{"id":57222,"date":"2022-03-15T11:38:20","date_gmt":"2022-03-15T10:38:20","guid":{"rendered":"https:\/\/cri1149.fr\/?post_type=publications&p=57222"},"modified":"2025-12-09T15:02:54","modified_gmt":"2025-12-09T14:02:54","slug":"targeting-the-endo-lysosomal-autophagy-pathway-to-treat-inflammatory-bowel-diseases","status":"publish","type":"publication","link":"https:\/\/cri1149.fr\/en\/publication\/targeting-the-endo-lysosomal-autophagy-pathway-to-treat-inflammatory-bowel-diseases\/","title":{"rendered":"Targeting the endo-lysosomal autophagy pathway to treat inflammatory bowel diseases"},"content":{"rendered":"","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":true,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false},"category_publication":[],"class_list":["post-57222","publication","type-publication","status-publish","hentry"],"acf":{"numero_de_publication":"Journal of Autoimmunity","date_de_publication":"20220314","numero_doi":"","equipe":[143],"auteurs-liste":[{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sruthi VijayaRetnakumar"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Ramasatyaveni Geesala"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Alexis Bretin"},{"texte_libre":false,"auteur-lien":13198,"auteur-text":""},{"texte_libre":false,"auteur-lien":13131,"auteur-text":""},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Thorsten Maretzky"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Hang Thi Thu Nguyen"},{"texte_libre":true,"auteur-lien":null,"auteur-text":"Sylviane Muller"}],"auteurs-manuel":"","liens_externes":null,"liens":[{"lien":"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896841122000221?dgcid=coauthor"}],"paragraphe":"

Abstract<\/h2>\r\n
\r\n

Inflammatory bowel disease<\/a>\u00a0(IBD) is a serious public health problem in Western society with a continuing increase in incidence worldwide. Safe, targeted medicines for IBD are not yet available. Autophagy, a vital process implicated in normal cell\u00a0homeostasis<\/a>, provides a potential point of entry for the treatment of IBDs, as several autophagy-related genes are associated with IBD risk. We conducted a series of experiments in three distinct mouse models of\u00a0colitis<\/a>\u00a0to test the effectiveness of therapeutic P140, a\u00a0phosphopeptide<\/a>\u00a0that corrects autophagy dysfunctions in other autoimmune and\u00a0inflammatory diseases<\/a>. Colitis was experimentally induced in mice by administering\u00a0dextran sodium sulfate<\/a>\u00a0and 2,4,6\u00a0trinitrobenzene sulfonic acid<\/a>.\u00a0Transgenic mice<\/a>\u00a0lacking both\u00a0il-10<\/em>\u00a0and\u00a0iRhom2<\/em>\u00a0\u2212\u00a0involved in\u00a0tumor necrosis factor \u03b1<\/a> secretion\u00a0\u2212\u00a0were also used. In the three models investigated, P140 treatment attenuated the clinical and histological severity of colitis. Post-treatment, altered expression of several macroautophagy and chaperone-mediated autophagy markers, and of pro-inflammatory mediators was corrected. Our results demonstrate that therapeutic intervention with an autophagy modulator improves colitis in animal models. These findings highlight the potential of therapeutic peptide P140 for use in the treatment of IBD.<\/p>\r\n\r\n<\/div>","paragraphe_en":"[:fr]\r\n

Abstract<\/h2>\r\n
\r\n

Inflammatory bowel disease<\/a>\u00a0(IBD) is a serious public health problem in Western society with a continuing increase in incidence worldwide. Safe, targeted medicines for IBD are not yet available. Autophagy, a vital process implicated in normal cell\u00a0homeostasis<\/a>, provides a potential point of entry for the treatment of IBDs, as several autophagy-related genes are associated with IBD risk. We conducted a series of experiments in three distinct mouse models of\u00a0colitis<\/a>\u00a0to test the effectiveness of therapeutic P140, a\u00a0phosphopeptide<\/a>\u00a0that corrects autophagy dysfunctions in other autoimmune and\u00a0inflammatory diseases<\/a>. Colitis was experimentally induced in mice by administering\u00a0dextran sodium sulfate<\/a>\u00a0and 2,4,6\u00a0trinitrobenzene sulfonic acid<\/a>.\u00a0Transgenic mice<\/a>\u00a0lacking both\u00a0il-10<\/em>\u00a0and\u00a0iRhom2<\/em>\u00a0\u2212\u00a0involved in\u00a0tumor necrosis factor \u03b1<\/a>\u00a0secretion\u00a0\u2212\u00a0were also used. In the three models investigated, P140 treatment attenuated the clinical and histological severity of colitis. Post-treatment, altered expression of several macroautophagy and chaperone-mediated autophagy markers, and of pro-inflammatory mediators was corrected. Our results demonstrate that therapeutic intervention with an autophagy modulator improves colitis in animal models. These findings highlight the potential of therapeutic peptide P140 for use in the treatment of IBD.<\/p>\r\n\r\n<\/div>\r\n[:]","documents":null},"yoast_head":"\nTargeting the endo-lysosomal autophagy pathway to treat inflammatory bowel diseases - CRI<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cri1149.fr\/publication\/targeting-the-endo-lysosomal-autophagy-pathway-to-treat-inflammatory-bowel-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeting the endo-lysosomal autophagy pathway to treat inflammatory bowel diseases - CRI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cri1149.fr\/publication\/targeting-the-endo-lysosomal-autophagy-pathway-to-treat-inflammatory-bowel-diseases\/\" \/>\n<meta property=\"og:site_name\" content=\"CRI\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CRI-Centre-de-recherche-sur-linflammation-100116118884153\" \/>\n<meta property=\"article:modified_time\" content=\"2025-12-09T14:02:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cri1149.fr\/publication\/targeting-the-endo-lysosomal-autophagy-pathway-to-treat-inflammatory-bowel-diseases\/\",\"url\":\"https:\/\/cri1149.fr\/publication\/targeting-the-endo-lysosomal-autophagy-pathway-to-treat-inflammatory-bowel-diseases\/\",\"name\":\"Targeting the endo-lysosomal autophagy pathway to treat inflammatory bowel diseases - 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