{"id":80399,"date":"2025-02-19T12:40:51","date_gmt":"2025-02-19T12:40:51","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/"},"modified":"2025-02-19T12:40:51","modified_gmt":"2025-02-19T12:40:51","slug":"enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/","title":{"rendered":"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80399","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Cell Rep.","date_de_publication":"20230920","numero_doi":"10.1016\/j.celrep.2023.112990","equipe":[383],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Christine Quach"},{"texte_libre":false,"auteur-lien":73990,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Meng Li"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Benjamin Pierre Hurrell"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Emily Howard"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pedram Shafiei-Jahani"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pejman Soroosh"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jing-hsiung James Ou"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Babak Razani"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Virender Rehan"},{"texte_libre":true,"auteur-lien":null,"auteur-text":" Omid Akbari"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10510741\/"}],"paragraphe":"

SUMMARY<\/h2>\n

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical disorders that mainly develop from viral respiratory infections, sepsis, and chest injury. Antigen-presenting cells play a pivotal role in propagating uncontrolled inflammation and injury through the excess secretion of pro-inflammatory cytokines and recruitment of immune cells. Autophagy, a homeostatic process that involves the degradation of cellular components, is involved in many processes including lung inflammation. Here, we use a polyinosinic-polycytidylic acid (poly(I:C))-induced lung injury mouse model to mimic viral-induced ALI\/ARDS and show that disruption of autophagy in macrophages exacerbates lung inflammation and injury, whereas autophagy induction attenuates this process. Therefore, induction of autophagy in macrophages can be a promising therapeutic strategy in ALI\/ARDS. <\/p>","paragraphe_en":"","documents":null},"yoast_head":"\nEnhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\\\/\",\"name\":\"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#website\"},\"datePublished\":\"2025-02-19T12:40:51+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/cri1149.fr\\\/publication\\\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/cri1149.fr\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\\\/\\\/cri1149.fr\\\/publications\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#website\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l'Inflammation\",\"publisher\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/cri1149.fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/wp-content\\\/uploads\\\/2014\\\/11\\\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\\\/\\\/cri1149.fr\\\/wp-content\\\/uploads\\\/2014\\\/11\\\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\\\/\\\/cri1149.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/cri-centre-de-recherche-sur-l-inflammation\\\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/","og_locale":"en_US","og_type":"article","og_title":"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI","og_url":"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/","url":"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/","name":"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome - CRI","isPartOf":{"@id":"https:\/\/cri1149.fr\/#website"},"datePublished":"2025-02-19T12:40:51+00:00","breadcrumb":{"@id":"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.fr\/publication\/enhancing-autophagy-in-cd11c-antigen-presenting-cells-as-a-therapeutic-strategy-for-acute-respiratory-distress-syndrome\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.fr\/publications\/"},{"@type":"ListItem","position":3,"name":"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.fr\/#website","url":"https:\/\/cri1149.fr\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l'Inflammation","publisher":{"@id":"https:\/\/cri1149.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.fr\/#organization","name":"CRI1149","url":"https:\/\/cri1149.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"_links":{"self":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication\/80399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/types\/publication"}],"acf:term":[{"embeddable":true,"taxonomy":"equipes","href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/equipes\/383"}],"wp:attachment":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/media?parent=80399"}],"wp:term":[{"taxonomy":"category_publication","embeddable":true,"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/category_publication?post=80399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}