{"id":84064,"date":"2026-09-09T16:04:07","date_gmt":"2026-09-09T14:04:07","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/nox1-drives-inflammatory-bowel-disease-through-oxidant-dependent-stabilization-of-i%ce%bab%ce%b6\/"},"modified":"2026-09-09T16:05:20","modified_gmt":"2026-09-09T14:05:20","slug":"nox1-drives-inflammatory-bowel-disease-through-oxidant-dependent-stabilization-of-i%ce%bab%ce%b6","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/nox1-drives-inflammatory-bowel-disease-through-oxidant-dependent-stabilization-of-i%ce%bab%ce%b6\/","title":{"rendered":"NOX1 drives inflammatory bowel disease through oxidant-dependent stabilization of I\u03baB\u03b6"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>NADPH oxidase 1 (NOX1), predominantly expressed in colonic epithelial cells, regulates mucosal immunity and homeostasis through the production of reactive oxygen species (ROS). However, its dysregulation may contribute to inflammatory bowel disease (IBD). I\u03baB\u03b6, an atypical I\u03baB family member, amplifies inflammation by inducing the expression of several pro-inflammatory genes. Here, we investigated whether NOX1 could regulate I\u03baB\u03b6 stabilization thus sustaining pro-inflammatory gene expression in IBD. NOX1 and I\u03baB\u03b6 expression were upregulated in colonic tissues and organoids from IBD patients, and this expression pattern was reproduced in healthy organoids stimulated with key inflammatory mediators associated with IBD, namely flagellin, TNF\u03b1 and IL-17. Silencing NOX1 across multiple models including T84 colonic epithelial cells, human intestinal organoids, and mice, inhibited I\u03baB\u03b6 induction in response to inflammatory mediators, demonstrating a critical role of NOX1 in regulating I\u03baB\u03b6 expression. Furthermore, ROS directly oxidized I\u03baB\u03b6 in colonic epithelial cells under inflammatory conditions, preventing its proteasomal degradation and promoting its stabilization. Mutation of cysteine 638, a solvent-exposed residue of I\u03baB\u03b6, abolished protein stabilization, suggesting that oxidation occurs at this site. Transcriptomic analysis of organoids under inflammatory conditions after silencing NOX1 or I\u03baB\u03b6, revealed that the NOX1-I\u03baB\u03b6 axis controls a network of inflammatory genes, including CCL2, identified as a hub gene. In IBD patients, elevated CCL2 secretion correlated with I\u03baB\u03b6 oxidation, reflecting increased I\u03baB\u03b6 stabilization. Together, these findings uncover a redox-sensitive NOX1-ROS-I\u03baB\u03b6 axis that sustains intestinal inflammation through I\u03baB\u03b6 stabilization and pro-inflammatory gene induction, and identify this axis as a potential therapeutic target in IBD.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0891584926009640-ga1_lrg.jpg\" alt=\"\" style=\"width:491px;height:auto\"\/><\/figure>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true},"category_publication":[404],"class_list":["post-84064","publication","type-publication","status-publish","hentry","category_publication-publications-marquantes"],"acf":{"numero_de_publication":"Free Radic Biol Med.","date_de_publication":"20260721","numero_doi":"doi.org\/10.1016\/j.freeradbiomed.2026.07.037","equipe":[376],"auteurs-liste":[{"texte_libre":false,"auteur-lien":51990,"auteur-text":""},{"texte_libre":false,"auteur-lien":83572,"auteur-text":""},{"texte_libre":false,"auteur-lien":83564,"auteur-text":""},{"texte_libre":false,"auteur-lien":83530,"auteur-text":""},{"texte_libre":false,"auteur-lien":13249,"auteur-text":""},{"texte_libre":false,"auteur-lien":80345,"auteur-text":""},{"texte_libre":false,"auteur-lien":83480,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jiao Ping"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Laura Baciou"},{"texte_libre":false,"auteur-lien":83441,"auteur-text":""},{"texte_libre":false,"auteur-lien":80319,"auteur-text":""}],"auteurs-manuel":"","liens_externes":[{"url":"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0891584926009640"}],"liens":null,"paragraphe":"","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NOX1 drives inflammatory bowel disease through oxidant-dependent stabilization of I\u03baB\u03b6 - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/en\/publication\/nox1-drives-inflammatory-bowel-disease-through-oxidant-dependent-stabilization-of-i\u03bab\u03b6\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NOX1 drives inflammatory bowel disease through oxidant-dependent stabilization of I\u03baB\u03b6 - CRI\" \/>\n<meta property=\"og:description\" content=\"Abstract NADPH oxidase 1 (NOX1), predominantly expressed in colonic epithelial cells, regulates mucosal immunity and homeostasis through the production of reactive oxygen species (ROS). However, its dysregulation may contribute to inflammatory bowel disease (IBD). I\u03baB\u03b6, an atypical I\u03baB family member, amplifies inflammation by inducing the expression of several pro-inflammatory genes. Here, we investigated whether NOX1 [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/en\/publication\/nox1-drives-inflammatory-bowel-disease-through-oxidant-dependent-stabilization-of-i\u03bab\u03b6\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2026-09-09T14:05:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ars.els-cdn.com\/content\/image\/1-s2.0-S0891584926009640-ga1_lrg.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/en\\\/publication\\\/nox1-drives-inflammatory-bowel-disease-through-oxidant-dependent-stabilization-of-i%ce%bab%ce%b6\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/en\\\/publication\\\/nox1-drives-inflammatory-bowel-disease-through-oxidant-dependent-stabilization-of-i%ce%bab%ce%b6\\\/\",\"name\":\"NOX1 drives inflammatory bowel disease through oxidant-dependent stabilization of I\u03baB\u03b6 - 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