{"id":80483,"date":"2023-04-07T17:11:54","date_gmt":"2023-04-07T17:11:54","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/"},"modified":"2023-04-07T17:11:54","modified_gmt":"2023-04-07T17:11:54","slug":"mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/","title":{"rendered":"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80483","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Nature Commun.","date_de_publication":"20230401","numero_doi":"","equipe":[391],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13180,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pushpa Hegde"},{"texte_libre":false,"auteur-lien":13254,"auteur-text":""},{"texte_libre":false,"auteur-lien":13171,"auteur-text":""},{"texte_libre":false,"auteur-lien":63550,"auteur-text":""},{"texte_libre":false,"auteur-lien":13217,"auteur-text":"Rola Al Sayegh"},{"texte_libre":false,"auteur-lien":15764,"auteur-text":"Mathilde Cadoux"},{"texte_libre":false,"auteur-lien":13172,"auteur-text":""},{"texte_libre":true,"auteur-lien":"","auteur-text":"Tristan Thibault-Sogorb"},{"texte_libre":true,"auteur-lien":"","auteur-text":"Olivier Lantz"},{"texte_libre":true,"auteur-lien":"","auteur-text":"Mich\u00e8le Goodhardt"},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pierre de la Grange"},{"texte_libre":false,"auteur-lien":80357,"auteur-text":""},{"texte_libre":false,"auteur-lien":13108,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37005415\/"}],"paragraphe":"<p><img class=\" wp-image-65880 aligncenter\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2023\/04\/MAIT-publi-Loterstajn-publi-300x166.jpg\" alt=\"\" width=\"531\" height=\"294\"><\/p>\n<p style=\"text-align: justify;\">The team led by Sophie Lotersztajn and H\u00e9l\u00e8ne Gilgenkrantz, in collaboration with V. Paradis (CRI), O. Lantz (Institut Curie) and M. Goodhardt (H\u00f4pital St Louis) have just shown that inhibiting the activation of MAIT cells (Mucosal Associated Invariant T cells) can reverse liver fibrosis. Analysis of the mechanisms involved shows that blocking the activation of MAIT cells interrupts their dialogue with profibrogenic macrophages, which play a central role in hepatic fibrosis, and promotes the emergence of fibrosis-resolving macrophages. This study opens up new therapeutic perspectives for the management of cirrhosis, for which no treatment is currently available.   <\/p>\n<blockquote>\n<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<\/blockquote>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<blockquote>\n<p style=\"text-align: justify;\">Recent data have shown that liver fibrosis can regress even at later stages of cirrhosis and shifting the immune response from pro-inflammatory towards a resolutive profile is considered as a promising option. The immune regulatory networks that govern the shift of the inflammatory phenotype and thus potential reversal of liver fibrosis are lesser known. Here we show that in precision-cut human liver slices obtained from patients with end-stage fibrosis and in mouse models, inhibiting Mucosal-Associated Invariant T (MAIT) cells using pharmacological or antibody-driven approaches, limits fibrosis progression and even regresses fibrosis, following chronic toxic- or non-alcoholic steatohepatitis (NASH)-induced liver injury. Mechanistic studies, combining RNA sequencing, in vivo functional studies (performed in male mice) and co-culture experiments indicate that disruption of the MAIT cell-monocyte\/macrophage interaction results in resolution of fibrosis both by increasing the frequency of restorative <sup>Ly6Clo<\/sup> at the expenses of pro-fibrogenic <sup>Ly6Chi<\/sup> monocyte-derived macrophages and promoting an autophagic phenotype in both subsets. Thus, our data show that MAIT cell activation and the consequential phenotype shift of liver macrophages are important pathogenic features of liver fibrosis and could be targeted by anti-fibrogenic therapy.    <\/p>\n<\/blockquote>\n<\/div>\n<p style=\"text-align: justify;\">This study was published in <em>Nature Communications <\/em>: 2023 Apr 1;14(1):1830. doi: 10.1038\/s41467-023-37453-5. PMID: 37005415  <\/p>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\\\/\",\"name\":\"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming - CRI\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#website\"},\"datePublished\":\"2023-04-07T17:11:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/cri1149.fr\\\/publication\\\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/cri1149.fr\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\\\/\\\/cri1149.fr\\\/publications\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#website\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l&#039;Inflammation\",\"publisher\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/cri1149.fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/wp-content\\\/uploads\\\/2014\\\/11\\\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\\\/\\\/cri1149.fr\\\/wp-content\\\/uploads\\\/2014\\\/11\\\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/cri-centre-de-recherche-sur-l-inflammation\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming - CRI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/","og_locale":"en_US","og_type":"article","og_title":"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming - CRI","og_url":"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/","url":"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/","name":"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming - CRI","isPartOf":{"@id":"https:\/\/cri1149.fr\/#website"},"datePublished":"2023-04-07T17:11:54+00:00","breadcrumb":{"@id":"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.fr\/publication\/mait-cell-inhibition-promotes-liver-fibrosis-regression-via-macrophage-phenotype-reprogramming\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.fr\/publications\/"},{"@type":"ListItem","position":3,"name":"MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.fr\/#website","url":"https:\/\/cri1149.fr\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l&#039;Inflammation","publisher":{"@id":"https:\/\/cri1149.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.fr\/#organization","name":"CRI1149","url":"https:\/\/cri1149.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"_links":{"self":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication\/80483","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/types\/publication"}],"acf:term":[{"embeddable":true,"taxonomy":"equipes","href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/equipes\/391"}],"wp:attachment":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/media?parent=80483"}],"wp:term":[{"taxonomy":"category_publication","embeddable":true,"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/category_publication?post=80483"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}