{"id":80423,"date":"2024-03-07T17:54:29","date_gmt":"2024-03-07T17:54:29","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/the-immunological-landscape-in-pancreatic-ductal-adenocarcinoma-and-overcoming-resistance-to-immunotherapy\/"},"modified":"2024-03-07T17:54:29","modified_gmt":"2024-03-07T17:54:29","slug":"the-immunological-landscape-in-pancreatic-ductal-adenocarcinoma-and-overcoming-resistance-to-immunotherapy","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/the-immunological-landscape-in-pancreatic-ductal-adenocarcinoma-and-overcoming-resistance-to-immunotherapy\/","title":{"rendered":"The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80423","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Lancet Gastroenterol Hepatol.","date_de_publication":"20231201","numero_doi":"10.1016\/S2468-1253(23)00207-8","equipe":[387],"auteurs-liste":[{"texte_libre":false,"auteur-lien":62621,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matthieu Delaye"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Milena Muzzolini"},{"texte_libre":false,"auteur-lien":47152,"auteur-text":""},{"texte_libre":false,"auteur-lien":13055,"auteur-text":""},{"texte_libre":false,"auteur-lien":13087,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Victoire Cardot-Ruffino"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cindy Neuzillet"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37866368\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\">Pancreatic ductal adenocarcinoma is associated with a poor prognosis and there are few treatment options. The development of immunotherapy in pancreatic ductal adenocarcinoma has been difficult, and immune checkpoint inhibitors are only effective in a very small subset of patients. Most obstacles for treatment have been related to intertumoural and intratumoural heterogeneity, the composition of tumour stroma, and crosstalk with cancer cells. Improved molecular characterisation of pancreatic ductal adenocarcinoma and a better understanding of its microenvironment have paved the way for novel immunotherapy strategies, including the identification of predictive biomarkers, the development of rational combinations to optimise effectiveness, and the targeting of new mechanisms. Future immunotherapy strategies should consider individual characteristics to move beyond the traditional immune targets and circumvent the resistance to therapies that have been developed so far.    <\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/the-immunological-landscape-in-pancreatic-ductal-adenocarcinoma-and-overcoming-resistance-to-immunotherapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The immunological landscape in pancreatic ductal adenocarcinoma and overcoming resistance to immunotherapy - 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