{"id":64248,"date":"2023-01-26T18:07:13","date_gmt":"2023-01-26T17:07:13","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=64248"},"modified":"2025-09-11T16:47:58","modified_gmt":"2025-09-11T14:47:58","slug":"prognostic-value-of-desmoplastic-stroma-in-intrahepatic-cholangiocarcinoma","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/prognostic-value-of-desmoplastic-stroma-in-intrahepatic-cholangiocarcinoma\/","title":{"rendered":"Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-64248","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Modern Pathology.","date_de_publication":"20200828","numero_doi":"","equipe":[121],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13084,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Lorraine Blaise"},{"texte_libre":false,"auteur-lien":63209,"auteur-text":""},{"texte_libre":false,"auteur-lien":13019,"auteur-text":""},{"texte_libre":false,"auteur-lien":13157,"auteur-text":""},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.nature.com\/articles\/s41379-020-00656-y"}],"paragraphe":"[:fr]<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\r\n<p style=\"text-align: justify;\">Intrahepatic cholangiocarcinomas (iCCs) are primary tumors of the liver characterized by the presence of a desmoplastic stroma. While tumor stroma may have a protective or a pejorative value depending on the type of malignant disease, the precise role of the desmoplastic stroma in iCC remains poorly understood. The aim of the present study was to evaluate the prognostic value of stromal compartment in iCC through a multiparametric morphological analysis. Forty-nine surgically resected iCCs were included. For all cases, tumor paraffin blocks of iCCs were selected for stromal morphological characterization through quantitative and qualitative approaches using immunohistochemistry and second-harmonic generation imaging. Intratumor heterogeneity was also evaluated in regards with the different stromal features. High proportionated stromal area (PSA) (defined by stromal to tumor area ratio) was inversely correlated with vascular invasion (62.5% vs 95.7%,\u00a0<i>p<\/i>\u2009=\u20090.006) and positively correlated with well-differentiated grade (60% vs 12.5%,\u00a0<i>p<\/i>\u2009=\u20090.001). Patients with high PSA had a better disease-free survival (DFS) than patients with low stromal area (60% vs 10%,\u00a0<i>p<\/i>\u2009=\u20090.077). Low activated stroma index (defined by cancer-associated fibroblasts number to stromal area ratio) was associated with a better DFS (60% vs 10%,\u00a0<i>p<\/i>\u2009=\u20090.05). High collagen reticulation index (CRI), defined as the number of collagen fiber branches within the entire length of the collagen network, was associated with a poorer overall survival (42% vs NR,\u00a0<i>p<\/i>\u2009=\u20090.026). Furthermore, we showed that CRI was also an homogeneous marker throughout the tumor. Based on morphological features, desmoplastic stroma seems to exert a protective effect in patients with iCC. Stromal collagen reticulation may provide additional clinically relevant information. In addition, these data support the potential value to evaluate CRI in biopsy specimen.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:fr]<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\r\n<p style=\"text-align: justify;\">Intrahepatic cholangiocarcinomas (iCCs) are primary tumors of the liver characterized by the presence of a desmoplastic stroma. While tumor stroma may have a protective or a pejorative value depending on the type of malignant disease, the precise role of the desmoplastic stroma in iCC remains poorly understood. The aim of the present study was to evaluate the prognostic value of stromal compartment in iCC through a multiparametric morphological analysis. Forty-nine surgically resected iCCs were included. For all cases, tumor paraffin blocks of iCCs were selected for stromal morphological characterization through quantitative and qualitative approaches using immunohistochemistry and second-harmonic generation imaging. Intratumor heterogeneity was also evaluated in regards with the different stromal features. High proportionated stromal area (PSA) (defined by stromal to tumor area ratio) was inversely correlated with vascular invasion (62.5% vs 95.7%,\u00a0<i>p<\/i>\u2009=\u20090.006) and positively correlated with well-differentiated grade (60% vs 12.5%,\u00a0<i>p<\/i>\u2009=\u20090.001). Patients with high PSA had a better disease-free survival (DFS) than patients with low stromal area (60% vs 10%,\u00a0<i>p<\/i>\u2009=\u20090.077). Low activated stroma index (defined by cancer-associated fibroblasts number to stromal area ratio) was associated with a better DFS (60% vs 10%,\u00a0<i>p<\/i>\u2009=\u20090.05). High collagen reticulation index (CRI), defined as the number of collagen fiber branches within the entire length of the collagen network, was associated with a poorer overall survival (42% vs NR,\u00a0<i>p<\/i>\u2009=\u20090.026). Furthermore, we showed that CRI was also an homogeneous marker throughout the tumor. Based on morphological features, desmoplastic stroma seems to exert a protective effect in patients with iCC. Stromal collagen reticulation may provide additional clinically relevant information. In addition, these data support the potential value to evaluate CRI in biopsy specimen.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/prognostic-value-of-desmoplastic-stroma-in-intrahepatic-cholangiocarcinoma\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/prognostic-value-of-desmoplastic-stroma-in-intrahepatic-cholangiocarcinoma\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:47:58+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/prognostic-value-of-desmoplastic-stroma-in-intrahepatic-cholangiocarcinoma\\\/\",\"url\":\"https:\\\/\\\/cri1149.fr\\\/publication\\\/prognostic-value-of-desmoplastic-stroma-in-intrahepatic-cholangiocarcinoma\\\/\",\"name\":\"Prognostic value of desmoplastic stroma in intrahepatic cholangiocarcinoma - 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