{"id":80466,"date":"2023-07-13T17:10:58","date_gmt":"2023-07-13T17:10:58","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/genetic-ancestry-race-and-severity-of-acutely-decompensated-cirrhosis-in-latin-america\/"},"modified":"2023-07-13T17:10:58","modified_gmt":"2023-07-13T17:10:58","slug":"genetic-ancestry-race-and-severity-of-acutely-decompensated-cirrhosis-in-latin-america","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/genetic-ancestry-race-and-severity-of-acutely-decompensated-cirrhosis-in-latin-america\/","title":{"rendered":"Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin 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Queiroz Farias"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Anna Curto Vilalta"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Patr\u00edcia Momoyo Zitelli"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Gustavo Pereira"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Luciana L Goncalves"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Aldo Torre"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Juan Manuel Diaz"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Adrian C Gadano"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Angelo Z Mattos"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Liliana S C Mendes"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mario R Alvares-da-Silva"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Paulo L Bittencourt"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Carlos Benitez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Claudia Alves Couto"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Manuel Mendizabal"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Claudio L Toledo"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Daniel F Mazo"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mauricio Castillo Barradas"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Eva M Uson Raposo"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"P Mart\u00edn Padilla-Machaca"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Adelina Zarela Lozano Miranda"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ren\u00e9 Mal\u00e9-Vel\u00e1zquez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Andr\u00e9 Castro Lyra"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Milagros B D\u00e1valos-Moscol"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jose L P\u00e9rez Hernandez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Rafael O Ximenes "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Giovanni Faria Silva"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Oscar A Beltr\u00e1n-Galvis"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mar\u00eda S Gonz\u00e1lez Huezo"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fernando Bessone"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Tarciso D S Rocha"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Eduardo Fassio"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Carlos Terra"},{"texte_libre":true,"auteur-lien":null,"auteur-text":" Juan I Mar\u00edn"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Patricia Sierra Casas"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Carlos de la Pe\u00f1a-Ramirez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ferran Aguilar Parera"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Flavia Fernandes"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Maria da Penha Zago-Gomes"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Osvely M\u00e9ndez-Guerrero"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sebasti\u00e1n Marciano"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Angelo A Mattos"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Joao C Oliveira "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Gabriel T S Guerreiro"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Liana Codes"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marco Arrese"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mateus J Nardelli "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marcelo O Silva "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Renato Palma-Fernandez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Camila Alcantara"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cristina S\u00e1nchez Garrido "},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jonel Trebicka"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thierry Gustot"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Javier Fern\u00e1ndez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Joan Cl\u00e0ria"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Rajiv Jalan"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Paolo Angeli"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Vicente Arroyo"},{"texte_libre":false,"auteur-lien":13124,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Flair J Carrilho"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"ACLARA Study Collaborators"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37263305\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Background & aims: <\/strong>Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic ancestry and race with acute-on-chronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure, and high risk of short-term death.<\/p>\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Methods: <\/strong>This prospective cohort study analyzed a comprehensive set of data, including genetic ancestry and race among several others, in 1274 patients with acutely decompensated cirrhosis who were nonelectively admitted to 44 hospitals from 7 Latin American countries.<\/p>\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results: <\/strong>Three hundred ninety-five patients (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had a higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4% vs 59.6%, respectively). The median percentage of African genetic ancestry was low among patients with ACLF and among those without ACLF. In terms of race, a higher percentage of patients with ACLF than patients without ACLF were Native American and a lower percentage of patients with ACLF than patients without ACLF were European American or African American. In multivariable analyses that adjusted for differences in sociodemographic and clinical characteristics, the odds ratio for ACLF at enrollment was 1.08 (95% CI, 1.03-1.13) with Native American genetic ancestry and 2.57 (95% CI, 1.84-3.58) for Native American race vs European American race CONCLUSIONS: In a large cohort of Latin American patients with acutely decompensated cirrhosis, increasing percentages of Native American ancestry and Native American race were factors independently associated with ACLF at enrollment.<\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/genetic-ancestry-race-and-severity-of-acutely-decompensated-cirrhosis-in-latin-america\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America - 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