{"id":80430,"date":"2023-12-10T00:28:16","date_gmt":"2023-12-10T00:28:16","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/"},"modified":"2023-12-10T00:28:16","modified_gmt":"2023-12-10T00:28:16","slug":"differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/","title":{"rendered":"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80430","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Histopathology.","date_de_publication":"20231030","numero_doi":"","equipe":[337],"auteurs-liste":[{"texte_libre":false,"auteur-lien":63210,"auteur-text":""},{"texte_libre":false,"auteur-lien":13213,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ibrahima Ba"},{"texte_libre":false,"auteur-lien":13096,"auteur-text":""},{"texte_libre":false,"auteur-lien":63205,"auteur-text":""},{"texte_libre":false,"auteur-lien":14852,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lo\u00ebtitia Favre"},{"texte_libre":false,"auteur-lien":63209,"auteur-text":""},{"texte_libre":false,"auteur-lien":71742,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Julien Calderaro"},{"texte_libre":false,"auteur-lien":13092,"auteur-text":""},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""}],"auteurs-manuel":" ","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37903649\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Aims: <\/strong>The differential diagnosis of small hepatocellular nodules in cirrhosis between dysplastic nodules and hepatocellular carcinoma (HCC) remains challenging on biopsy. As TERT promoter (pTERT) mutations may indicate the nodules already engaged in the malignant process, the aim of this study was to identify histological criteria associated with pTERT mutations by detecting these mutations by ddPCR in small formalin-fixed paraffin-embedded (FFPE) hepatocellular nodules arising in cirrhosis. <\/p>\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Methods and results: <\/strong>We built a bicentric cohort data set of 339 hepatocellular nodules < 2 cm from cirrhotic samples, divided into a test cohort of 299 resected samples and a validation cohort of 40 biopsies. Pathological review, based on the evaluation of 14 histological criteria, classified all nodules. pTERT mutations were identified by ddPCR in FFPE samples. Among the 339 nodules, ddPCR revealed pTERT mutations in 105 cases (31%), including 90 and 15 cases in the test and validation cohorts, respectively. On multivariate analysis, three histological criteria were associated with pTERT mutations in the test cohort: increased cell density (P = 0.003), stromal invasion (P = 0.036) and plate-thickening anomalies (P < 0.001). With the combination of at least two of these major criteria, the AUC for predicting pTERT mutations was 0.84 in the test cohort (sensitivity: 86%, specificity: 83%) and 0.81 in the validation cohort (sensitivity: 87%, specificity: 76%).     <\/p>\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions: <\/strong>We identified three histological criteria as surrogate markers of pTERT mutations that may be used in routine biopsy to more clearly classify small hepatocellular nodules arising in cirrhosis.<\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/\",\"name\":\"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations - CRI\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.fr\/#website\"},\"datePublished\":\"2023-12-10T00:28:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/cri1149.fr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/cri1149.fr\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cri1149.fr\/#website\",\"url\":\"https:\/\/cri1149.fr\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l&#039;Inflammation\",\"publisher\":{\"@id\":\"https:\/\/cri1149.fr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cri1149.fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cri1149.fr\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\/\/cri1149.fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations - CRI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/","og_locale":"en_US","og_type":"article","og_title":"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations - CRI","og_url":"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/","url":"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/","name":"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations - CRI","isPartOf":{"@id":"https:\/\/cri1149.fr\/#website"},"datePublished":"2023-12-10T00:28:16+00:00","breadcrumb":{"@id":"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.fr\/publication\/differential-diagnosis-of-small-hepatocellular-nodules-in-cirrhosis-surrogate-histological-criteria-of-tert-promoter-mutations\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.fr\/publications\/"},{"@type":"ListItem","position":3,"name":"Differential diagnosis of small hepatocellular nodules in cirrhosis: surrogate histological criteria of TERT promoter mutations"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.fr\/#website","url":"https:\/\/cri1149.fr\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l&#039;Inflammation","publisher":{"@id":"https:\/\/cri1149.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.fr\/#organization","name":"CRI1149","url":"https:\/\/cri1149.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"_links":{"self":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication\/80430","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/types\/publication"}],"acf:term":[{"embeddable":true,"taxonomy":"equipes","href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/equipes\/337"}],"wp:attachment":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/media?parent=80430"}],"wp:term":[{"taxonomy":"category_publication","embeddable":true,"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/category_publication?post=80430"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}