Publications

• Publication date : 28 September 2025 More

  Predictive value of metabolic state on PanNET response to mTOR inhibitors

  Endocr Relat Cancer

  Authors : Cros Jérome Margot Bucau Matthieu Tihy Maxime Palazzo Pierre Bourgoin Anais Chassac Albuquerque Miguel Sauvanet Alain Dokmak Safi Dioguardi Burgio Marco Paradis Valérie Olivia Hentic Ruszniewski Philippe De Mestier Louis Rebours Vinciane Couvelard Anne

• Publication date : 09 April 2025 More

  Protective role of oleic acid against palmitic acid-induced pancreatic fibrosis

  J Transl Med.

  Authors : Frendi Sonia Anaïs Chassac Véron Killian Raffenne Jérome Nicolle Rémy Albuquerque Miguel Paradis Valérie Couvelard Anne Cros Jérome Rebours Vinciane

• Publication date : 10 February 2025 More

  Redefining phenotypic intratumor heterogeneity of pancreatic ductal adenocarcinoma: a bottom‐up approach

  J Pathol.

  Authors : Hilmi Marc Flore Delecourt Raffenne Jérome Bourega Taib Nelson Dusetti Juan Iovanna Yuna Blum Magali Richard Cindy Neuzillet Couvelard Anne Matthieu Tihy De Mestier Louis Rebours Vinciane Nicolle Rémy Cros Jérome

• Publication date : 30 September 2024 More

  Orexins mitigate obesity-associated dysfunctions in mice

  Obesity (Silver Spring).

  Authors : Anne Blais Isabelle Denis Mireille Andriamihaja Gratio Valérie Gaelle Champeil-Potokar Laouirem Samira Anais Chassac Couvelard Anne Paradis Valérie Voisin Thierry Anne-Marie Davila Couvineau Alain

• Publication date : 18 March 2024 More

  Role of the fatty pancreatic infiltration in pancreatic oncogenesis

  Sci Rep.

  Authors : Frendi Sonia Chloé Martineau Cazier Hélène Nicolle Rémy Anaïs Chassac Albuquerque Miguel Raffenne Jérome Le Faouder Julie Paradis Valérie Cros Jérome Couvelard Anne Rebours Vinciane

• Publication date : 08 June 2023 More

  Acinar-to-Ductal Metaplasia (ADM): On the Road to Pancreatic Intraepithelial Neoplasia (PanIN) and Pancreatic Cancer

  Int J Mol Sci.

  Authors : Louis Marstrand-Daucé Lorenzo Diane Anaïs Chassac Nicole Pascal Couvelard Anne Haumaitre Cécile

• Publication date : 24 February 2023 More

  No Long-Term Mucosal Lesions in the Esophagus but More Gastric Mucosal Lesions after Sleeve Gastrectomy in Obese Rats

  J Clin Med.

  Authors : Coupaye Muriel Ribeiro-Parenti Lara Baratte Clément Muriel Hourseau Willemetz Alexandra Duboc Henri Ledoux Séverine Bado André Couvelard Anne Le Gall Maude

• Publication date : 31 August 2022 More

  Molecular deciphering of primary liver neuroendocrine neoplasms confirms their distinct existence with foregut-like profile

  J Pathol.

  Authors : De Mestier Louis Nicolle Rémy Poté Nicolas Rebours Vinciane Cauchy François Olivia Hentic Frédérique Maire Ronot Maxime Lebtahi Rachida Sauvanet Alain Paradis Valérie Ruszniewski Philippe Couvelard Anne Cros Jérome

• Publication date : 06 June 2022 More

  The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment

  Frontiers on Oncology

  Authors : Voisin Thierry Nicole Pascal Gratio Valérie Anaïs Chassac Dounia Mansour Rebours Vinciane Couvelard Anne Couvineau Alain

• Publication date : 10 March 2021 More

  Pancreatic Ductal Adenocarcinoma Arising in Young and Old Patients Displays Similar Molecular Features

  Cancers (Basel) .

  Authors : Raffenne Jérome Fernando A Martin Rémy Nicolle Marina Konta Yuna Blum Jérôme Torrisani Francesco Puleo Jean Baptiste Bachet Magali Svrcek Armel Bardier-Dupas Jean Francois Emile Peter Demetter Miroslav Radman Jean Luc Van Laethem Hammel Pascal Rebours Vinciane Paradis Valérie Couvelard Anne Cros Jérome

• Publication date : 03 January 2021 More

  Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells

  Nature Communications

  Authors : Ribeiro-Parenti Lara Anne-Charlotte Jarry Jean-Baptiste Cavin Willemetz Alexandra Le Beyec Le Bihan Johanne Aurélie Sannier Benadda Samira Pelletier Anne-Laure Muriel Hourseau Thibaut Léger Bastien Morlet Couvelard Anne Younes Anini Msika Simon Marmuse Jean-Pierre Ledoux Séverine Le Gall Maude Bado André

• Publication date : 26 October 2020 More

  Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

  Cell Rep

  Authors : Yuanchao Ye Marwa Abu El Haija Donald A Morgan Deng Guo Yang Song Aaron Frank Liping Tian Ruth A Riedl Colin M L Burnett Zhan Gao Zhiyong Zhu Shailesh K Shahi Kasra Zarei Couvelard Anne Poté Nicolas Ribeiro-Parenti Lara Bado André Lama Noureddine Andrew Bellizzi Paul Kievit Ashutosh K Mangalam Leonid V Zingman Le Gall Maude Justin L Grobe Lee M Kaplan Deborah Clegg Kamal Rahmouni Mohamad Mokadem

• Publication date : 26 October 2020 More

  Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass

  Cell Rep.

  Authors : Yuanchao Ye Marwa Abu El Haija Donald A Morgan Deng Guo Yang Song Aaron Frank Liping Tian Ruth A Riedl Colin M L Burnett Zhan Gao Zhiyong Zhu Shailesh K Shahi Kasra Zarei Couvelard Anne Poté Nicolas Ribeiro-Parenti Lara Bado André Lama Noureddine Andrew Bellizzi Paul Kievit Ashutosh K Mangalam Leonid V Zingman Le Gall Maude Justin L Grobe Lee M Kaplan Deborah Clegg Kamal Rahmouni Mohamad Mokadem

• Publication date : 17 November 2019 More

  hENT1 Testing in Pancreatic Ductal Adenocarcinoma: Are We Ready? A Multimodal Evaluation of hENT1 Status

  Cancers (Basel).

  Authors : Raffenne Jérome Nicolle R Puleo F Le Corre D Boyez C Marechal R Emile JF Demetter P Bardier A Laurent-Puig P De Mestier Louis Paradis Valérie Couvelard Anne VanLathem JL MacKey JR Bachet JB Svrcek M Cros Jérome

• Publication date : 19 June 2019 More

  Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis

  Cell Mol Gastroenterol Hepatol.

  Authors : Evans Quilichini Mélanie Fabre Thassadite Dirami Aline Stedman Matias De Vas Ozge Ozguc Raymond C Pasek Silvia Cereghini Lucie Morillon Carmen Guerra Couvelard Anne Maureen Gannon Haumaitre Cécile

• Publication date : 20 January 2019 More

  Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset

  Cancers (Basel).

  Authors : Nicolle Rémy Raffenne Jérome Paradis Valérie Couvelard Anne Aurelien de Reynies Yuna Blum Cros Jérome

• Publication date : 01 October 2018 More

  Obesity-induced pancreatopathy in rats is reversible after bariatric surgery

  Sci Rep

  Authors : Rebours Vinciane Garteiser Philippe Ribeiro-Parenti Lara Cavin JB Doblas Sabrina Page Gwenael Bado André Couvineau Alain Ruszniewski Philippe Paradis Valérie Le Gall Maude Van Beers Bernard Couvelard Anne

• Publication date : 17 August 2018 More

  Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A.

  Biochim Biophys Acta Mol Basis Dis.

  Authors : Messal N Fernandez N Dayot Stephanie Gratio Valérie Nicole Pascal Prochasson C Chantret Isabelle LeGuilloux G Jarry A Couvelard Anne Treton Xavier Voisin Thierry Ogier-Denis Eric Couvineau Alain

• Publication date : 08 January 2018 More

  In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma.

  Oncotarget.

  Authors : Dayot Stephanie Speisky D Couvelard Anne Bourgoin P Gratio Valérie Cros Jérome Rebours Vinciane Sauvanet Alain Bedossa Pierre Paradis Valérie Ruszniewski Philippe Couvineau Alain Voisin Thierry

• Publication date : 14 February 2016 More

  Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

  Gastroenterology.

  Authors : Jean-Baptiste Cavin Couvelard Anne Lebtahi Rachida Robert Ducroc Konstantinos Arapis Eglantine Voitellier Françoise Cluzeaud Laura Gillard Muriel Hourseau Nidaa Mikail Ribeiro-Parenti Lara Nathalie Kapel Marmuse Jean-Pierre Bado André Le Gall Maude

• Publication date : 29 September 2013 More

  Hypoxia pathways and cellular stress activate pancreatic stellate cells: development of an organotypic culture model of thick slices of normal human pancreas

  PLoS One, 2013;8:e76229

  Authors : Rebours Vinciane Albuquerque Miguel Sauvanet Alain Ruszniewski Philippe Levy Philippe Paradis Valérie Bedossa Pierre Couvelard Anne