Auteurs
Jessica Zucman-Rossi,
Primary liver cancer (PLC) is the third leading cause of cancer death, accounting for 830,180 deaths worldwide in 2020. PLCs are mainly composed of hepatocellular carcinoma (HCC, ∼85%) and intrahepatic cholangiocarcinoma (iCCA, ∼10%).
HCC is PLC characterized by hepatocellular differentiation; in contrast, CCAs are biliary differentiated tumors. HCC and iCCA define a spectrum of PLCs that also include mixed tumors (combined HCC-CCA [cHCC-CCA]), which are much more uncommon (∼1%). They are defined by the presence of HCC and CCA areas in various proportions, as well as, in some cases, the presence of transitional features within the same tumor.
Autres publications
18 Déc 2025
Auteurs :
Hercent Agathe,
Julien Masliah‐Planchon,
Cohen David,
Nicolle Rémy,
Jean‐Yves Scoazec,
Ruszniewski Philippe,
Ivan Bièche,
De Mestier Louis,
Couvelard Anne,
Cros Jérome,
Predictive value of metabolic state on PanNET response to mTOR inhibitors
Endocr Relat Cancer
27 Sep 2025
Auteurs :
Cros Jérome,
Margot Bucau,
Matthieu Tihy,
Maxime Palazzo,
Pierre Bourgoin,
Anais Chassac,
Albuquerque Miguel,
Sauvanet Alain,
Dokmak Safi,
Dioguardi Burgio Marco,
Paradis Valérie,
Olivia Hentic,
Ruszniewski Philippe,
De Mestier Louis,
Rebours Vinciane,
Couvelard Anne,
Non-canonical Gq activation by orexin receptor type 2 and lemborexant observed in microsecond molecular dynamics simulations
Scientific Reports
20 Août 2025
Auteurs :
Paulina Dragan,
Gratio Valérie,
Voisin Thierry,
Couvineau Alain,
Dorota Latek,
09 Avr 2025
Auteurs :
Frendi Sonia,
Anaïs Chassac,
Véron Killian,
Raffenne Jérome,
Nicolle Rémy,
Albuquerque Miguel,
Paradis Valérie,
Couvelard Anne,
Cros Jérome,
Rebours Vinciane,