Publications

• Publication date : 21 August 2025 More

  Non-canonical Gq activation by orexin receptor type 2 and lemborexant observed in microsecond molecular dynamics simulations

  Scientific Reports

  Authors : Paulina Dragan Gratio Valérie Voisin Thierry Couvineau Alain Dorota Latek

• Publication date : 31 March 2025 More

  Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two-sided nature of antagonistic ligands resulting from partial dissociation of Gq

  Br J Pharmacol.

  Authors : Gratio Valérie Paulina Dragan Garcia Laurine Saveanu Loredana Nicole Pascal Voisin Thierry Dorota Latek Couvineau Alain

• Publication date : 30 September 2024 More

  Orexins mitigate obesity-associated dysfunctions in mice

  Obesity (Silver Spring).

  Authors : Anne Blais Isabelle Denis Mireille Andriamihaja Gratio Valérie Gaelle Champeil-Potokar Laouirem Samira Anais Chassac Couvelard Anne Paradis Valérie Voisin Thierry Anne-Marie Davila Couvineau Alain

• Publication date : 27 November 2023 More

  Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

  Cytometry A.

  Authors : Gratio Valérie Dayot Stephanie Benadda Samira Nicole Pascal Saveanu Loredana Voisin Thierry Couvineau Alain

• Publication date : 27 November 2023 More

  Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

  Cytometry A.

  Authors : Gratio Valérie Dayot Stephanie Benadda Samira Nicole Pascal Saveanu Loredana Voisin Thierry Couvineau Alain

• Publication date : 11 June 2023 More

  Editorial: A year in review: discussions in molecular and structural endocrinology

  Front Endocrinol (Lausanne).

  Authors : Couvineau Alain Ernestina Marianna De Francesco

• Publication date : 30 May 2023 More

  Efficiency of Orexin-A for Inflammatory Flare and Mucosal Healing in Experimental Colitis: Comparison with the Anti-TNF Alpha Infliximab

  Int J Mol Sci.

  Authors : Anne Blais Annaïg Lan François Blachier Robert Benamouzig Pauline Jouet Couvineau Alain

• Publication date : 27 July 2022 More

  The Orexin receptors: Structural and anti-tumoral properties

  Front Endocrinol (Lausanne).

  Authors : Couvineau Alain Nicole Pascal Gratio Valérie Voisin Thierry

• Publication date : 06 June 2022 More

  The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment

  Frontiers on Oncology

  Authors : Voisin Thierry Nicole Pascal Gratio Valérie Anaïs Chassac Dounia Mansour Rebours Vinciane Couvelard Anne Couvineau Alain

• Publication date : 27 November 2021 More

  Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions

  World J Gastroenterol.

  Authors : Couvineau Alain Voisin Thierry Nicole Pascal Gratio Valérie Anne Blais

• Publication date : 01 October 2018 More

  Obesity-induced pancreatopathy in rats is reversible after bariatric surgery

  Sci Rep

  Authors : Rebours Vinciane Garteiser Philippe Ribeiro-Parenti Lara Cavin JB Doblas Sabrina Page Gwenael Bado André Couvineau Alain Ruszniewski Philippe Paradis Valérie Le Gall Maude Van Beers Bernard Couvelard Anne

• Publication date : 17 August 2018 More

  Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A.

  Biochim Biophys Acta Mol Basis Dis.

  Authors : Messal N Fernandez N Dayot Stephanie Gratio Valérie Nicole Pascal Prochasson C Chantret Isabelle LeGuilloux G Jarry A Couvelard Anne Treton Xavier Voisin Thierry Ogier-Denis Eric Couvineau Alain

• Publication date : 08 January 2018 More

  In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma.

  Oncotarget.

  Authors : Dayot Stephanie Speisky D Couvelard Anne Bourgoin P Gratio Valérie Cros Jérome Rebours Vinciane Sauvanet Alain Bedossa Pierre Paradis Valérie Ruszniewski Philippe Couvineau Alain Voisin Thierry

• Publication date : 28 February 2017 More

  Vasoactive intestinal peptide dampens formyl-peptide-induced ROS production and inflammation by targeting a MAPK-p47(phox) phosphorylation pathway in monocytes

  Mucosal Immunology, 2017 Mar;10(2):332-340

  Authors : Chedid P Boussetta T Dang Pham My-Chan Belambri SA Marzaioli V, Fasseau M Walker Francine Couvineau Alain El Benna Jamel Marie Jean-Claude

• Publication date : 03 May 2016 More

  Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome

  J Hepatol. 2017 May;66(5):930-941

  Authors : Weiss Emmanuel Rautou Pierre-Emmanuel Fasseu M Giabicani M De Chambrun M Wan Jinghong Minsart C Gustot Thierry Couvineau Alain Maiwall Hurtado-Nedelec Maria Margarita Pilard N Lebrec D Valla Dominique Durand François De La Grange P Monteiro Renato Paugam-Burtz Catherine Lotersztajn Sophie Moreau Richard

• Publication date : 29 January 2012 More

  Spatial proximity between the VPAC1 receptor and the amino terminus of agonist and antagonist peptides reveals distinct sites of interaction

  FASEB J, 2012; 26:2060-71

  Authors : Ceraudo E Hierso R Tan YV Murail S Rouyer-Fessard C Nicole Pascal Robert JC Jamin N Neumann JM Robberecht P Laburthe M Couvineau Alain