{"id":80445,"date":"2023-10-16T16:52:02","date_gmt":"2023-10-16T16:52:02","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/"},"modified":"2023-10-16T16:52:02","modified_gmt":"2023-10-16T16:52:02","slug":"role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/","title":{"rendered":"Role of adherent and invasive Escherichia coli in Crohn’s disease: lessons from the postoperative recurrence model"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80445","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Gut.","date_de_publication":"20230101","numero_doi":"","equipe":[332],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Anthony Buisson"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Harry Sokol"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nassim Hammoudi"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"St\u00e9phane Nancey"},{"texte_libre":false,"auteur-lien":13160,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Maria Nachury"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Mathurin Fumery"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Xavier H\u00e9buterne"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Michael Rodrigues"},{"texte_libre":false,"auteur-lien":13088,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Gilles Boschetti"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Carmen Stefanescu"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pauline Wils"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Philippe Seksik"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lionel Le Bourhis"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Madeleine Bezault"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pierre Sauvanet"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Bruno Pereira"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matthieu Allez"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nicolas Barnich"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Remind study group"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/35361684\/"}],"paragraphe":"

Abstract<\/h2>\n
\n

Objective: <\/strong>We used the postoperative recurrence model to better understand the role of adherent and invasive Escherichia coli<\/i> (AIEC) bacteria in Crohn's disease (CD), taking advantage of a well-characterised postoperative cohort.<\/p>\n

Design: <\/strong>From a prospective, multicentre cohort of operated patients with CD, AIEC identification was performed within the surgical specimen (M0) (N=181 patients) and the neoterminal ileum (n=119 patients\/181) during colonoscopy performed 6 months after surgery (M6). Endoscopic postoperative recurrence was graded using Rutgeerts' index. The mucosa-associated microbiota was analysed by 16S sequencing at M0 and M6. Relative risks or ORs were adjusted on potential confounders. <\/p>\n

Results: <\/strong>AIEC prevalence was twofold higher within the neoterminal ileum at M6 (30.3%) than within the surgical specimen (14.9%) (p<0.001). AIEC within the neoterminal ileum at M6 was associated with higher rate of early ileal lesions (i1) (41.6% vs 17.1%; aRR 3.49 (95% CI 1.01 to 12.04), p=0.048) or ileal lesions (i2b+i3) (38.2% vs 17.1%; aRR 3.45 (95% CI 1.06 to 11.30), p=0.040) compared with no lesion (i0). AIEC within the surgical specimen was predictive of higher risk of i2b-endoscopic postoperative recurrence (POR) (aOR 2.54 (95% CI 1.01 to 6.44), p=0.049) and severe endoscopic POR (aOR 3.36 (95% CI 1.25 to 9.06), p=0.017). While only 5.0% (6\/119) of the patients were AIEC-positive at both M0 and M6, 43.7% (52\/119), patients with history of positive test for AIEC (M0 or M6) had higher risk of ileal endoscopic POR (aOR 2.32 (95% CI 1.01 to 5.39), p=0.048)), i2b-endoscopic postoperative recurrence (aOR 2.41 (95% CI 1.01 to 5.74); p=0.048) and severe endoscopic postoperative (aOR=3.84 (95% CI 1.32 to 11.18), p=0.013). AIEC colonisation was associated with a specific microbiota signature including increased abundance of Ruminococcus gnavus<\/i>. <\/p>\n

Conclusion: <\/strong>Based on the postoperative recurrence model, our data support the idea that AIEC are involved in the early steps of ileal CD.<\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"\nRole of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/role-of-adherent-and-invasive-escherichia-coli-in-crohns-disease-lessons-from-the-postoperative-recurrence-model\/\",\"name\":\"Role of adherent and invasive Escherichia coli in Crohn's disease: lessons from the postoperative recurrence model - 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