{"id":80395,"date":"2025-02-20T12:26:25","date_gmt":"2025-02-20T12:26:25","guid":{"rendered":"https:\/\/cri1149.fr\/publication\/specific-requirement-of-the-p84-p110%ce%b3-complex-of-pi3k%ce%b3-for-antibody%e2%80%90activated-inducible-cross%e2%80%90presentation-in-murine-type-2-dcs\/"},"modified":"2025-02-20T12:26:25","modified_gmt":"2025-02-20T12:26:25","slug":"specific-requirement-of-the-p84-p110%ce%b3-complex-of-pi3k%ce%b3-for-antibody%e2%80%90activated-inducible-cross%e2%80%90presentation-in-murine-type-2-dcs","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/specific-requirement-of-the-p84-p110%ce%b3-complex-of-pi3k%ce%b3-for-antibody%e2%80%90activated-inducible-cross%e2%80%90presentation-in-murine-type-2-dcs\/","title":{"rendered":"Specific Requirement of the p84\/p110\u03b3 Complex of PI3K\u03b3 for Antibody\u2010Activated, Inducible Cross\u2010Presentation in Murine Type 2 DCs"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-80395","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Adv Sci (Weinh).","date_de_publication":"20241009","numero_doi":"10.1002\/advs.202401179","equipe":[390],"auteurs-liste":[{"texte_libre":false,"auteur-lien":16349,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Aim\u00e9 C\u00e9zaire Adiko"},{"texte_libre":false,"auteur-lien":16166,"auteur-text":""},{"texte_libre":false,"auteur-lien":16172,"auteur-text":""},{"texte_libre":false,"auteur-lien":13038,"auteur-text":""},{"texte_libre":false,"auteur-lien":13071,"auteur-text":""},{"texte_libre":false,"auteur-lien":13121,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Cosmin Saveanu"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Muriel Laffargue"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Matthias P Wymann"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marc Dalod"},{"texte_libre":false,"auteur-lien":13178,"auteur-text":""},{"texte_libre":false,"auteur-lien":13153,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11600261\/"}],"paragraphe":"

Abstract<\/h2>\n

Cross\u2010presentation by MHCI is optimally efficient in type 1 dendritic cells (DC) due to their high capacity for antigen processing. However, through specific pathways, other DCs, such as type 2 DCs and inflammatory DCs (iDCs) can also cross\u2010present antigens. Fc\u03b3R\u2010mediated uptake by type 2 DC and iDC subsets mediates antibody\u2010dependent cross\u2010presentation and activation of CD8+<\/sup> T cell responses. Here, an important role for the p84 regulatory subunit of PI3K\u03b3 in mediating efficient cross\u2010presentation of exogenous antigens in otherwise inefficient cross\u2010presenting cells, such as type 2 DCs and GM\u2010CSF\u2010derived iDCs is identified. Fc\u03b3R\u2010mediated cross\u2010presentation is shown in type 2 and iDCs depend on the enzymatic activity of the p84\/p110\u03b3 complex of PI3K\u03b3, which controls the activity of the NADPH oxidase NOX2 and ROS production in murine spleen type 2 DCs and GM\u2010CSF\u2010derived iDCs. In contrast, p84\/p110\u03b3 is largely dispensable for cross\u2010presentation by type 1 DCs. These findings suggest that PI3K\u03b3\u2010targeted therapies, currently considered for oncological practice, may interfere with the ability of type 2 DCs and iDCs to cross\u2010present antigens contained in immune complexes. <\/p>","paragraphe_en":"","documents":null},"yoast_head":"\nSpecific Requirement of the p84\/p110\u03b3 Complex of PI3K\u03b3 for Antibody\u2010Activated, Inducible Cross\u2010Presentation in Murine Type 2 DCs - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/specific-requirement-of-the-p84-p110\u03b3-complex-of-pi3k\u03b3-for-antibody\u2010activated-inducible-cross\u2010presentation-in-murine-type-2-dcs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Specific Requirement of the p84\/p110\u03b3 Complex of PI3K\u03b3 for Antibody\u2010Activated, Inducible Cross\u2010Presentation in Murine Type 2 DCs - 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