{"id":57334,"date":"2022-03-16T14:14:32","date_gmt":"2022-03-16T13:14:32","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=57334"},"modified":"2025-09-11T16:47:59","modified_gmt":"2025-09-11T14:47:59","slug":"necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/","title":{"rendered":"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-57334","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Scientific Reports","date_de_publication":"20210929","numero_doi":"","equipe":[146],"auteurs-liste":[{"texte_libre":false,"auteur-lien":13077,"auteur-text":""},{"texte_libre":false,"auteur-lien":13186,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Gaspard d\u2019Assignies[:]"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Helena S. Leitao[:]"},{"texte_libre":false,"auteur-lien":13166,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Ralph Sinkus[:]"},{"texte_libre":false,"auteur-lien":13162,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.nature.com\/articles\/s41598-021-98726-x"}],"paragraphe":"[:fr]<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\r\n<p style=\"text-align: justify;\">The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56\u00a0Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fibrosis was the only determinant of the storage, loss and shear moduli. The multifrequency dispersion coefficient had the largest AUC for necro-inflammatory activity A\u2009\u2265\u20092 [0.84 (0.71\u20130.93) vs. storage modulus AUC: 0.65 (0.50\u20130.79),\u00a0<i>p<\/i>\u2009=\u20090.03], whereas the storage modulus had the largest AUC for fibrosis F\u2009\u2265\u20092 [AUC (95% confidence intervals) 0.91 (0.79\u20130.98)] and cirrhosis F4 [0.97 (0.88\u20131.00)]. The measurement of the multifrequency dispersion coefficient at three-dimensional MR elastography has the potential to grade liver necro-inflammation in patients with chronic vial hepatitis.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:fr]<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\r\n<p style=\"text-align: justify;\">The purpose of this study was to assess the diagnostic value of multifrequency MR elastography for grading necro-inflammation in the liver. Fifty participants with chronic hepatitis B or C were recruited for this institutional review board-approved study. Their liver was examined with multifrequency MR elastography. The storage, shear and loss moduli, and the damping ratio were measured at 56\u00a0Hz. The multifrequency wave dispersion coefficient of the shear modulus was calculated. The measurements were compared to reference markers of necro-inflammation and fibrosis with Spearman correlations and multiple regression analysis. Diagnostic accuracy was assessed. At multiple regression analysis, necro-inflammation was the only determinant of the multifrequency dispersion coefficient, whereas fibrosis was the only determinant of the storage, loss and shear moduli. The multifrequency dispersion coefficient had the largest AUC for necro-inflammatory activity A\u2009\u2265\u20092 [0.84 (0.71\u20130.93) vs. storage modulus AUC: 0.65 (0.50\u20130.79),\u00a0<i>p<\/i>\u2009=\u20090.03], whereas the storage modulus had the largest AUC for fibrosis F\u2009\u2265\u20092 [AUC (95% confidence intervals) 0.91 (0.79\u20130.98)] and cirrhosis F4 [0.97 (0.88\u20131.00)]. The measurement of the multifrequency dispersion coefficient at three-dimensional MR elastography has the potential to grade liver necro-inflammation in patients with chronic vial hepatitis.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-11T14:47:59+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/\",\"name\":\"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography - CRI\",\"isPartOf\":{\"@id\":\"https:\/\/cri1149.fr\/#website\"},\"datePublished\":\"2022-03-16T13:14:32+00:00\",\"dateModified\":\"2025-09-11T14:47:59+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/cri1149.fr\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\",\"item\":\"https:\/\/cri1149.fr\/publications\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/cri1149.fr\/#website\",\"url\":\"https:\/\/cri1149.fr\/\",\"name\":\"CRI - Centre de Recherche sur l'Inflammation\",\"description\":\"Centre de Recherche sur l&#039;Inflammation\",\"publisher\":{\"@id\":\"https:\/\/cri1149.fr\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/cri1149.fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/cri1149.fr\/#organization\",\"name\":\"CRI1149\",\"url\":\"https:\/\/cri1149.fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"contentUrl\":\"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg\",\"width\":215,\"height\":176,\"caption\":\"CRI1149\"},\"image\":{\"@id\":\"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/\"},\"sameAs\":[\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\",\"https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography - CRI","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/","og_locale":"en_US","og_type":"article","og_title":"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography - CRI","og_url":"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/","og_site_name":"CRI","article_publisher":"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","article_modified_time":"2025-09-11T14:47:59+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/","url":"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/","name":"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography - CRI","isPartOf":{"@id":"https:\/\/cri1149.fr\/#website"},"datePublished":"2022-03-16T13:14:32+00:00","dateModified":"2025-09-11T14:47:59+00:00","breadcrumb":{"@id":"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/cri1149.fr\/publication\/necro-inflammatory-activity-grading-in-chronic-viral-hepatitis-with-three-dimensional-multifrequency-mr-elastography\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/cri1149.fr\/en\/"},{"@type":"ListItem","position":2,"name":"Publications","item":"https:\/\/cri1149.fr\/publications\/"},{"@type":"ListItem","position":3,"name":"Necro-inflammatory activity grading in chronic viral hepatitis with three-dimensional multifrequency MR elastography"}]},{"@type":"WebSite","@id":"https:\/\/cri1149.fr\/#website","url":"https:\/\/cri1149.fr\/","name":"CRI - Centre de Recherche sur l'Inflammation","description":"Centre de Recherche sur l&#039;Inflammation","publisher":{"@id":"https:\/\/cri1149.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/cri1149.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/cri1149.fr\/#organization","name":"CRI1149","url":"https:\/\/cri1149.fr\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/","url":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","contentUrl":"https:\/\/cri1149.fr\/wp-content\/uploads\/2014\/11\/8.4.2014-logo-CRI.jpg","width":215,"height":176,"caption":"CRI1149"},"image":{"@id":"https:\/\/cri1149.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153","https:\/\/www.linkedin.com\/company\/cri-centre-de-recherche-sur-l-inflammation\/"]}]}},"_links":{"self":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication\/57334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/types\/publication"}],"acf:term":[{"embeddable":true,"taxonomy":"equipes","href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/equipes\/146"}],"wp:attachment":[{"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/media?parent=57334"}],"wp:term":[{"taxonomy":"category_publication","embeddable":true,"href":"https:\/\/cri1149.fr\/en\/wp-json\/wp\/v2\/category_publication?post=57334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}