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Leader(s)
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Helou Georges Doumet
- 01.57.27.78.06
- georges-doumet.helou@u-paris.fr
Mechanisms of Immunomodulation in Pulmonary Fibrosis (MIFIP)
Team Helou
Scientific axes : Junior Group
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Presentation
Despite recent advances in understanding pulmonary fibrosis, therapeutic options remain limited and often ineffective. Inflammation plays a key role in this disease, yet many of the immune mechanisms that regulate it are still poorly understood. The junior group MIFIP is dedicated to studying the immunomodulatory mechanisms involved in pulmonary fibrosis. In particular, we focus on the role of immune checkpoints in this context. These receptors, which have revolutionized cancer therapies, could also represent a promising avenue for modulating the immune response in pulmonary fibrosis and paving the way for new therapeutic strategies. Our group is supported by two ANR grants (CPJ and JCJC), a Proof of Concept grant from Inserm, as well as funding from the Fondation du Souffle and Sanofi. We also collaborate with several industrial partners, notably genOway, which enables us to evaluate immunomodulatory treatments in humanized mouse models.
Landmark publications
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Publication date : 24 September 2024 More
Updates on the controversial roles of regulatory lymphoid cells in idiopathic pulmonary fibrosis
Front Immunol.
Authors : Curioni Anna Borie Raphael Crestani Bruno Helou Georges Doumet
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Publication date : 07 May 2024 More
Iron controls the development of airway hyperreactivity by regulating ILC2 metabolism and effector function
Sci Transl Med.
Authors : Benjamin P Hurrell Yoshihiro Sakano Stephen Shen Helou Georges Doumet Meng Li Pedram Shafiei-Jahani Mohammad Hossein Kazemi Kei Sakano Xin Li Christine Quach Richard Barbers Omid Akbari
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Publication date : 31 January 2024 More
Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells
J Allergy Clin Immunol.
Authors : Helou Georges Doumet Christine Quach Marshall Fung Jacob D Painter Benjamin P Hurrell Yong-Hwee Eddie Loh Emily Howard Pedram Shafiei-Jahani Pejman Soroosh Arlene H Sharpe Omid Akbari
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Publication date : 03 January 2024 More
CXCL6 in idiopathic pulmonary fibrosis: a novel mediator in the complex epithelial-mesenchymal crosstalk
Eur Respir J.
Authors : Helou Georges Doumet Crestani Bruno
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Publication date : 19 September 2023 More
Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome
Cell Rep.
Authors : Christine Quach Helou Georges Doumet Meng Li Benjamin Pierre Hurrell Emily Howard Pedram Shafiei-Jahani Pejman Soroosh Jing-hsiung James Ou Babak Razani Virender Rehan Omid Akbari
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Publication date : 31 August 2023 More
Macrophage Implication in IPF: Updates on Immune, Epigenetic, and Metabolic Pathways
Cells.
Authors : Pokhreal Deepak Crestani Bruno Helou Georges Doumet
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Publication date : 31 December 2022 More
LAIR-1 acts as an immune checkpoint on activated ILC2s and regulates the induction of airway hyperreactivity
J Allergy Clin Immunol.
Authors : Helou Georges Doumet Pedram Shafiei-Jahani Benjamin P Hurrell Jacob D Painter Christine Quach Emily Howard Omid Akbari
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Publication date : 30 August 2022 More
PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability
Nat Commun.
Authors : Benjamin P Hurrell Helou Georges Doumet Emily Howard Jacob D Painter Pedram Shafiei-Jahani Arlene H Sharpe Omid Akbari
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Publication date : 09 August 2020 More
PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
Nat Commun.
Authors : Helou Georges Doumet Pedram Shafiei-Jahani Richard Lo Emily Howard Benjamin P Hurrell Lauriane Galle-Treger Jacob D Painter Gavin Lewis Pejman Soroosh Arlene H Sharpe Omid Akbari