{"id":80421,"date":"2024-03-07T17:41:12","date_gmt":"2024-03-07T17:41:12","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/hepatocellular-carcinoma-in-patients-with-non-alcoholic-fatty-liver-disease-is-associated-with-heterogeneous-pattern-of-fat-infiltration-in-skeletal-muscles\/"},"modified":"2024-03-07T17:41:12","modified_gmt":"2024-03-07T17:41:12","slug":"hepatocellular-carcinoma-in-patients-with-non-alcoholic-fatty-liver-disease-is-associated-with-heterogeneous-pattern-of-fat-infiltration-in-skeletal-muscles","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/hepatocellular-carcinoma-in-patients-with-non-alcoholic-fatty-liver-disease-is-associated-with-heterogeneous-pattern-of-fat-infiltration-in-skeletal-muscles\/","title":{"rendered":"Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease is associated with heterogeneous pattern of fat infiltration in skeletal muscles"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80421","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Eur Radiol.","date_de_publication":"20240301","numero_doi":"10.1007\/s00330-023-10131-2","equipe":[377],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Maxime Nachit"},{"texte_libre":false,"auteur-lien":14728,"auteur-text":""},{"texte_libre":false,"auteur-lien":13183,"auteur-text":""},{"texte_libre":false,"auteur-lien":13077,"auteur-text":""},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":false,"auteur-lien":13166,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Isabelle Leclercq"},{"texte_libre":false,"auteur-lien":13162,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/37658893\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Objectives: <\/strong>To evaluate the association between fat infiltration in skeletal muscles (myosteatosis) and hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD).<\/p>\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Methods: <\/strong>In a cross-sectional cohort of 72 histologically proven NAFLD patients (n = 38 with non-alcoholic steatohepatitis; NASH), among which 20 had HCC diagnosed on biopsy, we used proton density fat fraction (PDFF) at MRI to evaluate myosteatosis in skeletal muscles (mean fat fraction and first order radiomic-based pattern) at the third lumbar level, namely in erector spinae (ES), quadratus lumborum (QL), psoas, oblique, and rectus muscles.<\/p>\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results: <\/strong>PDFF<sub>ES<\/sub> was 70% higher in patients with HCC when compared to those without HCC (9.6 \u00b1 5.5% versus 5.7 \u00b1 3.0%, respectively, p < 0.001). In multivariate logistic regression, PDFF<sub>ES<\/sub> was a significant predictor of the presence of HCC (AUC = 0.72, 95% CI 0.57-0.86, p = 0.002) independently from age, sex, visceral fat area, and liver fibrosis stage (all p < 0.05). The relationship between PDFF<sub>ES<\/sub> and HCC was exacerbated in patients with NASH (AUC = 0.79, 95% CI 0.63-0.86, p = 0.006). In patients with NASH, radiomics features of heterogeneity such as energy and entropy in any of the paraspinal muscles (i.e., ES, QL, or psoas) were independent predictors of HCC. Energy<sub>ES<\/sub> identified patients with HCC (n = 13) in the NASH population with AUC = 0.92 (95% CI 0.82-1.00, p < 0.001).<\/p>\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusion: <\/strong>In patients with NAFLD, and more specifically in those with NASH, the degree and heterogeneity of myosteatosis is independently associated with HCC irrespective of liver fibrosis stage.<\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease is associated with heterogeneous pattern of fat infiltration in skeletal muscles - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/hepatocellular-carcinoma-in-patients-with-non-alcoholic-fatty-liver-disease-is-associated-with-heterogeneous-pattern-of-fat-infiltration-in-skeletal-muscles\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hepatocellular carcinoma in patients with non-alcoholic fatty liver disease is associated with heterogeneous pattern of fat infiltration in skeletal muscles - 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