{"id":80420,"date":"2024-02-15T08:52:37","date_gmt":"2024-02-15T08:52:37","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/identification-of-the-axis-%ce%b2-catenin-btk-in-the-dynamic-adhesion-of-chronic-lymphocytic-leukemia-cells-to-their-microenvironment\/"},"modified":"2024-02-15T08:52:37","modified_gmt":"2024-02-15T08:52:37","slug":"identification-of-the-axis-%ce%b2-catenin-btk-in-the-dynamic-adhesion-of-chronic-lymphocytic-leukemia-cells-to-their-microenvironment","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/identification-of-the-axis-%ce%b2-catenin-btk-in-the-dynamic-adhesion-of-chronic-lymphocytic-leukemia-cells-to-their-microenvironment\/","title":{"rendered":"Identification of the Axis \u03b2-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80420","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Int J Mol Sci.","date_de_publication":"20231218","numero_doi":"","equipe":[],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Imane Mihoub"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Tareck Rharass"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Souha\u00efl Ouriemmi"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Antonin Oudar"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Laure Aubard"},{"texte_libre":false,"auteur-lien":80348,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Gregory Lazarian"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jordan Ferreira"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Elisabetta Dondi"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Florence Cymbalista"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Vincent Levy"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Fanny Baran-Marszak"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Nadine Varin-Blank"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Dominique Ledoux"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Christine Le Roy"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Laura Gardano"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/38139452\/"}],"paragraphe":"<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p style=\"text-align: justify;\">In the microenvironment, cell interactions are established between different cell types to regulate their migration, survival and activation. \u03b2-Catenin is a multifunctional protein that stabilizes cell-cell interactions and regulates cell survival through its transcriptional activity. We used chronic lymphocytic leukemia (CLL) cells as a cellular model to study the role of \u03b2-catenin in regulating the adhesion of tumor cells to their microenvironment, which is necessary for tumor cell survival and accumulation. When co-cultured with a stromal cell line (HS-5), a fraction of the CLL cells adhere to stromal cells in a dynamic fashion regulated by the different levels of \u03b2-catenin expression. In non-adherent cells, \u03b2-catenin is stabilized in the cytosol and translocates into the nucleus, increasing the expression of cyclin D1. In adherent cells, the level of cytosolic \u03b2-catenin is low but membrane \u03b2-catenin helps to stabilize the adhesion of CLL to stromal cells. Indeed, the overexpression of \u03b2-catenin enhances the interaction of CLL with HS-5 cells, suggesting that this protein behaves as a regulator of cell adhesion to the stromal component and of the transcriptional regulation of cell survival. Inhibitors that block the stabilization of \u03b2-catenin alter this equilibrium and effectively disrupt the support that CLL cells receive from the cross-talk with the stroma.       <\/p>\n<\/div>","paragraphe_en":"","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identification of the Axis \u03b2-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/identification-of-the-axis-\u03b2-catenin-btk-in-the-dynamic-adhesion-of-chronic-lymphocytic-leukemia-cells-to-their-microenvironment\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identification of the Axis \u03b2-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment - 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