{"id":57327,"date":"2022-03-16T12:17:01","date_gmt":"2022-03-16T11:17:01","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&#038;p=57327"},"modified":"2025-09-11T16:47:59","modified_gmt":"2025-09-11T14:47:59","slug":"quantification-of-hepatic-steatosis-with-ultrasound-promising-role-of-attenuation-imaging-coefficient-in-a-biopsy-proven-cohort","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/quantification-of-hepatic-steatosis-with-ultrasound-promising-role-of-attenuation-imaging-coefficient-in-a-biopsy-proven-cohort\/","title":{"rendered":"Quantification of hepatic steatosis with ultrasound: promising role of attenuation imaging coefficient in a biopsy-proven cohort"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-57327","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"[:fr]Eur Radiol.[:]","date_de_publication":"20200401","numero_doi":"","equipe":[146],"auteurs-liste":[{"texte_libre":false,"auteur-lien":14728,"auteur-text":""},{"texte_libre":false,"auteur-lien":13148,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"[:fr]Edouard Reizine[:]"},{"texte_libre":false,"auteur-lien":13244,"auteur-text":""},{"texte_libre":false,"auteur-lien":13047,"auteur-text":""},{"texte_libre":false,"auteur-lien":13135,"auteur-text":""},{"texte_libre":false,"auteur-lien":13077,"auteur-text":""},{"texte_libre":false,"auteur-lien":13162,"auteur-text":""},{"texte_libre":false,"auteur-lien":13166,"auteur-text":""}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/pubmed.ncbi.nlm.nih.gov\/31822978\/"}],"paragraphe":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Objectives:\u00a0<\/strong>To prospectively assess the role of the US attenuation imaging coefficient (AC) for the diagnosis and quantification of hepatic steatosis.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Methods:\u00a0<\/strong>One hundred and one patients underwent liver biopsy and US-AC measurement on the same day. Liver steatosis was graded according to biopsy as absent (S0 &lt; 5%), mild (S1 5-33%), moderate (S2 33-66%), or severe (S3 &gt; 66%); liver fibrosis was graded from F0 to F4. The correlation between AC and steatosis on pathology (%) was calculated using the Pearson correlation coefficient. The Student t or Mann-Whitney U test was used to compare continuous variables and ROC curve analysis was used to assess diagnostic performance of AC in diagnosing steatosis.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results:\u00a0<\/strong>Overall, 43 (42%), 35 (35%), 12 (12%), and 11 (11%) patients were classified as S0, S1, S2, and S3, respectively. The AC was positively correlated with steatosis as a continuous variable (%) on pathology (r = 0.58, p &lt; 0.01). Patients with steatosis of any grade had a higher AC than those without steatosis (mean 0.77 \u00b1 0.13 vs. 0.63 \u00b1 0.09 dB\/cm\/MHz, respectively; p &lt; 0.01, AUROC = 0.805). Patients with S2-S3 had a higher AC than patients with S0-1 (0.85 \u00b1 0.11 vs. 0.67 \u00b1 0.11 dB\/cm\/MHz, respectively; p &lt; 0.01, AUROC = 0.892). AC &gt; 0.69 dB\/cm\/MHz had a sensitivity and specificity of 76% and 86%, respectively, for diagnosing any grade of steatosis (S1-S3), and AC &gt; 0.72 dB\/cm\/MHz had a sensitivity and specificity of 96% and 74%, respectively, for diagnosing S2-S3. The presence of advanced fibrosis (F3-F4) did not affect the calculated AC.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>The attenuation imaging coefficient is a promising quantitative technique for the non-invasive diagnosis and quantification of hepatic steatosis.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Key points:\u00a0<\/strong>\u2022 Measurement of the attenuation coefficient is achieved with a very high rate of technical success. \u2022 We found a significant positive correlation between the attenuation coefficient and the grade of steatosis on pathology. \u2022 The attenuation imaging coefficient is a promising quantitative technique for the noninvasive diagnosis and quantification of hepatic steatosis.<\/p>\r\n<\/div>[:]","paragraphe_en":"[:fr]<h2 class=\"title\" style=\"text-align: justify;\">Abstract<\/h2>\r\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Objectives:\u00a0<\/strong>To prospectively assess the role of the US attenuation imaging coefficient (AC) for the diagnosis and quantification of hepatic steatosis.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Methods:\u00a0<\/strong>One hundred and one patients underwent liver biopsy and US-AC measurement on the same day. Liver steatosis was graded according to biopsy as absent (S0 &lt; 5%), mild (S1 5-33%), moderate (S2 33-66%), or severe (S3 &gt; 66%); liver fibrosis was graded from F0 to F4. The correlation between AC and steatosis on pathology (%) was calculated using the Pearson correlation coefficient. The Student t or Mann-Whitney U test was used to compare continuous variables and ROC curve analysis was used to assess diagnostic performance of AC in diagnosing steatosis.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Results:\u00a0<\/strong>Overall, 43 (42%), 35 (35%), 12 (12%), and 11 (11%) patients were classified as S0, S1, S2, and S3, respectively. The AC was positively correlated with steatosis as a continuous variable (%) on pathology (r = 0.58, p &lt; 0.01). Patients with steatosis of any grade had a higher AC than those without steatosis (mean 0.77 \u00b1 0.13 vs. 0.63 \u00b1 0.09 dB\/cm\/MHz, respectively; p &lt; 0.01, AUROC = 0.805). Patients with S2-S3 had a higher AC than patients with S0-1 (0.85 \u00b1 0.11 vs. 0.67 \u00b1 0.11 dB\/cm\/MHz, respectively; p &lt; 0.01, AUROC = 0.892). AC &gt; 0.69 dB\/cm\/MHz had a sensitivity and specificity of 76% and 86%, respectively, for diagnosing any grade of steatosis (S1-S3), and AC &gt; 0.72 dB\/cm\/MHz had a sensitivity and specificity of 96% and 74%, respectively, for diagnosing S2-S3. The presence of advanced fibrosis (F3-F4) did not affect the calculated AC.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>The attenuation imaging coefficient is a promising quantitative technique for the non-invasive diagnosis and quantification of hepatic steatosis.<\/p>\r\n<p style=\"text-align: justify;\"><strong class=\"sub-title\">Key points:\u00a0<\/strong>\u2022 Measurement of the attenuation coefficient is achieved with a very high rate of technical success. \u2022 We found a significant positive correlation between the attenuation coefficient and the grade of steatosis on pathology. \u2022 The attenuation imaging coefficient is a promising quantitative technique for the noninvasive diagnosis and quantification of hepatic steatosis.<\/p>\r\n<\/div>[:]","documents":null},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Quantification of hepatic steatosis with ultrasound: promising role of attenuation imaging coefficient in a biopsy-proven cohort - 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