{"id":80468,"date":"2023-06-30T16:12:47","date_gmt":"2023-06-30T16:12:47","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/"},"modified":"2023-06-30T16:12:47","modified_gmt":"2023-06-30T16:12:47","slug":"hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/","title":{"rendered":"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false},"category_publication":[],"class_list":["post-80468","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Hepatol","date_de_publication":"20230609","numero_doi":"","equipe":[389],"auteurs-liste":[{"texte_libre":false,"auteur-lien":14888,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nathalie Ganne-Carri\u00e9"},{"texte_libre":false,"auteur-lien":13113,"auteur-text":""},{"texte_libre":false,"auteur-lien":13245,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Shantha Ram Valainathan"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Alix Riescher-Tuczkiewicz"},{"texte_libre":false,"auteur-lien":13228,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nathalie Barget"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cendrine Chaffaut"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Alexandre Louvet"},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marianne Ziol"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Rikke B\u00e6k"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Malene M\u00f8ller J\u00f8rgensen"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Guillaume Van Niel"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pierre-Michael Coly"},{"texte_libre":false,"auteur-lien":13254,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fanny Dujardin"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Katell Peoc'h"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thierry Poynard"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sylvie Chevret"},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"CIRRAL group"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37302582\/"}],"paragraphe":"<h2><img class=\" wp-image-67683 aligncenter\" src=\"https:\/\/cri1149.fr\/wp-content\/uploads\/2023\/06\/Laure-V3-1-300x240.png\" alt=\"\" width=\"738\" height=\"590\"><\/h2>\n<h2 class=\"x_x_title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"x_x_eng-abstract\" class=\"x_x_abstract-content x_x_selected\">\n<p class=\"\" style=\"text-align: justify;\">In patients with compensated alcohol-related cirrhosis, reliable prognostic biomarkers are lacking. Keratin-18 and hepatocyte-derived large extracellular vesicles (lEVs) concentrations reflect disease activity, but their ability to predict liver-related events is unknown. <\/p>\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Methods: <\/strong>We measured plasma keratin-18 and hepatocyte lEVs concentrations in 500 patients with Child-Pugh class A alcohol-related cirrhosis. Ability of these hepatocyte-derived biomarkers, alone or combined with MELD and FibroTest, to predict liver-related events at 2 years was analyzed, taking into account the alcohol consumption at inclusion and during the follow-up. <\/p>\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Results: <\/strong>Keratin-18 and hepatocyte lEVs concentrations increased with alcohol consumption. In patients without active alcohol consumption at enrollment (n=419), keratin-18 concentration predicted liver-related events at 2 years, independently of FibroTest and MELD. Patients with both keratin-18 concentration >285 U\/L and FibroTest >0.74 had a 24% cumulative incidence of liver-related events at 2 years, versus 5% to 14% in other groups of patients. Similar results were obtained when combining keratin-18 concentration >285 U\/L with MELD >10. In patients with active alcohol consumption at enrollment (n=81), hepatocyte lEVs predicted liver-related events at 2 years, independently of FibroTest and MELD. Patients with both hepatocyte lEVs concentration >50 U\/L and FibroTest>0.74 had a 62% cumulative incidence of liver-related events at 2 years, versus 8% to 13% in other groups of patients. Combining hepatocyte lEVs concentration >50 U\/L with MELD >10 had a lower discrimination ability. Similar results were obtained using as endpoint decompensation of cirrhosis defined according Baveno VII criteria.      <\/p>\n<p class=\"\" style=\"text-align: justify;\"><strong class=\"x_x_sub-title\">Conclusion: <\/strong>In patients with Child-Pugh class A alcohol-related cirrhosis, combining hepatocyte-derived biomarkers with FibroTest or MELD score identifies patients at high-risk of liver-related events, and could be used for risk stratification and patient selection in clinical trials. <\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\\\/\",\"name\":\"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - CRI\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#website\"},\"datePublished\":\"2023-06-30T16:12:47+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/cri1149.fr\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\\\/\\\/cri1149.fr\\\/publications\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#website\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l&#039;Inflammation\",\"publisher\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/cri1149.fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/wp-content\\\/uploads\\\/2014\\\/11\\\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\\\/\\\/cri1149.fr\\\/wp-content\\\/uploads\\\/2014\\\/11\\\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/cri-centre-de-recherche-sur-l-inflammation\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - CRI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/","og_locale":"en_US","og_type":"article","og_title":"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - CRI","og_url":"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/","url":"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/","name":"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis - CRI","isPartOf":{"@id":"https:\/\/cri1149.fr\/#website"},"datePublished":"2023-06-30T16:12:47+00:00","breadcrumb":{"@id":"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.fr\/publication\/hepatocyte-derived-biomarkers-predict-liver-related-events-at-2-years-in-child-pugh-class-a-alcohol-related-cirrhosis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.fr\/publications\/"},{"@type":"ListItem","position":3,"name":"Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.fr\/#website","url":"https:\/\/cri1149.fr\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l&#039;Inflammation","publisher":{"@id":"https:\/\/cri1149.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.fr\/#organization","name":"CRI1149","url":"https:\/\/cri1149.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"_links":{"self":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication\/80468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/types\/publication"}],"acf:term":[{"embeddable":true,"taxonomy":"equipes","href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/equipes\/389"}],"wp:attachment":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/media?parent=80468"}],"wp:term":[{"taxonomy":"category_publication","embeddable":true,"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/category_publication?post=80468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}