{"id":80481,"date":"2023-04-13T15:44:16","date_gmt":"2023-04-13T15:44:16","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/"},"modified":"2023-04-13T15:44:16","modified_gmt":"2023-04-13T15:44:16","slug":"prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/","title":{"rendered":"Prevalence of Yersinia Species in the Ileum of Crohn&#8217;s Disease Patients and Controls"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80481","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Front Cell Infect Microbiol.","date_de_publication":"20180921","numero_doi":"","equipe":[332],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Guillaume Le Baut"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Claire O'Brien"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Paul Pavli"},{"texte_libre":false,"auteur-lien":13149,"auteur-text":""},{"texte_libre":true,"auteur-lien":"","auteur-text":"Philippe Seksik"},{"texte_libre":false,"auteur-lien":13160,"auteur-text":""},{"texte_libre":true,"auteur-lien":"","auteur-text":"St\u00e9phane Nancey"},{"texte_libre":true,"auteur-lien":"","auteur-text":"Nicolas Barnich"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Madeleine Bezault"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Claire Auzolle"},{"texte_libre":false,"auteur-lien":13049,"auteur-text":""},{"texte_libre":false,"auteur-lien":13164,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matthieu Allez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"REMIND GROUP"},{"texte_libre":false,"auteur-lien":13088,"auteur-text":""},{"texte_libre":false,"auteur-lien":13067,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6160741\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\"><i>Yersinia<\/i> are common contaminants of food products, but their prevalence in the human gut is poorly documented. <i>Yersinia<\/i> have been implicated in Crohn's Disease (CD, an inflammatory bowel disease) however their role in CD is controversial. We performed highly sensitive PCR assays of specific sequences for the <i>gyrB<\/i> gene of <i>Y. aldovae, Y. bercovieri, Y. enterocolitica, Y. intermedia, Y. mollaretii<\/i> and the <i>inv<\/i> gene of <i>Y. pseudotuberculosis<\/i>. We analyzed a total of 470 ileal samples taken from 338 participants (262 CD patients and 76 controls) belonging to three independent cohorts. All patients and controls were phenotyped and genotyped for the main CD susceptibility variants: <i>NOD2, ATG16L1<\/i>, and <i>IRGM<\/i>. <i>Yersinia<\/i> were found in 7.7% of ileal samples (respectively 7.9 and 7.6% in controls and CD patients) corresponding to 10% of participants (respectively 11.8 and 9.5% in controls and CD patients). <i>Y. enterocolitica, Y. pseudotuberculosis<\/i> and <i>Y. intermedia<\/i> were the most frequently identified species. The bacteria were more frequent in resected specimens, lymph nodes and Peyer's patches. <i>Yersinia<\/i> were no more likely to be detected in CD tissues than tissues from inflammatory and non-inflammatory controls. CD patients treated with immunosuppressants were less likely to be <i>Yersinia<\/i> carriers. In conclusion, this work shows that <i>Yersinia<\/i> species are frequently found at low levels in the human ileum in health and disease. The role of <i>Yersinia<\/i> species in this ecosystem should now be explored.       <\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prevalence of Yersinia Species in the Ileum of Crohn&#039;s Disease Patients and Controls - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prevalence of Yersinia Species in the Ileum of Crohn&#039;s Disease Patients and Controls - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\",\"name\":\"Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls - CRI\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.fr\/#website\"},\"datePublished\":\"2023-04-13T15:44:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/cri1149.fr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/cri1149.fr\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Prevalence of Yersinia Species in the Ileum of Crohn&#8217;s Disease Patients and Controls\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cri1149.fr\/#website\",\"url\":\"https:\/\/cri1149.fr\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l&#039;Inflammation\",\"publisher\":{\"@id\":\"https:\/\/cri1149.fr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cri1149.fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cri1149.fr\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\/\/cri1149.fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls - CRI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/","og_locale":"en_US","og_type":"article","og_title":"Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls - CRI","og_url":"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/","url":"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/","name":"Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls - CRI","isPartOf":{"@id":"https:\/\/cri1149.fr\/#website"},"datePublished":"2023-04-13T15:44:16+00:00","breadcrumb":{"@id":"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.fr\/publication\/prevalence-of-yersinia-species-in-the-ileum-of-crohns-disease-patients-and-controls\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.fr\/publications\/"},{"@type":"ListItem","position":3,"name":"Prevalence of Yersinia Species in the Ileum of Crohn&#8217;s Disease Patients and Controls"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.fr\/#website","url":"https:\/\/cri1149.fr\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l&#039;Inflammation","publisher":{"@id":"https:\/\/cri1149.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.fr\/#organization","name":"CRI1149","url":"https:\/\/cri1149.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"_links":{"self":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication\/80481","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/types\/publication"}],"acf:term":[{"embeddable":true,"taxonomy":"equipes","href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/equipes\/332"}],"wp:attachment":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/media?parent=80481"}],"wp:term":[{"taxonomy":"category_publication","embeddable":true,"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/category_publication?post=80481"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}