The scientific focus area “Immunology, Signaling, and Cellular Dynamics” concentrates on deciphering the cellular and molecular mechanisms involving immune cells in physiological and immunopathological processes. Immune dysregulation and the resulting local or systemic inflammation are involved in a large number of chronic diseases and also promote tumor development. Studying these dysregulations and their mechanisms provides a better understanding of how these diseases occur and the contribution of the various immune players in their development, identifies therapeutic targets, and also enables the design of innovative approaches such as immunotherapies or cell therapies. We study the interactions between immune cells and/or with stromal cells and the consequences of these interactions in terms of signaling and the production of pro- and/or anti-inflammatory mediators. Our research highlights the immunopathological processes underlying various pathologies such as certain autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, mixed connective tissue disease, Sjögren’s syndrome, etc.), anti-tumor immunity, and the development of fibrotic diseases (renal, pulmonary, intestinal, or hepatic), particularly in the context of hematological and/or dysimmune pathologies.
