Publications

• Publication date : 23 April 2025 More

  Defective autophagy in CD4 T cells drives liver fibrosis via type 3 inflammation

  Nature Communications

  Authors : Al Sayegh Rola Wan Jinghong Caër Charles Azoulai Margot Maxime Gasperment Sukriti Baweja Marc-Anthony Chouillard Kandiah Janany Cadoux Mathilde Mabire Morgane Pignolet Camille Tristan Thibault-Sogorb Hammoutene Adel Paradis Valérie Saveanu Loredana Nicolle Rémy Gilgenkrantz Hélène Weiss Emmanuel Lotersztajn Sophie

• Publication date : 09 April 2025 More

  Protective role of oleic acid against palmitic acid-induced pancreatic fibrosis

  J Transl Med.

  Authors : Frendi Sonia Anaïs Chassac Véron Killian Raffenne Jérome Nicolle Rémy Albuquerque Miguel Paradis Valérie Couvelard Anne Cros Jérome Rebours Vinciane

• Publication date : 10 February 2025 More

  Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach

  J Pathol.

  Authors : Hilmi Marc Flore Delecourt Raffenne Jérome Bourega Taib Nelson Dusetti Juan Iovanna Yuna Blum Magali Richard Cindy Neuzillet Couvelard Anne Matthieu Tihy De Mestier Louis Rebours Vinciane Nicolle Rémy Cros Jérome

• Publication date : 03 October 2024 More

  The genomic and transcriptomic landscape of metastastic urothelial cancer

  Nat Commun.

  Authors : Yohann Loriot Maud Kamal Laurene Syx Nicolle Rémy Celia Dupain Naoual Mensourri Igor Duquesne Pernelle Lavaud Claudio Nicotra Maud Ngocamus Ludovic Lacroix Lambros Tselikas Gilles Crehange Luc Friboulet Zahra Castel-Ajgal Yann Neuzillet Edith Borcoman Philippe Beuzeboc Grégoire Marret Tom Gutman Jennifer Wong Francois Radvanyi Sylvain Dureau Jean-Yves Scoazec Nicolas Servant Yves Allory Benjamin Besse Fabrice Andre Christophe Le Tourneau Christophe Massard Ivan Bieche

• Publication date : 05 September 2024 More

  Prognostic impact of the tumour microenvironment in intrahepatic cholangiocarcinoma: identification of a peritumoural fibro-immune interface

  Virchows Arch.

  Authors : Gwladys Lubuela Beaufrère Aurélie Albuquerque Miguel Camille Pignollet Nicolle Rémy Lesurtel Mickaël Bouattour Mohamed Cros Jérome Paradis Valérie

• Publication date : 18 March 2024 More

  Role of the fatty pancreatic infiltration in pancreatic oncogenesis

  Sci Rep.

  Authors : Frendi Sonia Chloé Martineau Cazier Hélène Nicolle Rémy Anaïs Chassac Albuquerque Miguel Raffenne Jérome Le Faouder Julie Paradis Valérie Cros Jérome Couvelard Anne Rebours Vinciane

• Publication date : 30 November 2023 More

  The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy

  Lancet Gastroenterol Hepatol.

  Authors : Hilmi Marc Matthieu Delaye Milena Muzzolini Nicolle Rémy Cros Jérome Hammel Pascal Victoire Cardot-Ruffino Cindy Neuzillet

• Publication date : 13 November 2023 More

  Prediction of Adjuvant Gemcitabine Sensitivity in Resectable Pancreatic Adenocarcinoma Using the GemPred RNA Signature: An Ancillary Study of the PRODIGE-24/CCTG PA6 Clinical Trial

  J Clin Oncol.

  Authors : Nicolle Rémy Jean-Baptiste Bachet Alexandre Harlé Juan Iovanna Hammel Pascal Rebours Vinciane Anthony Turpin Meher Ben Abdelghani Alice Wei Emmanuel Mitry Anthony Lopez James Biagi Eric François Pascal Artru Aurélien Lambert Daniel J Renouf Laure Monard Marjorie Mauduit Nelson Dusetti Thierry Conroy Cros Jérome

• Publication date : 12 June 2023 More

  Pacpaint: a histology-based deep learning model uncovers the extensive intratumor molecular heterogeneity of pancreatic adenocarcinoma

  Nat Commun.

  Authors : Charlie Saillard Flore Delecourt Benoit Schmauch Olivier Moindrot Magali Svrcek Armelle Bardier-Dupas Jean Francois Emile Mira Ayadi Rebours Vinciane De Mestier Louis Hammel Pascal Cindy Neuzillet Jean Baptiste Bachet Juan Iovanna Nelson Dusetti Yuna Blum Magali Richard Yasmina Kermezli Paradis Valérie Mikhail Zaslavskiy Pierre Courtiol Aurelie Kamoun Nicolle Rémy Cros Jérome

• Publication date : 31 August 2022 More

  Molecular deciphering of primary liver neuroendocrine neoplasms confirms their distinct existence with foregut-like profile

  J Pathol.

  Authors : De Mestier Louis Nicolle Rémy Poté Nicolas Rebours Vinciane Cauchy François Olivia Hentic Frédérique Maire Ronot Maxime Lebtahi Rachida Sauvanet Alain Paradis Valérie Ruszniewski Philippe Couvelard Anne Cros Jérome

• Publication date : 04 January 2022 More

  PACpAInt: a deep learning approach to identify molecular subtypes of pancreatic adenocarcinoma on histology slides

  BioRXiv

  Authors : C. Saillard F. Delecourt B. Schmauch O. Moindrot M. Svrcek A. Bardier-Dupas J-F. Emile M. Ayadi V. Rebours L. de Mestier P. Hammel C. Neuzillet J-B. Bachet J. Iovanna N. Dusetti Y. Blum M. Richard Y. Kermezli Paradis Valérie M. Zaslavskiy P. Courtiol A. Kamoun Nicolle Rémy Cros Jérome

• Publication date : 17 March 2021 More

  Tumour and stroma RNA signatures predict more accurately distant recurrence than clinicopathological factors in resected pancreatic adenocarcinoma

  Eur J Cancer .

  Authors : Hilmi Marc Cros Jérome Francesco Puleo Jeremy Augustin Jean-Francois Emile Magali Svrcek Hammel Pascal Tatjana Arsenijevic Jean-Luc Van Laethem Jean-Baptiste Bachet Nicolle Rémy

• Publication date : 10 November 2020 More

  A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma

  Annals of Oncology.

  Authors : Nicolle Rémy O. Gayet P. Duconseil C. Vanbrugghe J. Roques M. Bigonnet Y. Blum N. Elarouci L. Armenoult M. Ayadi A. de Reyniès F. Puleo J. Augustin J.F. Emile M. Svrcek T. Arsenijevic P. Hammel M. Giovannini P. Grandval L. Dahan V. Moutardier M. Gilabert J.L. Van Laethem J.B. Bachet Cros Jérome J. Iovanna N.J. Dusetti

• Publication date : 02 July 2020 More

  Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

  EBioMedicine.

  Authors : Nicolle Rémy Yuna Blum Pauline Duconseil Charles Vanbrugghe Nicolas Brandone Flora Poizat Julie Roques Martin Bigonnet Odile Gayet Marion Rubis Nabila Elarouci Lucile Armenoult Mira Ayadi Aurélien de Reyniès Marc Giovannini Philippe Grandval Stephane Garcia Cindy Canivet Cros Jérome Barbara Bournet Louis Buscail BACAP Consortium Vincent Moutardier Marine Gilabert Juan Iovanna Nelson Dusetti

• Publication date : 20 January 2019 More

  Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset

  Cancers (Basel).

  Authors : Nicolle Rémy Raffenne Jérome Paradis Valérie Couvelard Anne Aurelien de Reynies Yuna Blum Cros Jérome