Auteurs

Alice Pievani,
Roberto Savoldelli,
Juliane Poelchen,
Elisa Mattioli,
Giorgio Anselmi,
Girardot Alice,
Jochen Utikal,
Bourdely Pierre,
Marta Serafini,
Guermonprez Pierre,

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Abstract

Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo.

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Autres publications

No impact of low-dose nivolumab addition to JNJ-73763989 on HBsAg declines in chronic hepatitis B: the OCTOPUS-1 study

Clin Gastroenterol Hepatol.
19 Juin 2026
Auteurs :
Asselah Tarik,
Scott K Fung,
Sila Akhan,
Wan-Long Chuang,
Maria Buti,
Maurizia Brunetto,
Kosh Agarwal,
Camellia Diba,
John Jezorwski,
Véronique Berger,
Huybrecht T'jollyn,
Wen-I Tsou,
Thomas N Kakuda,
Isabelle Lonjon-Domanec,
Catherine Nalpas,
Carine Guinard-Azadian,
Thierry Verbinnen,
Erkki Lathouwers,
An De Creus,
Oliver Lenz,
Michael Biermer,
En savoir +

Vessels encapsulating tumor clusters predict better outcomes in advanced hepatocellular carcinoma treated with atezolizumab–bevacizumab

JHEP Reports
11 Juin 2026
Auteurs :
Alexandre Sayadi,
Claudia Campani,
Astrid Laurent-Bellue,
Marianne Ziol,
Luca Di Tommaso,
Becht Etienne,
Benoit Terris,
Julien Calderaro,
Luca Messerini,
Albuquerque Miguel,
Federico Lipsich,
Carolina Gutierrez,
Marion Dhooge,
Lisa Lellouche,
Giuliana Amaddeo,
Alina Pascale,
Olivier Rosmorduc,
Fabio Marra,
Lorenza Rimassa,
Dioguardi Burgio Marco,
Beaufrère Aurélie,
En savoir +

Les basophiles favorisent la résolution et accélèrent la cicatrisation des plaies chez les souris adultes et âgées.

J Exp Med.
04 Mai 2026
Auteurs :
Bex-Coudrat Julie,
Victoria Peter,
Chaimae Saji,
Claire Dupont,
Mathilde Lavernhe,
Suoqin Jin,
Chapart Lea,
Gautier Gregory,
Thibaudeau Olivier,
Thaminy Morgane,
Tchen John,
Simon Quentin,
Xing Dai,
Kensuke Miyake,
Hajime Karasuyama,
Jean X Jiang,
Karmella Naidoo,
Benhamou Marc,
Blank Ulrich,
Monteiro Renato,
Graham Le Gros,
Agnès Coste,
Nicolas Charles,
Pellefigues Christophe,
En savoir +

Editorial for « Prospective Comparison of DWI-Derived Virtual MR Elastography and Conventional MR Elastography in Metabolic Dysfunction-Associated Steatotic Liver Disease and Healthy Volunteers

J Magn Reson Imaging.
01 Avr 2026
Auteurs :
Garteiser Philippe,
Said Omaima,
Doblas Sabrina,
Van Beers Bernard,
En savoir +