Publications

• Publication date : 23 April 2025 More

  Defective autophagy in CD4 T cells drives liver fibrosis via type 3 inflammation

  Nature Communications

  Authors : Al Sayegh Rola Wan Jinghong Caër Charles Azoulai Margot Maxime Gasperment Sukriti Baweja Marc-Anthony Chouillard Kandiah Janany Cadoux Mathilde Mabire Morgane Pignolet Camille Tristan Thibault-Sogorb Hammoutene Adel Paradis Valérie Saveanu Loredana Nicolle Rémy Gilgenkrantz Hélène Weiss Emmanuel Lotersztajn Sophie

• Publication date : 11 July 2023 More

  A new NRF2 activator for the treatment of human metabolic dysfunction-associated fatty liver disease

  JHEP Rep.

  Authors : Hammoutene Adel Laouirem Samira Albuquerque Miguel Nathalie Colnot Brzustowski Angelique Valla Dominique Nicolas Provost Philippe Delerive Paradis Valérie QUID-NASH Research Group

• Publication date : 08 June 2023 More

  Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis

  J Hepatol

  Authors : Elkrief Laure Nathalie Ganne-Carrié Manceau Hana Tanguy Marion Shantha Ram Valainathan Alix Riescher-Tuczkiewicz Biquard Louise Nathalie Barget Cendrine Chaffaut Alexandre Louvet Paradis Valérie Marianne Ziol Rikke Bæk Malene Møller Jørgensen Guillaume Van Niel Pierre-Michael Coly Hammoutene Adel Fanny Dujardin Katell Peoc'h Thierry Poynard Sylvie Chevret Rautou Pierre-Emmanuel CIRRAL group

• Publication date : 15 May 2023 More

  Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

  JHEP Rep.

  Authors : Allaire Manon Al Sayegh Rola Mabire Morgane Hammoutene Adel Matthieu Siebert Caër Charles Cadoux Mathilde Wan Jinghong Habib Aida Le Gall Maude Pierre de la Grange Hervé Guillou Catherine Postic Paradis Valérie Lotersztajn Sophie Gilgenkrantz Hélène

• Publication date : 31 March 2023 More

  MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

  Nature Commun.

  Authors : Mabire Morgane Pushpa Hegde Hammoutene Adel Wan Jinghong Caër Charles Al Sayegh Rola Cadoux Mathilde Weiss Emmanuel Tristan Thibault-Sogorb Olivier Lantz Michèle Goodhardt Paradis Valérie Pierre de la Grange Gilgenkrantz Hélène Lotersztajn Sophie

• Publication date : 15 December 2022 More

  Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice

  JHep Reports

  Authors : Klaus Seedorf Csaba Weber Cedric Vinson Sylvie Berger Laurent-Michel Vuillard Arpad Kiss Stephanie Creusot Olivier Broux Anne Geant Catherine Ilic Karine Lemaitre Johann Richard Hammoutene Adel Julien Mahieux Virginie Martigny Didier Durand Fabien Melchiore Miklos Nyerges Paradis Valérie Nicolas Provost Valérie Duvivier Philippe Delerive

• Publication date : 24 July 2022 More

  Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

  Dev Cell.

  Authors : Romain Donne Maëva Saroul-Ainama Pierre Cordier Hammoutene Adel Christelle Kabore Mira Stadler Ivan Nemazanyy Isabelle Galy-Fauroux Mounia Herrag Tobias Riedl Marie Chansel-Da Cruz Stefano Caruso Stéphanie Bonnafous Rupert Öllinger Roland Rad Kristian Unger Albert Tran Jean-Pierre Couty Philippe Gual Paradis Valérie Séverine Celton-Morizur Mathias Heikenwalder Patrick Revy Chantal Desdouets

• Publication date : 30 March 2022 More

  Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs

  J Clin Exp Hepatol.

  Authors : Valérie Duvivier Stéphanie Creusot Olivier Broux Aurélie Helbert Ludovic Lesage Kevin Moreau Nicolas Lesueur Lindsay Gerard Karine Lemaitre Nicolas Provost Edwige-Ludiwyne Hubert Tania Baltauss Nathalie De Preville Julia Geronimi Lucie Adoux Franck Letourneur Hammoutene Adel Valla Dominique Paradis Valérie Philippe Delerive

• Publication date : 10 February 2022 More

  Procollagen C-Proteinase Enhancer-1 (PCPE-1) deficiency in mice reduces liver fibrosis but not NASH progression

  PLoS One.

  Authors : Patricia Sansilvestri Morel Valerie Duvivier Florence Bertin Nicolas Provost Hammoutene Adel Edwige-Ludiwyne Hubert Arantxa Gonzalez Isabelle Tupinon-Mathieu Paradis Valérie Philippe Delerive

• Publication date : 29 February 2020 More

  A defect in endothelial autophagy occurs in patients with non-alcoholic steatohepatitis and promotes inflammation and fibrosis

  J Hepatol.

  Authors : Hammoutene Adel Biquard Louise Juliette Lasselin Marouane Kheloufi Tanguy Marion Anne-Clémence Vion Jules Mérian Nathalie Colnot Xavier Loyer Alain Tedgui Patrice Codogno Lotersztajn Sophie Paradis Valérie Chantal M Boulanger Rautou Pierre-Emmanuel

• Publication date : 31 May 2019 More

  Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease.

  J Hepatol.

  Authors : Hammoutene Adel Rautou Pierre-Emmanuel

• Publication date : 09 October 2017 More

  Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

  Proc Natl Acad Sci U S A, 114(41):E8675-E8684

  Authors : Vion AC Kheloufi M Hammoutene Adel Poisson Johanne Lasselin J Devue C Pic I Dupont N Busse J Starke K Lafaurie-Janvore J Barakatf AI Loyer X Souyri M Viollet B Julia P Tedgui A Codogno P Boulanger CM Rautou Pierre-Emmanuel