Publications

• Publication date : 21 August 2025 More

  Non-canonical Gq activation by orexin receptor type 2 and lemborexant observed in microsecond molecular dynamics simulations

  Scientific Reports

  Authors : Paulina Dragan Gratio Valérie Voisin Thierry Couvineau Alain Dorota Latek

• Publication date : 31 March 2025 More

  Pharmacodynamics of the orexin type 1 (OX1) receptor in colon cancer cell models: A two-sided nature of antagonistic ligands resulting from partial dissociation of Gq

  Br J Pharmacol.

  Authors : Gratio Valérie Paulina Dragan Garcia Laurine Saveanu Loredana Nicole Pascal Voisin Thierry Dorota Latek Couvineau Alain

• Publication date : 16 March 2025 More

  Intrapulmonary-administered myeloid derived suppressor cells rescue mice from Pseudomonas aeruginosa infection and promote a regulatory/repair phenotype

  Mucosal Immunology.

  Authors : Born-Bony Maëlys Cornu Clémentine Villeret Bérengère Gratio Valérie Romé Voulhoux Sallenave Jean-Michel

• Publication date : 30 September 2024 More

  Orexins mitigate obesity-associated dysfunctions in mice

  Obesity (Silver Spring).

  Authors : Anne Blais Isabelle Denis Mireille Andriamihaja Gratio Valérie Gaelle Champeil-Potokar Laouirem Samira Anais Chassac Couvelard Anne Paradis Valérie Voisin Thierry Anne-Marie Davila Couvineau Alain

• Publication date : 17 December 2023 More

  Identification of the Axis β-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment

  Int J Mol Sci.

  Authors : Imane Mihoub Tareck Rharass Souhaïl Ouriemmi Antonin Oudar Laure Aubard Gratio Valérie Gregory Lazarian Jordan Ferreira Elisabetta Dondi Florence Cymbalista Vincent Levy Fanny Baran-Marszak Nadine Varin-Blank Dominique Ledoux Christine Le Roy Laura Gardano

• Publication date : 27 November 2023 More

  Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

  Cytometry A.

  Authors : Gratio Valérie Dayot Stephanie Benadda Samira Nicole Pascal Saveanu Loredana Voisin Thierry Couvineau Alain

• Publication date : 27 November 2023 More

  Imaging flow cytometry of tumoroids: A new method for studying GPCR expression

  Cytometry A.

  Authors : Gratio Valérie Dayot Stephanie Benadda Samira Nicole Pascal Saveanu Loredana Voisin Thierry Couvineau Alain

• Publication date : 27 July 2022 More

  The Orexin receptors: Structural and anti-tumoral properties

  Front Endocrinol (Lausanne).

  Authors : Couvineau Alain Nicole Pascal Gratio Valérie Voisin Thierry

• Publication date : 06 June 2022 More

  The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment

  Frontiers on Oncology

  Authors : Voisin Thierry Nicole Pascal Gratio Valérie Anaïs Chassac Dounia Mansour Rebours Vinciane Couvelard Anne Couvineau Alain

• Publication date : 27 November 2021 More

  Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions

  World J Gastroenterol.

  Authors : Couvineau Alain Voisin Thierry Nicole Pascal Gratio Valérie Anne Blais

• Publication date : 17 August 2018 More

  Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A.

  Biochim Biophys Acta Mol Basis Dis.

  Authors : Messal N Fernandez N Dayot Stephanie Gratio Valérie Nicole Pascal Prochasson C Chantret Isabelle LeGuilloux G Jarry A Couvelard Anne Treton Xavier Voisin Thierry Ogier-Denis Eric Couvineau Alain

• Publication date : 08 January 2018 More

  In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma.

  Oncotarget.

  Authors : Dayot Stephanie Speisky D Couvelard Anne Bourgoin P Gratio Valérie Cros Jérome Rebours Vinciane Sauvanet Alain Bedossa Pierre Paradis Valérie Ruszniewski Philippe Couvineau Alain Voisin Thierry