{"id":63192,"date":"2022-11-09T11:34:04","date_gmt":"2022-11-09T10:34:04","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=63192"},"modified":"2025-09-11T16:47:59","modified_gmt":"2025-09-11T14:47:59","slug":"predicting-bleeding-after-liver-biopsy-using-comprehensive-clinical-and-laboratory-investigations-a-prospective-analysis-of-302-procedures","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/predicting-bleeding-after-liver-biopsy-using-comprehensive-clinical-and-laboratory-investigations-a-prospective-analysis-of-302-procedures\/","title":{"rendered":"Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-63192","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"[:fr]J Thromb Haemost.[:]","date_de_publication":"20220921","numero_doi":"","equipe":[166],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Julien Bissonnette[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Alix Riescher-Tuczkiewicz[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Elia Gigante[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Carole Bourdin[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Larbi Boudaoud[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Heithem Soliman[:]"},{"texte_libre":false,"auteur-lien":13069,"auteur-text":""},{"texte_libre":false,"auteur-lien":13148,"auteur-text":""},{"texte_libre":false,"auteur-lien":13161,"auteur-text":""},{"texte_libre":false,"auteur-lien":13166,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Emmanuelle de Raucourt[:]"},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/36128757\/"}],"paragraphe":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\" style=\"text-align: justify;\">\r\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Liver biopsy carries a small risk of bleeding complications. No validated clinical or laboratory tool helps predict liver biopsy-related bleeding.<\/p>\r\n<p><strong class=\"sub-title\">Objectives:\u00a0<\/strong>To determine whether global hemostasis tests and\/or a clinical questionnaire could identify patients at risk of liver biopsy-related bleeding.<\/p>\r\n<p><strong class=\"sub-title\">Patients\/methods:\u00a0<\/strong>Consecutive patients scheduled for liver biopsy with an overnight hospital stay were prospectively included. Before liver biopsy, routine hemostasis tests, Platelet Function Analyzer 100, thromboelastometry, thrombin generation assay, plasma clot lysis time, and a clinical questionnaire were performed. Bleeding was defined as a liver hematoma or new free fluid on a systematic ultrasound performed 24 h after liver biopsy or a decrease in hemoglobin level of 2 g\/dL or more in patients with pre-existing free fluid in the abdominal cavity.<\/p>\r\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Three hundred two patients were included: 173 underwent percutaneous and 129 transjugular liver biopsy. There were 21 bleeding episodes (7%); 20 based on ultrasonographic criteria, 1 on laboratory criteria. None of the hemostasis tests and no item of the clinical questionnaire were associated with liver biopsy-related bleeding in the overall study group. Same results were obtained in subgroup analyses focusing on patients who underwent percutaneous liver biopsy, transjugular liver biopsy, or on patients with cirrhosis. Pain 2 h after liver biopsy was more frequent in patients with liver biopsy-related bleeding (55% vs. 23% p = .002).<\/p>\r\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>An extensive hemostasis workup, including global hemostasis assays, does not improve prediction of liver biopsy-related bleeding. Pain 2 h after liver biopsy should alert the clinician to the possibility of procedure-related bleeding.<\/p>\r\n<\/div>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Keywords:\u00a0<\/strong>blood coagulation; diagnostic techniques and procedures; hemorrhage; liver cirrhosis; liver diseases.<\/p>[:]","paragraphe_en":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"eng-abstract\" class=\"abstract-content selected\" style=\"text-align: justify;\">\r\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Liver biopsy carries a small risk of bleeding complications. No validated clinical or laboratory tool helps predict liver biopsy-related bleeding.<\/p>\r\n<p><strong class=\"sub-title\">Objectives:\u00a0<\/strong>To determine whether global hemostasis tests and\/or a clinical questionnaire could identify patients at risk of liver biopsy-related bleeding.<\/p>\r\n<p><strong class=\"sub-title\">Patients\/methods:\u00a0<\/strong>Consecutive patients scheduled for liver biopsy with an overnight hospital stay were prospectively included. Before liver biopsy, routine hemostasis tests, Platelet Function Analyzer 100, thromboelastometry, thrombin generation assay, plasma clot lysis time, and a clinical questionnaire were performed. Bleeding was defined as a liver hematoma or new free fluid on a systematic ultrasound performed 24 h after liver biopsy or a decrease in hemoglobin level of 2 g\/dL or more in patients with pre-existing free fluid in the abdominal cavity.<\/p>\r\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Three hundred two patients were included: 173 underwent percutaneous and 129 transjugular liver biopsy. There were 21 bleeding episodes (7%); 20 based on ultrasonographic criteria, 1 on laboratory criteria. None of the hemostasis tests and no item of the clinical questionnaire were associated with liver biopsy-related bleeding in the overall study group. Same results were obtained in subgroup analyses focusing on patients who underwent percutaneous liver biopsy, transjugular liver biopsy, or on patients with cirrhosis. Pain 2 h after liver biopsy was more frequent in patients with liver biopsy-related bleeding (55% vs. 23% p = .002).<\/p>\r\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>An extensive hemostasis workup, including global hemostasis assays, does not improve prediction of liver biopsy-related bleeding. Pain 2 h after liver biopsy should alert the clinician to the possibility of procedure-related bleeding.<\/p>\r\n<\/div>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Keywords:\u00a0<\/strong>blood coagulation; diagnostic techniques and procedures; hemorrhage; liver cirrhosis; liver diseases.<\/p>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/predicting-bleeding-after-liver-biopsy-using-comprehensive-clinical-and-laboratory-investigations-a-prospective-analysis-of-302-procedures\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Predicting bleeding after liver biopsy using comprehensive clinical and laboratory investigations: A prospective analysis of 302 procedures - 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