{"id":80397,"date":"2025-02-20T11:11:03","date_gmt":"2025-02-20T11:11:03","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/human-pd-1-agonist-treatment-alleviates-neutrophilic-asthma-by-reprogramming-t-cells\/"},"modified":"2025-02-20T11:11:03","modified_gmt":"2025-02-20T11:11:03","slug":"human-pd-1-agonist-treatment-alleviates-neutrophilic-asthma-by-reprogramming-t-cells","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/human-pd-1-agonist-treatment-alleviates-neutrophilic-asthma-by-reprogramming-t-cells\/","title":{"rendered":"Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80397","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"J Allergy Clin Immunol.","date_de_publication":"20240201","numero_doi":"10.1016\/j.jaci.2022.07.022","equipe":[383],"auteurs-liste":[{"texte_libre":false,"auteur-lien":73990,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Christine Quach"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marshall Fung"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jacob D Painter"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Benjamin P Hurrell"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Yong-Hwee Eddie Loh"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Emily Howard"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pedram Shafiei-Jahani"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Pejman Soroosh"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Arlene H Sharpe"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Omid Akbari"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9905221\/"}],"paragraphe":"

Abstract<\/h2>\n
\n

Background:<\/h3>\n

Neutrophilic asthma is associated with disease severity and corticosteroid insensitivity. Novel therapies are required to manage this life-threatening asthma phenotype. Programmed cell death protein-1 (PD-1) is a key homeostatic modulator of the immune response for T cell effector functions. <\/p>\n<\/section>\n

\n

Objective:<\/h3>\n

Our aim here was to investigate the role of PD-1 in the regulation of acute neutrophilic inflammation in a murine model of airway hyperreactivity (AHR).<\/p>\n<\/section>\n

\n

Methods:<\/h3>\n

House dust mite was used to induce and compare neutrophilic AHR in wild-type and PD-1 knockout mice. Then the therapeutic potential of a human PD-1 agonist was tested in a humanized mouse model in which the PD-1 extracellular domain is entirely humanized. Single-cell RNA sequencing and flow cytometry were mainly used to investigate molecular and cellular mechanisms. <\/p>\n<\/section>\n

\n

Results:<\/h3>\n

PD-1 was highly induced on pulmonary T cells in our inflammatory model. PD-1 deficiency was associated with an increased neutrophilic AHR and high recruitment of inflammatory cells to the lungs. Consistently, PD-1 agonist treatment dampened AHR, decreased neutrophil recruitment, and modulated cytokine production in a humanized PD-1 mouse model. Mechanistically, we demonstrated at the transcriptional and protein levels that the inhibitory effect of PD-1 agonist is associated with the reprogramming of pulmonary effector T cells that showed decreased number and activation. <\/p>\n<\/section>\n

\n

Conclusion:<\/h3>\n

PD-1 agonist treatment is efficient in dampening neutrophilic AHR and lung inflammation in a preclinical humanized mouse model.<\/p>\n<\/section>","paragraphe_en":"","documents":null},"yoast_head":"\nHuman PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/human-pd-1-agonist-treatment-alleviates-neutrophilic-asthma-by-reprogramming-t-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/human-pd-1-agonist-treatment-alleviates-neutrophilic-asthma-by-reprogramming-t-cells\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/human-pd-1-agonist-treatment-alleviates-neutrophilic-asthma-by-reprogramming-t-cells\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/human-pd-1-agonist-treatment-alleviates-neutrophilic-asthma-by-reprogramming-t-cells\\\/\",\"name\":\"Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells - 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