{"id":80455,"date":"2023-09-22T16:24:46","date_gmt":"2023-09-22T16:24:46","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/hepatitis-b-virus-infection-and-extra-hepatic-manifestations-a-systemic-disease\/"},"modified":"2023-09-22T16:24:46","modified_gmt":"2023-09-22T16:24:46","slug":"hepatitis-b-virus-infection-and-extra-hepatic-manifestations-a-systemic-disease","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/hepatitis-b-virus-infection-and-extra-hepatic-manifestations-a-systemic-disease\/","title":{"rendered":"Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80455","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Am J Gastroenterol.","date_de_publication":"20220201","numero_doi":"","equipe":[331],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Patrice Cacoub"},{"texte_libre":false,"auteur-lien":78525,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/34913875\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\">People living with hepatitis B virus (HBV) chronic infection are exposed to high rates of liver complications including end-stage liver disease and hepatocellular carcinoma. Extrahepatic manifestations of HBV infection have long been underestimated. Several of these extrahepatic syndromes have been well described, including systemic vasculitides, glomerulonephritis, and cutaneous manifestations. Other manifestations have been more recently described such as hematological malignancies and neurological diseases. These extrahepatic manifestations are associated with significant morbidity and mortality. Although not completely understood, underlying mechanisms include HBV-induced local and systemic inflammation. Suppression of HBV replication usually improves extrahepatic manifestations. This review will discuss how HBV induces inflammation and the extrahepatic manifestations of HBV infection to guide clinical management.       <\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/hepatitis-b-virus-infection-and-extra-hepatic-manifestations-a-systemic-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/hepatitis-b-virus-infection-and-extra-hepatic-manifestations-a-systemic-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatitis-b-virus-infection-and-extra-hepatic-manifestations-a-systemic-disease\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/hepatitis-b-virus-infection-and-extra-hepatic-manifestations-a-systemic-disease\\\/\",\"name\":\"Hepatitis B Virus Infection and Extra-Hepatic Manifestations: A Systemic Disease - 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