Publications

• Publication date : 03 October 2025 More

  Silybum marianum seeds mitigate pro-inflammatory functions of human neutrophils and alleviate ulcerative colitis in rats

  Inflammopharmacology.

  Authors : Kouki Ahmed Riadh Marrouchi Abdelaziz Souli Salwa Bouabdallah Ferjani Wafa Dang Pham My-Chan Amadou Dicko El Benna Jamel Mossadok Ben-Attia

• Publication date : 24 July 2025 More

  Deciphering opsonized zymosan-induced phosphorylation of p47phox and NADPH oxidase activation in human neutrophils

  Blood.

  Authors : Liu Jie Pintard Coralie Thieblemont Nathalie Dang Pham My-Chan El Benna Jamel

• Publication date : 15 February 2025 More

  The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis

  Free Radic Biol Med.

  Authors : Anaïs Gardette Viviana Marzaioli Bedouhene Samia Gilles Hayem Hurtado-Nedelec Maria Margarita Yantao He Dang Pham My-Chan Dieude Philippe Zhong-Yin Zhang Marie Jean-Claude El Benna Jamel

• Publication date : 08 October 2024 More

  A new role for PI3Kγ in Fc receptor mediated cross-presentation

  Adv Sci (Weinh).

  Authors : Koumantou Despoina Aimé Cézaire Adiko Bourdely Pierre Nugue Mathilde Boedec Erwan El Benna Jamel Monteiro Renato Cosmin Saveanu Muriel Laffargue Matthias P Wymann Marc Dalod Guermonprez Pierre Saveanu Loredana

• Publication date : 08 October 2024 More

  Specific Requirement of the p84/p110γ Complex of PI3Kγ for Antibody‐Activated, Inducible Cross‐Presentation in Murine Type 2 DCs

  Adv Sci (Weinh).

  Authors : Koumantou Despoina Aimé Cézaire Adiko Bourdely Pierre Nugue Mathilde Boedec Erwan El Benna Jamel Monteiro Renato Cosmin Saveanu Muriel Laffargue Matthias P Wymann Marc Dalod Guermonprez Pierre Saveanu Loredana

• Publication date : 04 October 2024 More

  Opuntia ficus-indica cladodes extract inhibits human neutrophil pro-inflammatory functions and protects rats from acetic acid-induced ulcerative colitis

  Inflammopharmacology.

  Authors : Wafa Ferjani Ahmed Kouki Dang Pham My-Chan Hamadi Fetoui Yassine Chtourou Néziha Ghanem-Boughanmi Mossadok Ben-Attia El Benna Jamel Abdelaziz Souli

• Publication date : 06 June 2024 More

  The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites

  Int Immunopharmacol.

  Authors : Tarek Boussetta Houssam Raad Bedouhene Samia Arabi-Derkawi Riad Gougerot-Pocidalo Marie-Anne Gilles Hayem Dang Pham My-Chan El Benna Jamel

• Publication date : 01 April 2024 More

  BTK drives neutrophil activation for sterilizing antifungal immunity

  J Clin Invest.

  Authors : Jigar V Desai Marissa A Zarakas Andrew L Wishart Mark Roschewski Mariano A Aufiero Ágnes Donkó Gustaf Wigerblad Neta Shlezinger Markus Plate Matthew R James Jean K Lim Gulbu Uzel Jenna Re Bergerson Ivan Fuss Robert A Cramer Luis M Franco Emily S Clark Wasif N Khan Daisuke Yamanaka Georgios Chamilos El Benna Jamel Mariana J Kaplan Louis M Staudt Thomas L Leto Steven M Holland Wyndham H Wilson Tobias M Hohl Michail S Lionakis

• Publication date : 19 September 2023 More

  TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes

  Redox Biol.

  Authors : Ben-Khemis Marwah Liu Dan Pintard Coralie Song Zhuoyao Hurtado-Nedelec Maria Margarita Marie Jean-Claude El Benna Jamel Dang Pham My-Chan

• Publication date : 31 May 2023 More

  CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival

  Gut.

  Authors : Camille Danne Chloé Michaudel Jurate Skerniskyte Julien Planchais Aurélie Magniez Allison Agus Marie-Laure Michel Bruno Lamas Gregory Da Costa Madeleine Spatz Cyriane Oeuvray Chloé Galbert Maxime Poirier Yazhou Wang Alexia Lapière Nathalie Rolhion Tatiana Ledent Cédric Pionneau Solenne Chardonnet Floriant Bellvert Edern Cahoreau Amandine Rocher Rafael Rose Arguello Carole Peyssonnaux Sabine Louis Mathias L Richard Philippe Langella El Benna Jamel Benoit Marteyn Harry Sokol

• Publication date : 31 March 2023 More

  Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

  Hepatology.

  Authors : Loureiro Dimitri Tout Issam Alex Narguet Stéphanie Bed Cheikh Mohamed Morgane Roinard Ahmad Sleiman Boyer Nathalie Pons-Kerjean Nathalie Castelnau Corinne Nathalie Giuly Dorothy Tonui Vassili Soumelis El Benna Jamel Patrick Soussan Moreau Richard Paradis Valérie Mansouri Abdellah Asselah Tarik

• Publication date : 16 January 2023 More

  ROCK2 interacts with p22phox to phosphorylate p47phox and to control NADPH oxidase activation in human monocytes

  PNAS

  Authors : Asma Tlili Pintard Coralie Hurtado-Nedelec Maria Margarita Liu Dan Viviana Marzaioli Thieblemont Nathalie Dang Pham My-Chan El Benna Jamel

• Publication date : 01 January 2022 More

  Impaired p47phox phosphorylation in neutrophils from p67phox-deficient chronic granulomatous disease patients

  Blood.

  Authors : Sahra Amel Belambri Viviana Marzailoli Hurtado-Nedelec Maria Margarita Pintard Coralie Shiyu Liang Yezhou Liu Tarek Boussetta Gougerot-Pocidalo Marie-Anne Richard D Ye Dang Pham My-Chan El Benna Jamel

• Publication date : 28 January 2022 More

  Metformin Inhibits ROS Production by Human M2 Macrophages via the Activation of AMPK

  Biomedicines

  Authors : Rana M Nassif Elias Chalhoub Pia Chedid Hurtado-Nedelec Maria Margarita Elia Raya Dang Pham My-Chan Marie Jean-Claude El Benna Jamel

• Publication date : 10 January 2022 More

  Protein Kinase CK2 acts as a molecular brake to control NADPH oxidase 1 activation and colon inflammation

  Cell Mol Gastroenterol Hepatol.

  Authors : Liu Dan Marie Jean-Claude Pelletier Anne-Laure Song Zhuoyao Ben-Khemis Marwah Kaouthar Boudiaf Pintard Coralie Thibaut Leger Samuel Terrier Guillaume Chevreux El Benna Jamel Dang Pham My-Chan

• Publication date : 05 September 2021 More

  Impaired respiratory burst contributes to infections in PKCδ-deficient patients

  J Exp Med.

  Authors : Anna-Lena Neehus Kunihiko Moriya Alejandro Nieto-Patlán Tom Le Voyer Romain Lévy Ahmet Özen Elif Karakoc-Aydiner Safa Baris Alisan Yildiran Engin Altundag Manon Roynard Kathrin Haake Mélanie Migaud Karim Dorgham Guy Gorochov Laurent Abel Nico Lachmann Figen Dogu Sule Haskologlu Erdal İnce El Benna Jamel Gulbu Uzel Ayca Kiykim Kaan Boztug Marion R Roderick Mohammad Shahrooei Paul A Brogan Hassan Abolhassani Gonca Hancioglu Nima Parvaneh Alexandre Belot Aydan Ikinciogullari Jean-Laurent Casanova Anne Puel Jacinta Bustamante

• Publication date : 31 August 2021 More

  Prolyl-Isomerase Pin1 Controls Key fMLP-Induced Neutrophil Functions

  Biomedicines

  Authors : Bedouhene Samia Liu Min Nassima Senani Tarek Boussetta Pintard Coralie Dang Pham My-Chan El Benna Jamel

• Publication date : 10 August 2021 More

  Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis

  Cell Host Microbe.

  Authors : Tonia Akoumianaki Katerina Vaporidi Eleni Diamantaki Frédéric Pène Remi Beau Mark S Gresnigt Marina Gkountzinopulou Maria Venichaki Elias Drakos El Benna Jamel George Samonis Kieu T T Le Vinod Kumar Dimitrios Georgopoulos Frank L van de Veerdonk Mihai G Netea Jean-Paul Latge Georgios Chamilos

• Publication date : 02 August 2020 More

  The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils

  Free Radic Biol Med

  Authors : Houssam Raad Hussein Mouawia Hamad Hassan Mohamed El-Seblani Riad Arabi-Derkawi Tarek Boussetta Gougerot-Pocidalo Marie-Anne Dang Pham My-Chan El Benna Jamel

• Publication date : 30 June 2020 More

  Apocynin prevents GM-CSF-induced-ERK1/2 activation and -neutrophil survival independently of its inhibitory effect on the phagocyte NADPH oxidase NOX2

  Biochem Pharmacol.

  Authors : Pintard Coralie Ben-Khemis Marwah Liu Dan Dang Pham My-Chan Hurtado-Nedelec Maria Margarita El Benna Jamel

• Publication date : 21 January 2020 More

  The dual role of ROS-generating NADPH oxidases in gastrointestinal inflammation and therapeutic perspectives.

  Antioxidants & Redox Signaling.

  Authors : Dang Pham My-Chan Rolas L El Benna Jamel

• Publication date : 31 October 2019 More

  The prolyl isomerase Pin1 controls lipopolysaccharide-induced priming of NADPH oxidase in human neutrophils.

  Frontiers In Immunology.

  Authors : Liu Min Bedouhene Samia Hurtado-Nedelec Maria Margarita Pintard Coralie Dang Pham My-Chan Yu S El Benna Jamel

• Publication date : 05 September 2019 More

  Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils.

  J Exp Med.

  Authors : Ohayon D De Chiara A Dang Pham My-Chan Thieblemont N Chatfield S Marzaioli V Burgener SS Mocek J Candalh C Pintard Coralie Tacnet-Delorme P Renault G Lagoutte I Favier M Walker Francine Hurtado-Nedelec Maria Margarita Desplancq D Weiss Emmanuel Benarafa C Housset D Marie Jean-Claude Frachet P El Benna Jamel Witko-Sarsat V

• Publication date : 28 February 2019 More

  The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes.

  J Immunol.

  Authors : Arabi-Derkawi R O'Dowd Y Cheng N Rolas L Boussetta T Raad H Marzaioli V Pintard Coralie Fasseu M Kroviarski Y Belambri SA Dang Pham My-Chan Ye RD Gougerot-Pocidalo Marie-Anne El Benna Jamel

• Publication date : 01 September 2018 More

  NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions

  Mucosal Immunology.

  Authors : Makhezer N Ben-Khemis Marwah Liu Dan Khichane Y Marzaioli V Tlili A Mojallali Marjan Pintard Coralie Letteron Philippe Hurtado-Nedelec Maria Margarita El Benna Jamel Marie Jean-Claude Sannier A Pelletier Anne-Laure Dang Pham My-Chan

• Publication date : 08 July 2018 More

  NADPH oxidase depletion in neutrophils from patients with cirrhosis and restoration via toll-like receptor 7/8 activation

  Gut. 2018;67(8):1505-1516

  Authors : Rolas L Boussif A Weiss Emmanuel Letteron Philippe Haddad O El Benna Jamel Rautou Pierre-Emmanuel Moreau Richard Perianin Axel

• Publication date : 11 October 2017 More

  NOX5 and p22phox are 2 novel regulators of human monocytic differentiation into dendritic cells.

  Blood. 2017 Oct 12;130(15):1734-1745

  Authors : Marzaioli V Hurtado-Nedelec Maria Margarita Pintard Coralie Tlili A Marie Jean-Claude Monteiro RC Gougerot-Pocidalo Marie-Anne Dang Pham My-Chan El Benna Jamel

• Publication date : 28 February 2017 More

  Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47(phox) phosphorylation pathway in monocytes

  Mucosal Immunology, 2017 Mar;10(2):332-340

  Authors : Chedid P Boussetta T Dang Pham My-Chan Belambri SA Marzaioli V, Fasseau M Walker Francine Couvineau Alain El Benna Jamel Marie Jean-Claude

• Publication date : 13 August 2015 More

  Macrophage autophagy protects against liver fibrosis in mice.

  Autophagy. 2015;11(8):1280-92.

  Authors : Lodder J Denaës T Chobert MN Wan Jinghong El Benna Jamel Pawlotsky JM Lotersztajn Sophie Teixeira-Clerc F

• Publication date : 24 July 2014 More

  Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis

  J Clin Invest.

  Authors : Ben Mkaddem Sanae Hayem G Jönsson F Rossato E Boedec Erwan Boussetta T El Benna Jamel Launay Pierre Goujon JM Benhamou Marc Bruhns P Monteiro Renato

• Publication date : 28 February 2013 More

  Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis

  Hepatology.

  Authors : Loïc Rolas Nesrine Makhezer Soumeya Hadjoudj El Benna Jamel Bahia Djerdjouri Elkrief Laure Moreau Richard Perianin Axel

• Publication date : 30 June 2012 More

  Towards specific NADPH oxidase inhibition by small synthetic peptides

  Cell Mol Life Sci.

  Authors : El Benna Jamel Dang Pham My-Chan Perianin Axel

• Publication date : 22 December 2010 More

  The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils.

  Blood. 2010 Dec 23;116(26):5795-802

  Authors : Boussetta T Gougerot-Pocidalo Marie-Anne Hayem G Ciappelloni S Raad H Arabi Derkawi R Bournier O Kroviarski Y Zhou XZ Malter JS Lu PK Bartegi A Dang Pham My-Chan El Benna Jamel