
Msika Simon,
Bado André,
Sebastien Czernichow,
Le Gall Maude,
Poghosyan Tigran,
Find out more

Shortening the Biliopancreatic Limb Length of One Anastomosis Gastric Bypass Maintains Glucose Homeostasis Improvement with Limited Weight Loss

J Clin Med.
30 Aug 2022
Authors :
Ribeiro-Parenti Lara,
Hounayda El Jindi,
Willemetz Alexandra,
Matthieu Siebert,
Nathalie Kapel,
Le Beyec Le Bihan Johanne,
Bado André,
Le Gall Maude,
Find out more

Similar Gut Hormone Secretions Two Years After One Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass: a Pilot Study.

Obes Surg.
06 Jan 2022
Authors :
[:fr]David De Bandt[:],
[:fr]Claire Rives-Lange[:],
[:fr]Yvann Frigout[:],
[:fr]Damien Bergerot[:],
[:fr]Anne Blanchard[:],
Le Gall Maude,
[:fr]Jean-Marc Lacorte[:],
[:fr]Jean-Marc Chevallier[:],
[:fr]Sébastien Czernichow[:],
Poghosyan Tigran,
[:fr]Claire Carette[:],
Le Beyec Le Bihan Johanne,
Find out more

Prevention and treatment of nutritional complications after bariatric surgery

Lancet Gastroenterol Hepatol.
28 Feb 2021
Authors :
[:fr]Alexandre Nuzzo[:],
[:fr]Sebastien Czernichow[:],
[:fr]Alexandre Hertig[:],
Ledoux Séverine,
Poghosyan Tigran,
[:fr]Didier Quilliot[:],
Le Gall Maude,
Bado André,
Joly Francisca,
Find out more