{"id":80462,"date":"2023-09-14T15:11:33","date_gmt":"2023-09-14T15:11:33","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/activating-fc%ce%b3r-function-depends-on-endosomal-signaling-platforms\/"},"modified":"2023-09-14T15:11:33","modified_gmt":"2023-09-14T15:11:33","slug":"activating-fc%ce%b3r-function-depends-on-endosomal-signaling-platforms","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/activating-fc%ce%b3r-function-depends-on-endosomal-signaling-platforms\/","title":{"rendered":"Activating Fc\u03b3R function depends on endosomal-signaling platforms"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80462","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"iScience.","date_de_publication":"20230609","numero_doi":"","equipe":[390],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13032,"auteur-text":""},{"texte_libre":false,"auteur-lien":16172,"auteur-text":""},{"texte_libre":false,"auteur-lien":16349,"auteur-text":""},{"texte_libre":false,"auteur-lien":13031,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mariacristina De Luca"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Olivier Pell\u00e9"},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""},{"texte_libre":false,"auteur-lien":13182,"auteur-text":""},{"texte_libre":false,"auteur-lien":13153,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37360697\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\">Cell surface receptor internalization can either terminate signaling or activate alternative endosomal signaling pathways. We investigated here whether endosomal signaling is involved in the function of the human receptors for Fc immunoglobulin fragments (FcRs): Fc\u03b1RI, Fc\u03b3RIIA, and Fc\u03b3RI. All these receptors were internalized after their cross-linking with receptor-specific antibodies, but their intracellular trafficking was different. Fc\u03b1RI was targeted directly to lysosomes, while Fc\u03b3RIIA and Fc\u03b3RI were internalized in particular endosomal compartments described by the insulin esponsive minoeptidase (IRAP), where they recruited signaling molecules, such as the active form of the kinase Syk, PLC\u03b3 and the adaptor LAT. Destabilization of Fc\u03b3R endosomal signaling in the absence of IRAP compromised cytokine secretion downstream Fc\u03b3R activation and macrophage ability to kill tumor cells by antibody-dependent cell-mediated cytotoxicity (ADCC). Our results indicate that Fc\u03b3R endosomal signaling is required for the Fc\u03b3R-driven inflammatory reaction and possibly for the therapeutic action of monoclonal antibodies.     <\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Activating Fc\u03b3R function depends on endosomal-signaling platforms - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/activating-fc\u03b3r-function-depends-on-endosomal-signaling-platforms\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Activating Fc\u03b3R function depends on endosomal-signaling platforms - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/activating-fc\u03b3r-function-depends-on-endosomal-signaling-platforms\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/activating-fc%ce%b3r-function-depends-on-endosomal-signaling-platforms\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/activating-fc%ce%b3r-function-depends-on-endosomal-signaling-platforms\\\/\",\"name\":\"Activating Fc\u03b3R function depends on endosomal-signaling platforms - 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