{"id":64206,"date":"2023-01-26T12:23:30","date_gmt":"2023-01-26T11:23:30","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=64206"},"modified":"2025-09-11T16:47:58","modified_gmt":"2025-09-11T14:47:58","slug":"harnessing-mesenchymal-stromal-cells-for-the-engineering-of-human-hematopoietic-niches","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/harnessing-mesenchymal-stromal-cells-for-the-engineering-of-human-hematopoietic-niches\/","title":{"rendered":"Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-64206","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Front Immunol.","date_de_publication":"20210315","numero_doi":"","equipe":[],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Alice Pievani"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Roberto Savoldelli"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Juliane Poelchen"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Elisa Mattioli"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Giorgio Anselmi"},{"texte_libre":false,"auteur-lien":16168,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Jochen Utikal"},{"texte_libre":false,"auteur-lien":16166,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Marta Serafini"},{"texte_libre":false,"auteur-lien":13178,"auteur-text":""}],"auteurs-manuel":"[:fr] [:]","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/33790904\/"}],"paragraphe":"<p>[:fr]<\/p>\r\n<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both\u00a0<i>in vitro<\/i>\u00a0and\u00a0<i>in vivo<\/i>.<\/p>\r\n<\/div>\r\n<p>[:]<\/p>","paragraphe_en":"<p>[:fr]<\/p>\r\n<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\">Tissue engineering opens multiple opportunities in regenerative medicine, drug testing, and modeling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance, and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both\u00a0<i>in vitro<\/i>\u00a0and\u00a0<i>in vivo<\/i>.<\/p>\r\n<\/div>\r\n<p>[:]<\/p>","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/harnessing-mesenchymal-stromal-cells-for-the-engineering-of-human-hematopoietic-niches\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Harnessing Mesenchymal Stromal Cells for the Engineering of Human Hematopoietic Niches - 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